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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of
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Soliciting Materials Pursuant to Rule 14a-11(c) or Rule 14a-12
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AVANT IMMUNOTHERAPEUTICS, INC.
Celldex Therapeutics, Inc.

(Name of CompanyRegistrant as Specified inIn Its Charter)

 

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AVANT IMMUNOTHERAPEUTICS,CELLDEX THERAPEUTICS, INC.
119 FOURTH AVENUEPerryville III Building
NEEDHAM, MA 02494

53 Frontage Road, Suite 220
Hampton, NJ 08827
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To be held on September 25, 2008June 15, 2017

To the Stockholders of
AVANT Immunotherapeutics,Celldex Therapeutics, Inc.

        NOTICE IS HEREBY GIVENthat the Annual Meeting of Stockholders of AVANT Immunotherapeutics,Celldex Therapeutics, Inc. (the “Company”"Company" or "we" or "us") will be held at the offices of Lowenstein Sandler PC, 1251 Avenue of the Americas, 18th Floor,Olde Mill Inn, 225 Route 202, Basking Ridge, New York, NY 10020Jersey 07920, on September 25, 2008June 15, 2017 beginning at 9:00 a.m. local time. At the meeting, stockholders will act on the following matters:matters to:

        Only stockholders of record at the close of business on August 15, 2008April 20, 2017 are entitled to receive notice of and to vote at the Annual Meeting or any postponement or adjournment thereof.

        Your vote is important. Whether you plan to attend the meeting or not, you may vote your shares by marking, signing, dating and mailing the enclosed proxy card in the envelope provided. If you attend the meeting and prefer to vote in person, you may do so even if you have already voted your shares. You may revoke your proxy in the manner described in the proxy statement at any time before it has been voted at the meeting.

 By Order of the Board of Directors

 

 

Avery W. Catlin

Chief Financial Officer and
Secretary
August __, 2008 
Needham, MA 

May 3, 2017




AVANT IMMUNOTHERAPEUTICS, INC.
119 FOURTH AVENUE
NEEDHAM, MA 02494Hampton, NJ


CELLDEX THERAPEUTICS, INC.
Perryville III Building
53 Frontage Road, Suite 220
Hampton, NJ 08827



PROXY STATEMENT




        This proxy statement contains information related to the Annual Meeting of Stockholders to be held on September 25, 2008June 15, 2017 at 9:00 a.m. local time, at the offices of Lowenstein Sandler PC, 1251 Avenue of the Americas, 18th Floor,Olde Mill Inn, 225 Route 202, Basking Ridge, New York, NY 10020,Jersey 07920, or at such other time and place to which the Annual Meeting may be adjourned or postponed. The enclosed proxy is solicited by the Board of Directors of AVANT Immunotherapeutics,Celldex Therapeutics, Inc. The proxy materials relating to the Annual Meeting are being mailed to stockholders entitled to vote at the meeting on or about August __, 2008.May 3, 2017.

Important Notice of Availability of Proxy Materials for the Annual Meeting of Stockholders to be held on June 15, 2017.

Our proxy materials, including our Proxy Statement for the 2017 Annual Meeting, 2016 Annual Report to Stockholders (which contains our Annual Report on Form 10-K) and proxy card, are available on the Internet at www.proxyvote.com.


ABOUT THE MEETING

Why are we calling this Annual Meeting?

        We are calling the Annual Meeting to seek the approval of our stockholders to:

  • To elect seveneight directors to serve until the next Annual Meeting of Stockholders and until their respective successors shall have been duly elected and qualified;

  • To ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2008;2017;

  • Approveapprove, in accordance with the applicable rules of the NASDAQ Stock Market, the issuance of shares of our common stock in connection with Milestone Payments that may become payable in the future to former securityholders of Kolltan Pharmaceuticals, Inc. under the terms of the Merger Agreement we entered into in November 2016;

    approve an amendment to our Certificate2008 Stock Option and Incentive Plan to increase the shares reserved for issuance thereunder by 5,650,000 shares to 20,000,000 shares;

    approve an amendment to our 2004 Employee Stock Purchase Plan to increase the shares reserved for issuance thereunder by 200,000 shares to 400,000 shares;

    approve, on an advisory basis, the compensation of Incorporation to change our name to "Celldex Therapeutics, Inc.";the Company's Named Executive Officers as disclosed in this proxy statement;

    indicate, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's Named Executive Officers; and

  • Any
    address any other matters that may properly come before the meeting.

What are the Board's recommendations?

        Our Board of Directors believesrecommends that you vote:

    FOR the election of each of the eight director nominees identified herein,nominees;

    FOR the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2008, and2017;

    FOR the approval, in accordance with the applicable rules of the NASDAQ Stock Market, of the issuance of shares of our common stock in connection with Milestone Payments that may become payable in the future to former securityholders of Kolltan Pharmaceuticals, Inc. under the terms of the Merger Agreement we entered into in November 2016;

    FOR the approval of an amendment to our Certificate2008 Stock Option and Incentive Plan to increase the shares reserved for issuance thereunder by 5,650,000 shares to 20,000,000 shares;

    FOR the approval of Incorporationan amendment to change our name2004 Employee Stock Purchase Plan to "Celldex Therapeutics, Inc." are advisable and inincrease the best interestsshares reserved for issuance thereunder by 200,000 shares to 400,000 shares;

    FOR an advisory vote on the compensation of the CompanyNamed Executive Officers as described in this proxy statement; and its stockholders and recommends that you

    FOR an advisory vote FOR these proposals.


    on our executive compensation to be held on an annual frequency.

Who is entitled to vote at the meeting?

        Only stockholders of record at the close of business on the record date, August 15, 2008,April 20, 2017, are entitled to receive notice of the Annual Meeting and to vote the shares of common stock that they held on that date at the meeting, or any postponement or adjournment of the meeting. Holders of our common stock are entitled to one vote per share on each matter to be voted upon.

As of the record date, we had [                ] outstanding shares of common stock.

Who can attend the meeting?

        All stockholders as of the record date, or their duly appointed proxies, may attend the Annual Meeting. Please note that if you hold your shares in “street name”"street name" (that is, through a broker or other nominee), you will need to bring a copy of your proxy card delivered to you by your broker or a legal proxy given to you by your broker and check in at the registration desk at the meeting.

     In accordance with our For security procedures,reasons, you must comply with our pre-registration requirements, you must present a form of government-issuedgovernment issued photograph identification to security on the day of the Annual Meeting, and you must arrive at least thirty minutes prior to the meeting in order to attend the Annual Meeting. If you are a shareholderstockholder of record and plan to attend the Annual Meeting, please contact [__________]Kathy Reamer by email at [_________]kreamer@celldex.com or by phone at [_________]908-200-7500 ext. 7508 to register to attend the Annual Meeting. If you hold shares through an intermediary, such as a bank or broker, and you plan to attend, you must send a written request to attend either by regular mail fax or email, along with proof of share ownership, such as a bank or brokerage firm account statement, confirming ownership to: [________].Celldex Therapeutics, Inc., Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827, Attn: Kathy Reamer or kreamer@celldex.com. Attendance at the Annual Meeting will be limited to persons who pre-registered on or before September 22, 2008,June 8, 2017, who present a form of government-issued photograph identification on the day of the Annual Meeting and who arrive by 8:30 ama.m. local time.

What constitutes a quorum?

        The presence at the Annual Meeting, in person or by proxy, of the holders of a majority of our common stock outstanding on the record date will constitute a quorum for our meeting. Signed proxies


received but not voted and broker non-votes will be included in the calculation of the number of shares considered to be present at the meeting.

How do I vote?

        You can vote on matters that come before the Annual Meeting by completing, dating and signing the enclosed proxy card and returning it in the enclosed postage-paid envelope.

        Your shares will be voted as you indicate on your proxy card. If you vote the enclosed proxy but you do not indicate your voting preferences, and with respect to any other matter that properly comes before the meeting, the individuals named on the proxy card will vote your shares FOR the matters submitted at the meeting, or if no recommendation is given, in their own discretion.

-4-        If you are a stockholder of record, to submit your proxy by telephone or via the Internet, follow the instructions on the proxy card. If you hold your shares in street name, you may vote by telephone or via the Internet as instructed by your broker, bank or other nominee.


        If you attend the Annual Meeting and prefer to vote in person, you may do so even if you have already voted your shares by proxy.

What if I vote and then change my mind?

        You may revoke your proxy at any time before it is exercised by:

  • filing with the Secretary of the Company a notice of revocation;

  • sending in another duly executed proxy bearing a later date; or

  • attending the meeting and casting your vote in person.

        Your latest vote will be the vote that is counted.

What is the difference between holding shares as a stockholder of record and as a beneficial owner?

        Many of our stockholders hold their shares through a stockbroker, bank or other nominee rather than directly in their own name. As summarized below, there are some distinctions between shares held of record and those owned beneficially.

Stockholder of Record

        If your shares are registered directly in your name with our transfer agent, Computershare Trust Company, N.A., you are considered, with respect to those shares, the stockholder of record. As the stockholder of record, you have the right to grant your voting proxy directly to us or to vote in person at the Annual Meeting.

Beneficial Owner

        If your shares are held in a stock brokerage account or by a bank or other nominee, you are considered the beneficial owner of shares held in street name, and these proxy materials are being forwarded to you by your broker, bank or nominee which is considered, with respect to those shares, the stockholder of record. As the beneficial owner, you have the right to direct your broker as to how to vote and are also invited to attend the Annual Meeting. However, because you are not the stockholder of record, you may not vote these shares in person at the Annual Meeting unless you obtain a signed proxy from the record holder giving you the right to vote the shares. If you do not vote your shares or otherwise provide the stockholder of record with voting instructions, your shares may constitute broker non-votes. The effect of broker non-votes is more specifically described in “What"What vote is required to approve each proposal?" below.


What are "broker non-votes"?

        Broker non-votes occur when nominees, such as banks and brokers holding shares on behalf of beneficial owners, do not receive voting instructions from the beneficial holders at least ten days before the meeting. If that happens, the nominees may vote those shares only on matters deemed "routine", such as the ratification of auditors. Nominees cannot vote on non-routine matters unless they receive voting instructions from beneficial holders, resulting in so-called "broker non-votes."

        The election of directors (Proposal No. 1), the approval, in accordance with the applicable rules of the NASDAQ Stock Market, of the issuance of shares of our common stock in connection with Milestone Payments that may become payable in the future to former securityholders of Kolltan Pharmaceuticals, Inc. under the terms of the Merger Agreement we entered into in November 2016 (Proposal No. 3), the approval of an amendment to our 2008 Stock Option and Incentive Plan to increase the shares reserved for issuance thereunder by 5,650,000 shares to 20,000,000 shares (Proposal No. 4), the approval of an amendment to our 2004 Employee Stock Purchase Plan to increase the shares reserved for issuance thereunder by 200,000 shares to 400,000 shares (Proposal No. 5), the advisory vote on the compensation of our Named Executive Officers (Proposal No. 6) and the advisory vote on the frequency of stockholder advisory votes on the compensation of our Named Executive Officers (Proposal No. 7) are not considered to be "routine" matters, and brokers are not permitted to vote on those matters if the broker has not received instructions from the beneficial owner. Accordingly, it is particularly important that beneficial owners instruct their brokers how they wish to vote their shares. The ratification of our independent registered public accounting firm (Proposal No. 2) is considered to be a "routine" matter, and hence your brokerage firm will be able to vote on Proposal No. 2 even if it does not receive instructions from you, so long as it holds your shares in its name.

What vote is required to approve each proposal?

        Holders of a majority of the outstanding shares entitled to vote must be present, in person or by proxy, at the Annual Meeting in order to have the required quorum for the transaction of business. Pursuant to Delaware corporate law, abstentions and broker non-votes will be counted for the purpose of determining whether a quorum is present. Abstentions and broker non-votes are not counted for the purpose of determining the number of votes cast and will therefore not have any effect with respect to any of the proposals.

-5-        Assuming that a quorum is present, the following votes will be required:


    With respect to the first proposal (electionelection of directors)directors (Proposal No. 1), directorseach nominee presented in Proposal 1 must be elected by a majority of the votes cast in person or by proxy at the Annual Meeting. Nominees are elected by a plurality ofmajority vote for non-contested director elections. Because the votes present in person or represented by proxy and entitled to vote, and the director nominees who receive the greatest number of votes atnominees properly nominated for the Annual Meeting (up tois the totalsame as the number of directors to be elected)elected, the election of directors at this Annual Meeting is non-contested. If the number of votes "For" a nominee exceeds the number of votes "Withheld" (among votes properly cast in person or by proxy), then the nominee will be elected. As a result, abstentions and “broker non-votes” (see below), if any, will not affect the outcome of the vote on this proposal.



    With respect to the third proposal (approvalratification of an amendment tothe appointment of PricewaterhouseCoopers LLP as our Certificate of Incorporation)independent registered public accounting firm (Proposal No. 2), approval will require the affirmative vote of a majority of our outstanding shares of common stock is required to approve the proposal. As a result, abstentions will have the same practical effect as a negative vote on this proposal, and “broker non-votes” (see below), if any, will not affect the outcome of the vote on this proposal.

         With respect to the other proposals and approval of any other matter that may properly come before the Annual Meeting, the affirmative voteholders of a majority of the total votes cast on these proposals, in person or by proxy is requiredat the Annual Meeting.

    With respect to approve these proposals. Asthe approval, in accordance with the applicable rules of the NASDAQ Stock Market, of the issuance of shares of our common stock in connection with Milestone Payments that may become payable in the future to former securityholders of Kolltan Pharmaceuticals, Inc. under the terms of the Merger Agreement we entered into in November

      2016 (Proposal No. 3), approval will require the affirmative vote of the holders of a result, abstentionsmajority of the total votes cast in person or by proxy at the Annual Meeting.

    With respect to the approval of an amendment to our 2008 Stock Option and Incentive Plan to increase the shares reserved for issuance thereunder by 5,650,000 shares to 20,000,000 shares (Proposal No. 4), approval will haverequire the same practical effect asaffirmative vote of the holders of a negativemajority of the total votes cast in person or by proxy at the Annual Meeting.

    With respect to the approval of an amendment to our 2004 Employee Stock Purchase Plan to increase the shares reserved for issuance thereunder by 200,000 shares to 400,000 shares (Proposal No. 5), approval will require the affirmative vote of the holders of a majority of the total votes cast in person or by proxy at the Annual Meeting.

    With respect to the advisory vote on these proposals, and “broker non-votes” (see below)the compensation of our Named Executive Officers as disclosed in this proxy statement (Proposal No. 6), if any,approval will not affectrequire the outcomeaffirmative vote of the holders of a majority of the total votes cast in person or by proxy at the Annual Meeting.

    With respect to the advisory vote on these proposals.

    the frequency of stockholder advisory votes on the compensation of our Named Executive Officers (Proposal No. 7), the frequency receiving the highest number of votes cast in person or by proxy at the Annual Meeting will be considered the frequency preferred by our stockholders.

        Holders of the common stock will not have any dissenters’dissenters' rights of appraisal in connection with any of the matters to be voted on at the meeting.

What are "broker non-votes"?Where can I find more information about the terms of the Kolltan Acquisition?

        Broker non-votes occur when nominees, such as banksWe are including in this Proxy Statement a summary of the material terms of the Kolltan Acquisition because we believe an understanding of the Kolltan Acquisition is necessary in order to make an informed voting decision with respect to the potential issuance of our securities in connection with Milestone Payments that may become due in the future under the terms of the Merger Agreement we entered into in November 2016. We are not seeking stockholder approval or ratification of the Kolltan Acquisition because the transaction has been consummated and brokers holding sharesthe issuance of the consideration paid at closing did not require stockholder approval. There are no "dissenters" or "appraisal" rights available to our stockholders in connection with Proposal 3. Your vote will determine whether we will have the ability to elect to pay any Milestone Payments that are earned in the future in common stock (or will instead be required to make all Milestone Payments in cash). A summary of the terms of the Kolltan Acquisition is set forth below:

    We consummated the Kolltan Acquisition on behalfNovember 29, 2016 pursuant to an agreement and plan of beneficial owners, do not receive voting instructions frommerger, dated November 1, 2016, (the "Merger Agreement") by and among us, Kolltan, two wholly-owned subsidiaries of ours formed for the beneficial holders at least ten days beforepurpose of the meeting. If that happens, the nominees may vote those shares only on matters deemed “routine” by the New York Stock Exchange, suchacquisition, and Shareholder Representative Services LLC, solely in its capacity as the electionStockholders Representative.

    The consideration paid at closing to the former securityholders of directorsKolltan consisted of 18,257,996 shares of our common stock (the "Closing Merger Consideration"). In addition, we agreed to issue an aggregate of 437,901 shares of our common stock to certain officers of Kolltan in lieu of cash severance obligations.

    In addition, we will be required to pay to the former securityholders of Kolltan, if earned after the closing, Milestone Payments in an amount of up to $172.5 million in the aggregate, in the event of the successful completion of certain specified milestone events. The Merger Agreement provides that Milestone Payments may be made in cash or in stock, at our option; provided, however we are required to maintain a certain percentage of the overall consideration paid in

      shares of our common stock to satisfy certain tax requirements under the Merger Agreement and we will pay cash to any non-accredited former securityholders of Kolltan. For a description of the milestone events, the respective Milestone Payment payable upon achievement thereof, and the adoptionmanner in which the Milestone Payments are to be paid, see the chart and related discussion appearing in Proposal 3 under the caption"Mechanics of Milestone Payments."

        To better understand Proposal 3 and the Kolltan Acquisition, you should carefully read this entire document and the other documents to which we refer. For a more detailed discussion of the increaseKolltan Acquisition, please see the section entitled"Proposal 3—Approval, In Accordance With The Applicable Rules Of The NASDAQ Stock Market, Of The Issuance Of Shares Of Our Common Stock In Connection With Milestone Payments That May Become Payable In The Future To Former Securityholders Of Kolltan Pharmaceuticals, Inc."

Why is stockholder approval necessary in authorizedorder to pay Milestone Payments in stock?

        Our common stock is listed on the NASDAQ Global Market, and we are subject to the NASDAQ listing standards set forth in its Marketplace Rules. Although we were not required to obtain stockholder approval in connection with the issuance of the Closing Merger Consideration because the shares of our common stock issued at Closing constituted less than 20% of our outstanding shares, we are required under Marketplace Rule 5635(a) to seek stockholder approval for the issuance of shares of common stock. Nominees cannot vote on non-routine matters unless they receive voting instructions from beneficial holders, resultingstock in so-called “broker non-votes.” The effectconnection with the Milestone Payments as further described below.

        NASDAQ Marketplace Rule 5635(a) requires stockholder approval prior to the issuance of broker non-votes on eachsecurities in connection with the acquisition of the proposalsstock or assets of another company, including pursuant to an "earn-out" or similar provision, where due to the present or potential issuance of common stock (or securities convertible into or exercisable for common stock), other than a public offering for cash, the common stock to be issued (a) constitutes voting power in excess of 20% of the outstanding voting power prior to the issuance or (b) is or will be in excess of 20% of the outstanding common stock prior to the issuance. The Closing Merger Consideration that we have already issued to former Kolltan securityholders (including shares deposited for their benefit into escrow) did not constitute more than 20% of our total shares of common stock outstanding, so we were not required to obtain stockholder approval for the issuance of these shares. The Closing Merger Consideration constituted an amount of our common stock equivalent to approximately 18.5% of our outstanding common stock as of the November 1, 2016 execution date of the Merger Agreement. The issuance of additional shares of common stock to former Kolltan securityholders in connection with the Milestone Payments would be aggregated with the shares we issued as Closing Merger Consideration for purposes of NASDAQ Marketplace Rule 5635(a). Accordingly, issuing additional shares of common stock as Milestone Payments to the former Kolltan securityholders may result in the aggregate number of shares issued by us in connection with the Kolltan Acquisition exceeding 20% of our total shares outstanding prior to the Kolltan Acquisition. Therefore, we are requesting stockholder approval for Proposal 3 under this NASDAQ listing standard to ensure that we have stockholder approval to issue shares of common stock as Milestone Payments to the extent that any such shares issued, when aggregated with shares previously issued in connection with the Kolltan Acquisition, exceed 20% of our common stock outstanding prior to the Kolltan Acquisition. To the extent a Milestone is achieved and we elect to pay the corresponding Milestone Payment in shares of our common stock, the shares would be valued pursuant to a formula based on the then-market price of our common stock, as described below.

        Pursuant to the Merger Agreement, we agreed to seek stockholder approval at our next stockholders meeting following the execution of the Merger Agreement for the possible issuance of shares of our common stock pursuant to the Merger Agreement in excess of 19.99% of our outstanding shares.


What will behappen if stockholder approval is not obtained to issue shares of common stock in connection with Milestone Payments?considered at the Annual Meeting is described above and in our proxy statement.

        We believe that the proposals for the election of directors, ratification of our independent registered public accounting firm and the amendment to our Certificate of Incorporation to change the corporation's name are considered to be “routine” matters, and henceIf we do not obtain stockholder approval to issue common stock in connection with Milestone Payments, pursuant to the Merger Agreement, we would not be able to make Milestone Payments in shares of common stock to the extent Milestones are achieved resulting in stock payments aggregating to a 20% issuance in connection with the Kolltan Acquisition. In the event we do not have stockholder authorization to pay the Milestone Payments in common stock, and we instead elected to make Milestone Payments in cash we expect we would have to raise additional financing to pay such Milestone Payments in cash.

        Furthermore, in the event this proposal is not approved, we intend to solicit such approval at next year's annual meeting.

What will happen if stockholder approval is obtained and we issue additional shares of common stock in connection with Milestone Payments?

        If stockholder authorization is obtained to issue in connection with the Kolltan Acquisition common stock in excess of 20% of our outstanding shares, and (i) assuming all $172.5 million of Milestone Payments were to become payable and we elected to pay all such Milestone Payments in shares of our common stock, and (ii) further assuming a market price of $3.30, based on the closing price of our common stock on April 10, 2017, then, we would issue to the former securityholders of Kolltan (except with respect to non-accredited former shareholders of Kolltan to whom we will pay cash) in connection with such Milestone Payments an aggregate of 52,272,727 shares of our common stock, or approximately 42% of our outstanding shares as of April 10, 2017. The actual number of shares that theremay become issuable as Milestone Payments will depend on multiple factors including the Milestones that are actually achieved, the amount of the corresponding Milestone Payments that we elect to pay in shares of our common stock, and the market price of our common stock at the time that we pay the corresponding Milestone Payment in shares of our common stock. For purposes of the Milestone Payments, our common stock will be a significant numbervalued based on the average closing price per share of broker non-votes on these proposals.our common stock for the five trading day period ending three calendar days prior to the achievement of the relevant Milestone. While we believe that having the ability to pay Milestone Payments in shares of common stock offers benefits to the Company and its stockholders, including conservation of cash, the payment of Milestone Payments in shares of common stock may cause substantial dilution to the equity interest of our current stockholders.

How are we soliciting this proxy?

        We are soliciting this proxy on behalf of our Board of Directors by mail and will pay all expenses associated therewith. Some of our officers and other employees also may, but without compensation other than their regular compensation, solicit proxies by further mailing or personal conversations, or by telephone, facsimile or other electronic means. In addition, we have retained Georgeson LLC to assist in the solicitation of proxies and to provide related corporate governance services and informational support. We expect to pay Georgeson approximately $35,000 for their services and reimburse them for their out-of-pocket costs. We will also, upon request, reimburse brokers and other persons holding stock in their names, or in the names of nominees, for their reasonable out-of-pocket expenses for forwarding proxy materials to the beneficial owners of the capital stock and to obtain proxies.


-6-



PROPOSAL 1: TO ELECT SEVENEIGHT DIRECTORS TO SERVE UNTIL THE NEXT
ANNUAL MEETING
AND UNTIL THEIR SUCCESSORS HAVE BEEN DULY
ELECTED AND QUALIFIED

(Proposal (Proposal No. 1)

        At the Annual Meeting, seveneight directors are to be elected. All directors of the Company hold office until the next Annual Meeting of Stockholders or until their respective successors are duly elected and qualified or their earlier resignation or removal.

        It is the intention of the persons named in the proxies for the holders of common stock to vote the proxies for the election of the nominees named below, unless otherwise specified in any particular proxy. Our management does not contemplate that the nominees will become unavailable for any reason, but if that should occur before the meeting, proxies will be voted for another nominee, or other nominees, to be selected by our Board of Directors. In accordance with our by-laws and Delaware law, a stockholder entitled to vote for the election of directors may withhold authority to vote for certain nominees for directors or may withhold authority to vote for all nominees for directors. TheEach director nominees receivingnominee must be elected by a pluralitymajority of the votes of the holders of shares of common stock presentcast in person or by proxy at the meeting and entitledAnnual Meeting. Nominees are elected by a majority vote for non-contested director elections. Because the number of nominees properly nominated for the Annual Meeting is the same as the number of directors to vote onbe elected, the election of directors will be elected directors.at this Annual Meeting is non-contested. Broker non-votes will not be treated as a vote for or against any particular director nominee and will not affect the outcome of the election. Stockholders may not vote, or submit a proxy, for a greater number of nominees than the seveneight nominees named below.

Nominees for Election

        The persons listed below are our current directors and have been nominated for re-election or nominated for election at the Annual Meeting (the "Director Nominees") to fill the seveneight director positions to be elected by the holders of the common stock.

  Year First 
  Became 
Directors Age Director 
   
Charles R. Schaller 72 2008 
Herbert J. Conrad 75 2008 
Larry Ellberger 60 2003 
George O. Elston 43 2008 
Karen Shoos Lipton 54 2001 
Dr. Rajesh B. Parekh 47 2008 
Harry H. Penner, Jr. 63 1997 

-7-


Directors
 Age Year First
Became
Director
 

Larry Ellberger (Chairman of the Board)

  69  2003 

Anthony S. Marucci (Chief Executive Officer)

  55  2008 

Keith L. Brownlie

  64  Nominee 

Herbert J. Conrad

  84  2008 

James J. Marino

  67  2017 

Gerald McMahon

  62  2016 

Harry H. Penner, Jr. 

  71  1997 

Karen L. Shoos

  63  2001 

        The following biographical descriptions set forth certain information with respect to the Director Nominees, based on information furnished to AVANTCelldex by each Director Nominee.

Director Nominees

        Charles R. SchallerLarry Ellberger became thewas appointed Chairman of the Board of Directors of AVANT upon consummation of the Merger with Celldex. Mr. Schaller had been Chairmanin September 2009 and a director of Celldex since November 2006. Since 1989, Mr. Schaller has been a chemical industry venture developer and, until June 2002, he served as a director of AstroPower, a prominent independent U.S. manufacturer of photo-voltaic (PV) products until being acquired by General Electric. Mr. Schaller also has been a Director of Medarex, Inc., an affiliate of Celldex, since 1987, and was Chairman of the Medarex Board of Directors from 1987 to 1997. Mr. Schaller is a graduate of Yale University and is a graduate of the program in management development at Harvard Business School.

Herbert J. Conradbecame a director of AVANT upon consummation of the Merger with Celldex. Mr. Conrad had been a director of Celldex since March 2004.August 2003. Mr. Conrad is currently theEllberger was formerly Chairman of the Board of Directors of Sapphire Therapeutics, a Director of Savient Pharmaceuticals and Symphony Evolution and serves on the Medical Advisory Board of Henry Schein.Omrix BioPharmaceuticals, Inc. until its acquisition by Johnson & Johnson in 2008. From 19602003 to 1993 Mr. Conrad was with Hoffmann La Roche where he was President of the U.S. Pharmaceuticals Division from 1982 through 1993. Mr. Conrad earned his undergraduate and graduate degrees from the Brooklyn College of Pharmacy. He also received a Doctorate in Humane Letters (honorary) from Long Island University.

Larry Ellberger.July 2012, Mr. Ellberger has been a directorwas Founding Partner of AVANT since August 2003. He is a Founder and Principal of Healthcare Ventures Associates,HVA, Inc., a consulting firm specializing in business development, product acquisition and licensing, and mergers and acquisitions for the pharmaceutical, biotechnology, drug delivery and medical device industries. Hecompanies. From October 2005 to May 2006,


Mr. Ellberger was most recently Interim Chief Executive Officer of PDI, Inc., a diversifiedprovider of sales and marketing services provider to the biopharmaceutical medical deviceindustry. Previously, he was a member of the Board of Directors of PDI and diagnostic industries.Chairman of the Audit Committee. From 2000 to 2003, heMr. Ellberger was Senior Vice President and a member of the Board of Directors of Powderject plc. He also served asPLC, a director of Powderject.U.K. vaccine company. From 1995 to 1999, Mr. Ellberger was withheld several senior executive positions at W.R. Grace & Co. from 1995 to 1999, serving asincluding Interim Chief Executive Officer, Chief Financial Officer from 1996 and Senior Vice President, Strategic Planning and Development from 1995, and Acting Chief Executive Officer in 1997.Development. From 1975 to 1995, Mr. Ellberger held numerous senior executive positions at American Cyanamid Company, serving the last four years as Vice President, Corporate Development. Mr. Ellberger currently serves on the Board of Directors and is a member of Omrix BioPharmaceuticals, Inc.the Audit and Nominating Committees of NeuroDerm, Ltd., Transpharma, Ltd. anda NASDAQ-listed Israeli biotech company. He is also a Director of The Jewish Children’sChildren's Museum. Mr. Ellberger received a B.A. in Economics from Columbia College and a B.Sc. in Chemical Engineering from Columbia School of Engineering.

        George O. ElstonAnthony S. Marucci became a directorwas appointed as permanent President and Chief Executive Officer of AVANT upon consummation of the Merger with Celldex. Mr. Elston had beenCelldex in September 2008 and as a director of Celldex since March 2004 and is currently thein December 2008. Since May 2003, Mr. Marucci has held a number of roles with Celldex, including as a founder, Vice President, Chief Financial Officer, Treasurer and Secretary. In addition, he was Treasurer of Optherion,Medarex, Inc. (now a part of Bristol Myers Squibb Co.) from December 1998 to March 2004. Mr. Marucci held a series of senior financial positions at Medarex from December 1998 to May 2003. Mr. Marucci is a member of the Board of Trustees of BioNJ Inc. and also served as its Treasurer through 2010. Mr. Marucci is a member of the Board of the College of Business and Public Management at Kean University. Mr. Marucci received his M.B.A. from Columbia University and his Executive Master of Healthcare Leadership from Brown University.

Keith L. Brownlie was nominated for election to our Board of Directors in March 2017. Mr. Brownlie was employed by the accounting firm Ernst & Young LLP from 1974 to 2010. At Ernst & Young, he served as audit partner for numerous public companies and was the Life Sciences Industry Leader for the New York Metro Area. Since his retirement from Ernst & Young in 2010, Mr. Brownlie has served as a member of the board of directors and chairman of the audit committee of Soligenix, Inc., a privately heldpublicly-held biopharmaceutical company located in New Haven, CT.company. Since 2012, Mr. ElstonBrownlie has more than 20 yearsserved as a member of financialthe board of directors and business expertise inserved as the biotechnologychairman of the audit committee of RXi Pharmaceuticals Corporation, a publicly-held biopharmaceutical company. From 2011 to 2013, Mr. Brownlie also served as a member of the board of directors and medical device industries. Before joining Optherion,served as the chairman of the audit committee of EpiCept Corporation, a publicly-held biopharmaceutical company. From 2013 to 2014, Mr. ElstonBrownlie was with Elusys Therapeutics where he raised significant funding from governmenta member of the board of directors and private sources, completed multiple strategic collaborations with large pharmaceutical and biotechnology firms, and oversaw collaborations withserved as the U.S. Departmentchairman of Defense and the National Institutesaudit committee of Health. Before joining Elusys, Mr. Elston was Chief Financial Officer of Trillium USA,Cancer Genetics, Inc., where he established the financial and administrative functions for the Company’s multi-national operations. Previously,a publicly-held biopharmaceutical company. Mr. Elston was with C.R. Bard, Inc., an international manufacturer and distributor of medical devices, where he directed financial operations for multiple manufacturing facilitiesBrownlie received a B.S. in several countries and successfully integrated strategic acquisitions; and with Price Waterhouse. Mr. Elston received his BBA in Public Accounting from PaceLehigh University and is a Certified Public Accountant.

-8-Herbert J. Conrad became a director of Celldex in March 2008 upon consummation of the AVANT Merger. Mr. Conrad had been a director of Celldex Research since March 2004. Mr. Conrad was President of the U.S. Pharmaceuticals Division of Hoffmann-La Roche, Inc., a pharmaceutical company, from 1982 until his retirement in 1993. Mr. Conrad currently serves as Chairman of the Board of Matinas BioPharma Holdings, Inc., a publicly-held biopharmaceutical company and a director of Arbutus Biopharma Corporation, a publicly-held biopharmaceutical company. Mr. Conrad serves as an Advisor to the Seaver Autism Center at Mount Sinai Hospital. In addition to serving on the board of directors of privately held biotechnology companies, Mr. Conrad has served as Chairman of the Board of Directors of Pharmasset, Inc., GenVec, Inc. and Bone Care International, Inc. Mr. Conrad has also served as director of Savient Pharmaceuticals, Inc. and was a director and co-founder of Reliant Pharmaceuticals, Inc. He received B.S. and M.S. degrees from the Brooklyn College of Pharmacy and an honorary Doctorate in Humane Letters from Long Island University.


        Karen Shoos LiptonJames J. Marino. Ms. Lipton became a director of Celldex in March 2017. Mr. Marino has served as a member of the board of directors of Onconova Therapeutics, Inc., a publicly-held biopharmaceutical company,


since July 2015. Prior to July 2015, Mr. Marino was a Partner at the global law firm of Dechert LLP for 28 years, where he served as Managing Partner of the Princeton Office. Previously, he served on the board of directors of Pharmacopeia Inc. and has worked in advisory capacities and on the boards of multiple non-profit organizations, including Robert Wood Johnson University Hospital. He currently serves on the Board of Trustees of Wake Forest University and Wake Forest University Baptist Medical Center. Mr. Marino received his B.A., M.B.A., and J.D. from Rutgers University.

Gerald McMahon became a director of Celldex in December 2016. Since December 2016, Dr. McMahon has been President and Chief Executive Officer of Harpoon Therapeutics, Inc., a private biopharmaceutical company. Prior to Celldex's acquisition of Kolltan, Dr. McMahon served as President and Chief Executive Officer and a member of the board of directors of Kolltan, a private biopharmaceutical company. Prior to joining Kolltan, Dr. McMahon served as Senior Vice President of Oncology at MedImmune LLC, a wholly owned subsidiary of the healthcare company AstraZeneca AB, or AstraZeneca, from October 2010 to May 2012. From 2006 to 2008, Dr. McMahon served as the Chairman and Chief Executive Officer of the pharmaceutical company NeoRx Corp. From 2008 to 2011, Dr. McMahon served as the Chairman and Chief Executive Officer of Poniard Pharmaceuticals, Inc. Previously, Dr. McMahon served as a business executive in the healthcare and biotechnology industries at companies such as Pfizer Inc., Pharmacia Corporation, and Sandoz, Inc. Dr. McMahon also previously served as President of Sugen Inc., a pharmaceutical company. Dr. McMahon holds a B.S. in biology and a Ph.D. in biochemistry from Rensselaer Polytechnic Institute. In addition, Dr. McMahon has served as a member of the board of directors of Mateon Therapeutics, Inc., a publicly-held biopharmaceutical company, formerly known as OXiGENE, Inc. since September 2011.

Harry H. Penner, Jr. has been a director of Celldex since January 1997 and was Chairman of AVANT prior to the consummation of the AVANT Merger. Mr. Penner has served as Chairman and Chief Executive Officer of Nascent BioScience, LLC, a firm engaged in the creation and development of new biotechnology companies since 2001. From 1993 to 2001, Mr. Penner was President, Chief Executive Officer and Vice Chairman of Neurogen Corporation. From 1985 to 1993, Mr. Penner was an Executive Vice President of Novo Nordisk A/S, serving from 1988 to 1993 as Executive Vice President for North America and President, Novo Nordisk of North America, and from 1985 to 1988 as the company's Executive Vice President and General Counsel in Denmark. He has served as BioScience Advisor to the Governor and the State of Connecticut, as Co-Chairman of Connecticut United for Research Excellence, and as Chairman of the Connecticut Board of Governors of Higher Education and the Connecticut Technology Council. In addition to having served on the board of directors of several public and privately held life science companies, Mr. Penner is currently on the Board of Directors of Prevention Pharmaceuticals, Inc., Affinimark Technologies, Inc., Neurovail, Inc. and Aria Neurosciences, Inc., all of which he is a founder. Mr. Penner received a B.A. from the University of Virginia, a J.D. from Fordham University, and an L.L.M. in International Law from New York University.

Karen L. Shoos has been a director of Celldex since May 2001. Ms. LiptonShoos is currently a consultant in AABB's Division of Global Services. From May 2013 to September 2016, Ms. Shoos was appointedPrincipal Investigator, AABB International Technical Assistance. From October 1994 to May 2013, Ms. Shoos was Chief Executive Officer of AABB. AABB is a professional standards setting and accrediting organization in the American Associationfields of Blood Banks (dba AABB) in October 1994. Previously she hasblood and cellular therapies. Prior to AABB, from 1984 to 1994, Ms. Shoos held senior positions at the American Red Cross, since 1984, including Acting Senior Vice President, Biomedical Services (1993-1994) and Secretary and General Counsel (1990-1993). Prior to the American Red Cross, Ms. LiptonShoos was a lawyer in private practice. Ms. Shoos earned her B.A. from Yale University and her J.D. from Case Western Reserve University.


Dr. Rajesh B. Parekh became a director of AVANT upon consummation of the Merger with Celldex. Dr. Parekh had been a director of Celldex since March 2004 and has been a General Partner at Advent Venture Partners (UK) since 2006. Prior to joining Advent, Dr. Parekh was an Entrepreneur-in-Residence at Abingworth Management Limited (UK) from 2003-2005. Dr. Parekh has also been a Visiting Professor at the University of Oxford. He was a co-founder and served as Chief Scientific Officer and Senior Vice President of Research and Development of Oxford GlycoSciences, plc (UK) from 1988 to 2003. Dr. Parekh has been chairman of Galapagos NV (Belgium) since 2004 and currently serves on the boards of directors of seven companies including private companies in the United States and Europe and one public European company. He received his B.A. and D. Phil. degrees in Biochemistry and Molecular Medicine from the University of Oxford.

Harry H. Penner, Jr.Mr. Penner has been a director of AVANT since January 1997 and was Chairman of AVANT prior to the Merger with Celldex. He is Chairman and Chief Executive Officer of Nascent BioScience, LLC, a firm which has been instrumental in the founding and development of a number of new biotechnology companies, including Rib-X Pharmaceuticals, Inc., Marinus Pharmaceuticals, Inc., RHEI Pharmaceuticals, Inc., RxGen Inc., Affinimark Technologies, Inc., and MAK Scientific. He has served as BioScience Advisor to the Governor of the State of Connecticut, and as Chair of the Connecticut Board of Governors of Higher Education, CURE, the Connecticut BioScience Cluster, and the Connecticut Technology Council. From 1993 to 2001, Mr. Penner was President and CEO of Neurogen Corporation. He served as Executive Vice President of Novo Nordisk A/S from 1985 to 1993 and President of Novo Nordisk of North America, Inc. from 1988 to 1993. He serves on the boards of Altus Pharmaceuticals, Inc., Ikonisys, Inc. Rib-X, Marinus, Rhei, and RxGen. Mr. Penner holds degrees from the University of Virginia (BA), Fordham University (JD), and New York University (LLM).

Family Relationships

There are no family relationships among our Director Nominees, management and other key personnel.

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The Board of Directors and Its Committees

Board of Directors. AVANT is

        We are currently managed by a sevenan eight member Board of Directors, eacha majority of whom are “independent”"independent" as that term is defined in the applicable NASDAQ listing standards. During 2007, three membersOther than Mr. Marucci and Dr. McMahon, each of our Board of Directors resigned.directors is deemed "independent" as that term is defined in the applicable NASDAQ listing standards. Our Board of Directors met eightnine times in 2007.2016. Each of the directors attended at least 75% of the aggregate of (i) the total number of meetings of our Board of Directors (held during the period for which such directors served on the Board of Directors) and (ii) the total number of meetings of all committees of our Board of Directors on which the Director served (during the periods for which the director served on such committee or committees). Our annual meeting of stockholders is generally held to coincide with one of the Board’sBoard's regularly scheduled meetings. AVANT doesWe do not have a formal policy requiring members of the Board of Directors to attend our annual meetings, although allour directors typically attend the annual meeting. Each of the then current directors attended the 2007 annual meeting2016 Annual Meeting of stockholders. As of March 7, 2008, following consummation of the Merger, four former Celldex directors joined our Board of Directors: Charles R. Schaller, George O. Elston, Herbert J. Conrad, and Dr. Rajesh B. Parekh.Stockholders.

Audit Committee

Audit Committee.        The Board of Directors has established an Audit Committee currently consisting of George O. Elston, Chair, Larry Ellberger Chairman,and Harry H. Penner, Jr., and George O. Elston. During 2007, Peter A. Sears and Francis Cano also were members of Mr. Elston's term as director will expire at the 2017 Annual Meeting. Following the 2017 Annual Meeting, Mr. Brownlie is expected to be appointed to the Audit Committee prior to their resignations.Committee. The Audit Committee makes recommendations concerning the engagement of independent public accountants, reviews with the independent public accountants the scope and results of the audit engagement, approves professional services provided by the independent public accountants, reviews the independence of the independent public accountants, considers the range of audit and non-audit fees, and reviews the adequacy of our internal accounting controls. Each member of the Audit Committee is “independent”"independent" as that term is defined in the rules of the Securities and Exchange CommissionSEC and the applicable NASDAQ listing standards. The Board of Directors has determined that each Audit Committee member has sufficient knowledge in financial and auditing matters to serve on the Committee. The Board of Directors has designated Messrs. Ellberger andGeorge O. Elston as “auditan "audit committee financial experts,”expert," as defined under the applicable rules of the Securities and Exchange CommissionSEC and the applicable NASDAQ listing standards. The Audit Committee met eightsix times during 2007.2016. Our Board of Directors has adopted an Audit Committee Charter, which is available for viewing at www.avantimmune.com.www.celldex.com.

Compensation Committee.

        The Board of Directors has established a Compensation Committee currently consisting of Dr. Rajesh B. Parekh, Chairman,James J. Marino, Chair, Herbert J. Conrad and Harry H. Penner, Jr. and Charles R. Schaller. During 2007, Peter A. Sears, Alf Lindberg and Francis Cano also were members of the Compensation Committee prior to their resignations. The primary function of the Compensation Committee is to assist the Board of Directors in the establishment of compensation for the Chief Executive Officer, and, upon her recommendation, to approve the compensation of other officers and senior employees and to approve certain other personnel and employee benefit matters. Each member of the Compensation Committee is "independent" as that term is defined in the rules of the SEC and the applicable NASDAQ listing standards. In 2016, the Compensation Committee engaged Radford, an Aon Hewitt Company, to provide guidance on various aspects of the company's board and executive compensation programs. The Compensation Committee has assessed the independence of Radford and concluded that no conflict of interests exists under applicable SEC rules. The Compensation Committee met fourten times during 2007. 2016.


Our Board of Directors has adopted a Compensation Committee Charter, which is available for viewing at www.avantimmune.com. Each member of the Compensation Committee is “independent” as that term is defined in the rules of the Securities and Exchange Commission and the applicable NASDAQ listing standards.www.celldex.com.

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Nominating and Corporate Governance Committee

.        The Board of Directors has established a Nominating and Corporate Governance Committee currently consisting of Karen L. Shoos, Chair, Herbert J. Conrad Chairman, Karen Shoos Lipton and Charles R. Schaller. Alf Lindberg, also was a member of the Nominating and Corporate Governance Committee in 2007 prior to his resignation.Larry Ellberger. The primary function of the Nominating and Corporate Governance Committee is to assist the Board of Directors in reviewing, investigating and addressing issues regarding composition of the Board of Directors,composition, policy and structure; membership on the committees of the Board of Directors;committees; and other matters regarding the governance of AVANT. The Nominating and Corporate Governance Committee met once during 2007. Our Board of Directors has adopted a Nominating and Corporate Governance Charter, which is available for viewing at www.avantimmune.com.our governance. Each member of the Nominating and Corporate Governance Committee is “independent”"independent" as that term is defined in the rules of the Securities and Exchange CommissionSEC and the applicable NASDAQ listing standards. The Nominating and Corporate Governance Committee met five times during 2016. Our Board has adopted a Nominating and Corporate Governance Committee Charter, which is available for viewing atwww.celldex.com.

Director selection criteria

        The Nominating and Corporate Governance Committee is responsible for reviewing, on an annual basis, the appropriate mix of professional competencies, key attributes, skills and experiences required of board members to work together as a team to properly oversee our strategies and operations. The process followed by the Nominating and Corporate Governance Committee to identify and evaluate any candidates includes (i) the review of requests fromwhether identified or recommended by board members, of the Board of Directors, management, members of the Nominating and Corporate Governance Committee, stockholders andor other external sources; (ii)sources, includes meetings from time to time to evaluate biographical information and background material relating to potential candidates to the Board;Board and (iii) interviews of selected candidates by members of the Committee and the Board. All nominees must have, at a minimum, high personal and professional integrity, exceptional ability and judgment, and be effective in collectively serving the long-term interests of all stockholders.stockholders, all as described above. Other qualifications that may be considered by the Committee are described in the Nominating and Corporate Governance Committee Charter.

        StockholdersAll board members are expected to possess certain key attributes necessary to creating a functional board: high personal and professional ethics, integrity and values; practical wisdom and mature judgment; an inquisitive and objective perspective; professional experience at a policy-making level in business, government, education or medicine; time availability for in-person participation at board and committee meetings; and a commitment to representing the long-term interests of our stockholders. We look for directors with professional competencies that include senior management operational experience, accounting and finance capabilities, deep industry-related experience, biologic development and manufacturing expertise, business development leadership, medical and scientific proficiencies, and government and public policy experience.

        Each of our directors brings unique perspectives and experiences to the Board of Directors and contributes in guiding and directing our strategies to meet our business objectives and to provide value to our stockholders. For example, Mr. Conrad, Mr. Ellberger, Mr. Marucci, Dr. McMahon, Mr. Penner and Ms. Shoos have all either currently or formerly been chief executive officers of life sciences or healthcare-related companies and have experienced the challenges of such a position. Messrs. Ellberger and Marucci have formerly been chief financial and chief corporate development officers at pharmaceutical and life sciences companies and have completed a significant number of financing and business development transactions. Ms. Shoos has experience in the highly regulated blood supply and cellular therapies sectors, which are similar to our regulated biologics industry. Mr. Penner has been the chief legal officer at a large public pharmaceutical company and for that company and for life sciences companies has completed a significant number of financing and business development transactions. Mr. Marino, as partner at a large law firm, focused his practice on representing public and private life sciences companies and has extensive experience advising his clients in the full range of


corporate, transactional, finance, compliance and governance matters. Mr. Brownlie, as partner at an international public accounting firm and leader of the firm's regional life sciences industry practice, and as chairman of the audit committees of other publicly-traded biopharmaceutical companies, has developed a deep knowledge of the life sciences industry and the relevant public company accounting standards and regulations and is deemed a "Financial Expert" under the Sarbanes-Oxley Act as that term is defined by the SEC. Messrs. Brownlie, Conrad and Ellberger have many years of experience on the boards of directors of larger public pharmaceutical and life sciences companies.

        Independence also is an important selection criterion for nomination to our Board. Independent directors should be free of any relationship with us, our management, other directors or other parties that may recommend individualsimpair, or appear to impair, the director's ability to make independent judgments. Independent directors must satisfy the criteria for independence established by NASDAQ. Currently all of our directors are independent except for our Chief Executive Officer, Mr. Marucci, and Dr. McMahon.

        Additionally, all board members are expected to act in our best interests and the best interests of our stockholders and to avoid any conflicts of interest in accordance with our Code of Business Conduct and Ethics. In selecting director nominees, the Nominating and Corporate Governance Committee seeks individuals who are free from conflicts of interest.

        Finally, candidates should be enthusiastic and excited about their service on our Board and working collaboratively with existing board members to create value for all of our stockholders.

Stockholder nominations for directorships

        Stockholders may propose a potential director candidate for consideration as potential director candidatesby the Nominating and Corporate Governance Committee by submitting their names and background to the Secretary of AVANTCelldex at the address set forth below under “Stockholder Communications.”Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827. All such recommendations will be forwarded to the Nominating and Corporate Governance Committee, which will review and consider only such recommendations if appropriate biographical and other information is provided, as described below, on a timely basis. All securityholdersecurity holder recommendations for director candidates must be submitted to AVANTus not less than 120 calendar days prior to the date on which AVANT’sour proxy statement wasis released to stockholders in connection with the previous year’sour annual meeting, and must include the following information:

  • the name and address of record of the securityholder;security holder;

  • a representation that the securityholdersecurity holder is a record holder of AVANTsour securities, or if the securityholdersecurity holder is not a record holder, evidence of ownership in accordance with Rule 14a-8(b)(2) of the Securities Exchange Act of 1934;

  • the name, age, business and residential address, educational background, current principal occupation or employment, and principal occupation or employment for the preceding five (5) full fiscal years of the proposed director candidate;

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  • a description of the qualifications and background of the proposed director candidate which addresses the minimum qualifications and other criteria for membership on the Board of Directorsmembership approved by the Board of Directors from time to time and set forth in the Nominating and Corporate Governance Committee’s written charter;Committee Charter;

  • Aa description of any arrangements or understandings between the securityholdersecurity holder and the proposed director candidate; and

  • The
    the consent of the proposed director candidate to be named in the proxy statement relating to AVANT’sour annual meeting of stockholders and to serve as a director if elected at such annual meeting.

        Assuming that appropriate information is provided for candidates recommended by stockholders, the Nominating and Corporate Governance Committee will evaluate those candidates by following substantially the same process, and applying substantially the same criteria, as for candidates submitted by members of the Board of Directorsmembers or other persons, as described above and as set forth in its written charter.

Board Leadership Structure

        The Board recognizes that one of its key responsibilities is to evaluate and determine its optimal leadership structure so as to provide independent oversight of management. The Board understands that there is no single, generally accepted approach to providing Board leadership and that given the dynamic and competitive environment in which we operate, the right Board leadership structure may vary as circumstances warrant. Consistent with this understanding, the Nominating and Corporate Governance Committee considers the Board's leadership structure on an annual basis. This consideration includes the pros and cons of alternative leadership structures in light of the Company's operating and governance environment at the time, with the goal of achieving the optimal model for effective oversight of management by the Board. Currently, the roles of Chief Executive Officer and Chairman of the Board are separate. Mr. Marucci, our Chief Executive Officer, is a member of our Board. Mr. Ellberger, an independent director, serves as Chairman of the Board. The Board believes that its current leadership structure provides independent board leadership, engagement and oversight.

        In addition, our independent committee chairs are responsible for leading committee meetings, determining committee meeting schedules, agenda and information flow, and reporting to the full Board on the committee's actions and areas of responsibilities.

Risk Oversight

        Our management is responsible for assessing and managing risk and the Board of Directors oversees and reviews certain aspects of our risk management processes. The Board of Directors is involved in risk oversight through direct decision-making authority with respect to significant matters and the oversight of management by the Board of Directors and its committees. The Board is responsible for overseeing risks related to our overall operations and strategy, including, among others, product development, potential asset acquisitions, financial reporting, business continuity (including succession planning) and reputational risks faced by us.

        The committees of the Board execute their oversight responsibility for risk management as follows:

    The Audit Committee is responsible for overseeing our internal financial and accounting controls and the work performed by the independent registered public accounting firm. As part of its oversight function, the Audit Committee regularly discusses with management and the independent registered public accounting firm our major financial and controls-related risk exposures and steps that management has taken to monitor and control such exposures. The Audit Committee also reviews our risk management insurance programs.

    The Compensation Committee is responsible for overseeing risks related to our cash and equity-based compensation programs and practices. As part of its oversight function, the Compensation Committee periodically discusses with the President and Chief Executive Officer as well as the Board of Directors, as necessary, the compensation plan for both executive officers and the independent directors, performance goals and objectives for the period and related achievement, peer group and other relevant compensation benchmarks and practices and other matters to ensure our compensation practices are in our best interest and that of our shareholders.

    The Nominating and Corporate Governance Committee is responsible for overseeing risks related to the composition and structure of the Board of Directors and its committees and our corporate governance. In this regard, the Nominating and Corporate Governance Committee

      assesses the qualifications and independence of members of the Board, makes annual recommendations regarding Board and committee membership, and reviews any transactions between us and our officers, directors, affiliates of officers and directors or other related parties for conflicts of interest.

Corporate Governance Matters

        Upon the recommendation of our Nominating and Corporate Governance Committee, we adopted amended and restated by-laws to among other things replace with plurality voting standard with a majority voting standard for uncontested elections of directors and eliminate the mandatory retirement age for directors. Since it is an uncontested election at this Annual Meeting, all director nominees are required to receive a number of "FOR" votes representing at least a majority of votes cast in the election. If such a director nominee fails to receive "FOR" votes representing at least a majority of votes cast and is an incumbent director, the by-laws require the director to promptly tender his or her resignation to the Board, subject to acceptance by the Board. The Nominating and Corporate Governance Committee of the Board would then be charged with making a recommendation to the Board as to whether to accept or reject the tendered resignation, or whether other action should be taken. In contested elections, where the number of nominees exceeds the number of directors to be elected, the plurality voting standard would continue to apply.

        In addition, upon the recommendation of our Nominating and Corporate Governance Committee, we adopted corporate governance guidelines which are posted to our corporate website.

Stockholder Communications

        The Board of Directors will give appropriate attention to written communications that are submitted by stockholders, and will respond if and as appropriate. Absent unusual circumstances or as contemplated by committee charters, and subject to advice from legal counsel, the Secretary of AVANTCelldex is primarily responsible for monitoring communications from stockholders and for providing copies or summaries of such communications to the Board of Directors as he considers appropriate.

        Communications from stockholders will be forwarded to all directors if they relate to important substantive matters or if they include suggestions or comments that the Secretary considers to be important for the Board of Directors to know. Communication relating to corporate governance and corporate strategy are more likely to be forwarded to the Board of Directors than communications regarding personal grievances, ordinary business matters and matters as to which AVANTCelldex tends to receive repetitive or duplicative communications.

        Stockholders who wish to send communications to the Board of Directors should address such communications to: The Board of Directors, AVANT Immunotherapeutics,Celldex Therapeutics, Inc., 119 Fourth Avenue, Needham, Massachusetts 02494,Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827, Attention: Secretary.

Code of Business Conduct and Ethics

        We have adopted a Code of Business Conduct and Ethics that applies to our directors, officers and employees. The purpose of the Code of Business Conduct and Ethics is to deter wrongdoing and to promote, among other things, honest and ethical conduct and to ensure to the extent possible that our business is conducted in a consistently legal and ethical manner. Our Code of Business Conduct and Ethics is publicly available on our website atwww.avantimmune.com.at www.celldex.com. If we make any substantive amendments to the Code of Business Conduct and Ethics or grant any waiver, including any implicit waiver from a provision of the Code of Business Conduct and Ethics to our Directors or Executive Officers, we will disclose the nature of such amendments or waiver on our website or in a current report on Form 8-K.


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Executive Officers

The following table sets forth certain information regarding our current executive officers(1):officers:

Name of Individual
AgePosition and Office

Anthony S. Marucci

 45 

Interim

55President, Chief Executive Officer and President and Executive Vice President, Corporate Development

Director

Avery W. Catlin

 60 

69Senior Vice President, Chief Financial Officer and Secretary

Dr. Elizabeth Crowley

45Senior Vice President and Chief Product Development Officer

Thomas Davis, M.D. 

 44 

Senior

53Executive Vice President and Chief Medical Officer

Tibor Keler, Ph.D. 

 45 

Senior

58Executive Vice President and Chief Scientific Officer

Dr. Ronald C NewboldTheresa LaVallee, Ph.D. 

 45 

50Senior Vice President, Regulatory and Precision Medicine

Ronald Pepin, Ph.D. 

61Senior Vice President and Chief Business DevelopmentOfficer

Richard Wright, Ph.D. 

53Senior Vice President and Chief Commercial Officer

(1)Una S. Ryan served as our Chief Executive Officer and President until her resignation on May7, 2008. Hence, Dr. Ryan is a Named Executive Officer for purposes of the Executive Compensation disclosure herein but does not appear in the above table of current executive officers. Timothy Cooke, Ronald W. Ellis, and Dr. Keilani served as our Chief Operating Officer, Senior Vice President - Research and Development and Vice President – Medical and Regulatory Affairs, respectively, until their respective resignations on February 11, 2008, July 31, 2007 and April 17, 2008. Hence, Messrs. Cooke and Ellis are Named Executive Officers for purposes of the Executive Compensation disclosure herein but do not appear in the above table of current executive officers. Henry C. Marsh, Jr. was considered an executive officer prior to the Merger and hence appears in the Executive Compensation Tables but not in the above table of current executive officers; Mr. Marsh has continued with the Company.

        Anthony S. Marucci became Executive Vicewas appointed as permanent President Corporate Development of AVANT upon consummation of the Merger with Celldex. Upon Dr. Ryan’s resignation, he also assumed the role of interimand Chief Executive Officer of Celldex in September 2008 and President of AVANT pending completionas a director of the Nominating and Corporate Governance Committee’s search process which will include a review of internal and external candidates. Prior to the Merger,Company in December 2008. See Mr. Marucci had been Celldex’s Acting Chief Executive Officer since October 2007 and its Vice President, Chief Financial Officer, Treasurer and Secretary since May 2003. Mr. Marucci was a founding officer of Celldex and led that company's acquisition of the business of Lorantis Limited, which included the program which became Celldex's CDX-110 program. In addition, he was Treasurer of Medarex from December 1998 to March 2004. Mr. Marucci held a series of senior financial positions at Medarex since December 1998. Mr. Marucci received his M.B.A. from Columbia University.Marucci's biography underDirector Nominees above.

        Avery W. Catlin. Mr. Catlin joined AVANTCelldex in January 2000. Mr. Catlin has more than 25 years of financial and business expertise in the biotechnology and medical device industries. Prior to joining AVANT,Celldex, he served as Vice President, Operations and Finance, and Chief Financial Officer of Endogen, Inc., a public life science research products company, from 1996 to 1999. From 1992 to 1996, Mr. Catlin held various financial positions at Repligen Corporation, a public biopharmaceutical company, serving the last two years as Chief Financial Officer. Earlier in his career, Mr. Catlin held the position of Chief Financial Officer at MediSense, Inc., a Massachusetts-based medical device company. Mr. Catlin currently serves on the Board of Directors of Corbus Pharmaceuticals Holdings Inc., a publicly-held biopharmaceuticals company, and is Chair of the Audit Committee. Mr. Catlin received his B.A. degree from the University of Virginia and his M.B.A. from Babson College and is a Certified Public Accountant. As previously disclosed in March 2017, Mr. Catlin has announced his intention to retire from Celldex on June 30, 2017.

-13-Elizabeth Crowley became Senior Vice President and Chief Product Development Officer in August 2016. Ms. Crowley served as Senior Vice President, Product Development of Celldex from July 2014 to August 2016. Ms. Crowley joined Celldex in 2009 as Vice President, Clinical Development. Prior to that, she held several senior level roles at CuraGen Corporation, most recently serving as the Vice President of Development Operations. Ms. Crowley started her career at Bayer Corporation in 1992, holding various positions providing leadership of clinical research and project management prior to completing her tenure there as the Director of Global Study Audit Management. Ms. Crowley received her B.S. in Chemistry with a concentration in Business from Boston College.


        Thomas Davis, MDM.D. became Executive Vice President and Chief Medical Officer of Celldex in July 2014. Dr. Davis served as Senior Vice President and Chief Medical Officer of AVANT upon consummation of the Merger with Celldex. Dr. Davis wasCelldex from March 2008 to July 2014 and as Vice President of Clinical Development and Chief Medical Officer of Celldex.Celldex from April 2006 to March 2008. Prior to Celldex, Dr. Davis was formerlyserved as Chief Medical Officer at GenVec andfrom July 2005 to April 2006. Dr. Davis was also Senior Director of Clinical Science at Medarex. HeDr. Davis has supervised clinical efforts in adult hematologic malignancies and marrow transplantation and therapeutic antibodies at the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI) and worked with Dr. Ron Levy on the development of rituximab and idiotype vaccines at Stanford University. Dr. Davis received his B.A. degree in Biophysics from Johns Hopkins


University, his M.S. degree in Physiology from Georgetown University and his M.D. from Georgetown University School of Medicine.

        Dr. Tibor Keler, Ph.D. became Executive Vice President and Chief Scientific Officer of Celldex in July 2014. Since, May 2003, Dr. Keler has held a number of positions with Celldex, including as a founder, Senior Vice President and Chief Scientific Officer of AVANT upon consummation of the Merger with Celldex. Dr. Keler had been a founding officer of Celldex, serving as itsfrom March 2008 to July 2014, and Vice President, Research and Discovery and Chief Scientific Officer, sincefrom May 2003.2003 to March 2008. In addition, he was Senior Director of Preclinical Development and Principal Scientist at Medarex Inc. from September 1993 to March 2004. While at Medarex, he was responsible for the development of Celldex’s technology and products, as well as for the preclinical development and testing of numerous Medarex products now in Phase II clinical trials. Dr. Keler received his Ph.D. in Microbiology from the University of Pennsylvania.

        Theresa LaVallee, Ph.D. became Senior Vice President, Regulatory and Precision Medicine in November 2016. From April 2013 to November 2016, Dr. LaVallee served as Kolltan's Senior Vice President, Translational Medicine. From April 2008 to April 2013, Dr. LaVallee served as Senior Director, Translational Medicine at MedImmune LLC, a wholly owned subsidiary of the healthcare company AstraZeneca. From 1998 to 2008, Dr. LaVallee served in a number of positions in the healthcare industry, including Senior Director, Cell Biology, at Casi Pharmaceuticals, Inc., formerly EntreMed Inc. Dr. LaVallee received a Ph.D. from the University of California, Los Angeles and a B.A. in Biochemistry from the University of California, Santa Barbara. Dr. LaVallee completed postdoctoral research at the American Red Cross Holland Laboratory. Dr. LaVallee has informed Celldex of her decision to relocate to the West Coast to be closer to family and, as such, has provided notice of her resignation which will be effective during the second quarter of 2017.

Ronald C. Newbold, Ph.DPepin, Ph.D..became Senior Vice President and Chief Business Officer of Celldex in July 2011. From June 2010 to April 2011, Dr. Pepin served as Vice President at Shire Pharmaceuticals. From August 2000 to December 2009, Dr. Pepin was Senior Vice President, Business Development at Medarex. Earlier in his career, Dr. Pepin was Executive Director of AVANT upon consummation of the Merger with Celldex.External Science and Technology at Bristol-Myers Squibb Company. Dr. Newbold wasPepin received his B.A. from Tufts University and his Ph.D. in Genetics from Georgetown University.

Richard Wright, Ph.D. became Senior Vice President and Chief Commercial Officer of Business Development of Celldex. Previously,Celldex in July 2015. Dr. Newbold was ExecutiveWright served as Vice President of Commercial Operations for Sentigen Biosciences (subsequently soldof Celldex from April 2012 to Invitrogen), following his prior position as SeniorJuly 2015. From November 2010 to April 2012, Dr. Wright was Managing Director of StrategicNavigant Consulting, a global life sciences consulting practice. From September 2003 to October 2010, Dr. Wright held several senior leadership roles at Bristol-Myers Squibb including Senior Vice President of the U.S. ImmunoScience Division. Dr. Wright currently serves on the Scientific Advisory Board for the Seaver Foundation, a nonprofit organization supporting the Center for Autism Treatment and Research Initiatives at Merck & Company, where he led Merck’s Technology Licensing groupMount Sinai Hospital. Dr. Wright received his B.S. in Biological Sciences from 1996-2004. Prior to joining Merck as a medicinal chemistRutgers University and his M.S. and Ph.D. in 1991, Dr. Newbold was a postdoctoral fellow at Harvard University, following doctoral studies in synthetic organic chemistry at theMicrobiology and Molecular Genetics from The University of Rochester.Medicine and Dentistry of New Jersey (Rutgers University). He received his MBAan M.B.A. in Marketing and Finance from Columbia University.


EXECUTIVE COMPENSATION

Compensation Discussion and Analysis (for fiscal year 2007

Introduction

        Our Compensation Committee oversees and administers our executive compensation programs. The Committee's complete roles and responsibilities are set forth in the written charter of AVANT priorthe Compensation Committee adopted by our Board of Directors, which can be found at our website,www.celldex.com.

Overview

        Our executive compensation programs are designed to deliver compensation that is competitive with our peer group and that allows us to attract and retain superior talent who can perform effectively and succeed in a demanding business environment. Our compensation programs are also designed to reward performance against pre-established goals and align the Merger)

Overview

interests of our executives with our stockholders. We believe that the compensation of our executive officers should focus executive behavior on the achievement of near-term corporate targets as well as long-term business objectives and strategies. We place significance on the data reported in the 2006 executive compensation survey of over 400 biotechnology companies independently prepared by Aon-Radford and onbelieve that pay-for-performance compensation programs, which reward our executives when wethey achieve certain financial and businessindividual and/or corporate goals, and create stockholder value.value and thus have emphasized company and individual performance in setting compensation. We use a combination of base salary, annual cash incentive compensation programs, a long-term equity incentive compensation program and a broad basedbroad-based benefits program to create a competitive compensation package for our executive management team. We describe below our compensation philosophy, policies and practices with respect to our Chief Executive Officer, Chief Financial Officer and our three most highly compensated executive officers, other than the Chief Executive Officer and Chief Financial Officer, who were serving as executive officers as of December 31, 2016, who are collectively referred to as our Named Executive Officers.

        As a biopharmaceutical company focusing on the development of several immunotherapy technologies, we establish corporate goals that are designed to contribute to the development of our lead programs and to ensure that we manage our cash effectively and have sufficient funding to complete near-term development activities for our lead drug candidates and, where appropriate, to pursue partnerships and collaborations through which we can leverage the value of our drug candidates. We seek to link the financial interests of our Named Executive Officers (as defined herein).to those of our stockholders by tying compensation to the achievement of these strategic corporate goals, which we believe will drive long-term stockholder value. Each year we establish corporate goals, the achievement of which we believe are essential to the long-term success of our business.

-14-        The Compensation Committee has adopted a compensation philosophy of targeting our executive compensation to the 50th percentile of executive compensation of our peer group and the Radford Global Life Sciences Survey results. Executive compensation may be above or below the 50th percentile based on an executive's experience, scope of position, individual performance and company constraints. The Compensation Committee increased the annual base salary for Mr. Marucci, Mr. Catlin, Dr. Davis and Dr. Keler by 2.0% to 3.5% in mid-2016, depending on the position. Ms. Crowley's annual base salary increased 6.0% upon her promotion to Senior Vice President and Chief Product Development Officer in August 2016.


        In December 2016 and February 2017, our Compensation Committee reviewed our performance relative to our 2016 corporate goals and concluded that we had achieved at least 80% of our pipeline development, business and financial operations goals, particularly with respect to progress in our lead clinical programs—our glembatumumab vedotin (or glemba) and varlilumab (or varli) programs. Our Compensation Committee approved annual bonus payments for our Named Executive Officers, which


resulted in a payout of 75.7% to 83.5% of our Named Executive Officers' 2016 bonus target, depending on the position. Further, stock options granted to our executive officers in 2016 have exercise prices equal to 100% of the fair value on the date of grant and vest over four years, beginning with 25% vesting one year after the date of grant, then pro-rata vesting quarterly thereafter based on continued service. We believe that stock options structured in this manner encourage our executive officers to focus on increasing stockholder value and stock price appreciation over the long term and limit unnecessary risk taking behavior, while promoting retention.

        In 2016, we (i) ended the year with cash, cash equivalents and marketable securities of $189.8 million and (ii) accomplished the following significant clinical and operational milestones during the year:

    Kolltan Pharmaceuticals acquisition completed:  In late November, we completed the acquisition of Kolltan Pharmaceuticals, Inc., adding a unique platform of antibodies targeting receptor tyrosine kinases (RTKs) to our pipeline. Clinical and preclinical data suggest these drug candidates can help overcome tumor resistance mechanisms associated with current tyrosine kinase inhibitors and seen in patients who have failed other cancer therapies.

    Considerable progress in METRIC enrollment:  Enrollment in the Phase 2b randomized study (METRIC) of glembatumumab vedotin in patients with metastatic triple negative breast cancers that overexpress gpNMB has accelerated consistently over the last several months across the United States, Canada, Australia and the European Union. Assuming the current rate of enrollment continues, we expect enrollment will be completed by the end of September 2017.

    Third arm added to glembatumumab vedotin Phase 2 study in metastatic melanoma:  Enrollment has initiated in a glembatumumab vedotin plus checkpoint inhibitor (Opdivo® or Keytruda®) arm in patients who failed prior checkpoint therapy. Enrollment continued in the glembatumumab vedotin and varlilumab arm, with data from this portion of the study expected in the fall of 2017. Positive data from the single-agent arm of this study in patients who had previously progressed on checkpoint therapy were presented at the European Society for Medical Oncology (ESMO) Congress in October 2016.

    Continued progress in Phase 2 varlilumab/Opdivo® study:  The Phase 2 study of varlilumab and Opdivo continues to enroll patients across multiple indications (colorectal cancer, ovarian cancer, head and neck squamous cell carcinoma, renal cell carcinoma and glioblastoma). We anticipate that data from the Phase 1 study of varlilumab and Opdivo will be presented mid-year 2017. We plan to complete enrollment across all cohorts in the Phase 2 portion of the study in the first quarter of 2018 and will work with Bristol-Myers Squibb to present data from the study at a future medical meeting.

    Enrollment ongoing in Phase 1 study of CDX-014:  The study in advanced renal cell carcinoma (clear cell and papillary) is designed to determine the maximum tolerated dose and to recommend a dose level for further study. We expect the Phase 1 dose-escalation portion of the study will complete enrollment by year-end 2017.

Independent Compensation Consultants

        The Compensation Committee believes that independent advice is important in developing Celldex's director and executive compensation programs and in 2016, 2015 and 2014 engaged Radford as its independent compensation consultant. In 2016, Radford focused on both executive and director compensation. In 2015, Radford focused on director compensation and in 2014, Radford focused on executive compensation. In 2015, Radford also provided advisory services in connection with the amendment and restatement of our 2008 Stock Option and Incentive Plan, including an increase in the number of shares reserved for issuance under the Plan. Radford reports directly to the Committee and


provides guidance on trends in executive and non-employee director compensation, the development of specific executive compensation programs, the composition of the Company's compensation peer group and other matters as directed by the Committee. The Company also participated in various Radford surveys in 2016, 2015 and 2014. During 2016, 2015 and 2014, the Company paid Radford approximately $67,700, $35,300 and $52,300, respectively, in consulting fees directly related to these services. In 2016, 2015 and 2014, Radford did not provide any other services to Celldex.

Data Used to Make Compensation Determinations

        In making decisions regarding the compensation of our executive officers, the Compensation Committee generally considers compensation and survey data for similarly situated executives at a comparison group of companies it considers our peer group. These comparison data are primarily used to gauge the reasonableness and competitiveness of executive compensation decisions.

        We draw upon a pool of talent that is highly sought after by large and established pharmaceutical and biotechnology companies as well as by other development-stage life science companies, both within and outside our geographic areas. We believe that the compensation practices of our industry in general and of our select peer group in particular provide useful information to help us establish compensation practices that allow us to attract, retain, and motivate a highly talented executive team. We believe we must offer a compensation package to all of our officers and our other employees that is competitive with our peer group, as well as larger pharmaceutical and biotechnology companies from whom we frequently recruit. In addition, the comparator companies should be aligned with our current stage of development and have similar short and long-term growth objectives. In 2016, the Compensation Committee set the target level of total executive compensation, as well as the key elements of compensation, at the 50th percentile of our peer group, but then adjusted each of the elements based on an individual's performance and contribution to our strategic objectives. The Committee may need to adjust these levels in the future to attract or retain specific individuals.

        We review the levels of cash, equity and total compensation for all comparable officers in our peer group relative to the elements of compensation paid to our officers. In considering how these data relate to our existing compensation structure, we take into account our size, stage of development, performance and geographic location as compared to these peer companies, as well as what we know about the comparable scope of responsibilities of our officers versus those of comparable executives at such peer group companies. With the assistance of our compensation consultant, Radford, we used two primary market frames of reference (which we refer to as the "market") against which to compare our total executive compensation practices and levels and inform our decisions regarding compensation of our officers as follows:

    Select Peer Group—A select group of national biotechnology companies at a similar stage of development as our company with similar headcount, R&D expense, market capitalization and in most cases, similar therapeutic targets, and

    Radford Global Life Sciences Survey—A national survey of executive compensation levels and practices that covers approximately sixty executive positions in over 600 multinational life sciences organizations.

        We do not apply a specific weighting to either data source when making compensation comparisons. Instead, we develop competitive market guidelines using these data sources.

        We review our peer group each year to ensure continued relevance as we grow and develop, and the Compensation Committee approves our peer group prior to its adoption. The select peer group as


of May 2016 was analyzed and used to inform our decisions affecting executive compensation based on 2016 performance consisted of the following companies:

Achillion Pharmaceuticals, Inc.MacroGenics, Inc.
Agenus Inc.Merrimack Pharmaceuticals, Inc.
bluebird bio, Inc.NewLink Genetics Corporation
Clovis Oncology, Inc.OncoMed Pharmaceuticals, Inc.
Epizyme, Inc.Progenics Pharmaceuticals, Inc.
Exelixis, Inc.PTC Therapeutics, Inc.
ImmunoGen, Inc.Puma Biotechnology, Inc.
Infinity Pharmaceuticals, Inc.Sangamo BioSciences, Inc.
Inovio Pharmaceuticals, Inc.Xencor, Inc.
INSYS Therapeutics, Inc.ZIOPHARM Oncology, Inc.
Keryx Biopharmaceuticals, Inc.

        This peer group consisted of public companies in the biopharmaceutical industry with product candidates generally in late-stage development, with similar employee headcount (average of 184), R&D expense less than $282 million (average of $93 million) and market capitalization in the range of $283 million to $1.9 billion (average of $727 million). We believe that, as of May 2016, this list was representative of the companies with whom we generally compete for talent.

Administration and Objectives of Our Executive Compensation Program

        The Compensation Committee of the Board of Directors, which is comprised ofcomprises independent, non-employee directors, is responsible for establishing and administering the policies governing the compensation of AVANT’sour employees, including salary, bonus and stock option grants. The policy of the Compensation Committee is to compensate our employees with competitive salaries based on their level of experience and job performance. All permanent employees, including executive officers, are eligible for annual bonus awards based on achievement of AVANTsour strategic corporate goals and participation in our stock option program. The bonus awards and stock option grants are made in accordance with the AVANT Performance Incentive Plan and 1999our 2008 Stock Option and Incentive Plan.Plan, as amended (the "2008 Plan"). The Compensation Committee is also responsible for the administration of our 2004 Employee Stock Purchase Plan, as amended (the "2004 Plan"), in which employees participate on a voluntary basis.

        Our compensation committeeCompensation Committee has designed our overall executive compensation program to achieve the following objectives:

  • attract and retain talented and experienced executives executives;

    motivate and reward executives whose knowledge, skills and performance are critical to our successsuccess;

  • provide a competitive compensation package that aligns the interests of our executive officers and stockholders by including a significant variable component which is weighted heavily towards performance-based rewards, based upon achievement of pre-determined goalspredetermined goals;

  • ensure fairness among the executive management team by recognizing the contributions each executive makes to our success success;

    foster a shared commitment among executives by aligning AVANT’sour and their individual goals,goals; and

    compensate our executives to manage our business to meet our near-term and long-term objectives
  • objectives.

        We use a mix of short-term compensation (base salaries and cash incentive bonuses) and long-term compensation (equity incentive compensation) to provide a total compensation structure that is


designed to achieve these objectives. We determine the percentage mix of compensation structures that we think is appropriate for each of our executive officers. In general, the Compensation Committee believes that a substantial percentage of the compensation of our executive officers should be performance based. The Compensation Committee uses its judgment, and experience and the recommendations of the Chief Executive Officerchief executive officer (except for herhis own compensation) to determine the appropriate mix of compensation for each individual.

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        In determining whether to adjust the compensation of any one of our executive officers, including our Named Executive Officers, we annually take into account the changes, if any, in the following:

  • market compensation levelslevels;

  • the contributions made by each executive officerofficer;

  • the performance of each executive officerofficer;

  • the increases or decreases in responsibilities and roles of each executive officerofficer;

  • the business needs forof the Company with respect to each executive officerofficer;

  • the relevance of each executive officer’sofficer's experience to other potential employersemployers; and

  • the readiness of each executive officer to assume a more significant role within the organization
  • organization.

        In addition, with respect to new executive officers, we take into account their prior base salary and annual cash incentives, their expected contribution and our business needs. We believe that our executive officers should be fairly compensated each year relative to market pay levels within our industry and that there should also be internal equity among our executive officers.industry.

Executive Compensation Components

        In order to both attract and retain experienced and qualified executives to manage AVANT,us, the Compensation Committee’sCommittee's policy on executive compensation is to (i) pay salaries which are competitive with the salaries of executives in comparable positions in the biotechnology industry, and (ii) allow for additional incentive-based compensation upon achievement of goals under the Performance Incentive Plan and through the appreciationpayment of annual cash bonuses and the grant of stock-based incentive awards. This policy is designed to have a significant portion of each executive’sexecutive's total compensation be tied to AVANT’sour progress in order to incentivize the executive to fully dedicate himself or herself to achievement of corporate goals, and to align the executive’sexecutive's interest with those of our stockholders through equity incentive compensation.

        Our executive compensation program is primarily composed of base salary, annual incentive cash compensation payable on an annual basis and equity compensation. In addition, we provide our executives with benefits that are generally available to our salaried employees, including medical, dental, group life and accidental death and dismemberment insurance, short- and long-term disability coverage and our 401(k) plan. Within the context of the overall objectives of our compensation programs, we determined the specific amounts of compensation to be paid to each of our executives in 20072016 based on a number of factors including:

  • our understanding of the amount of compensation generally paid by similarly situated companies to their executives with similar roles and responsibilitiesresponsibilities;

  • the roles and responsibilities of our executivesexecutives;

  • the individual experience and skills of, and expected contributions from, our executives executives;

    the amounts of compensation being paid to our other executivesexecutives; and

  • our executives’executives' historical compensation at AVANT
  • compensation.

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        We discuss each of the primary elements of our executive compensation in detail below. While we have identified particular compensation objectives that each element of executive compensation serves, our compensation programs complement each other and collectively serve all of our executive compensation objectives described above. Accordingly, whether or not specifically mentioned below, we believe that, as a part of our overall executive compensation, each element to a greater or lesser extent serves each of our objectives.

Base salarySalary.

        Each executive officer (except the Chief Executive Officerchief executive officer whose performance is reviewed by the Compensation Committee) has an annual performance review with the Chief Executive Officerchief executive officer who makes recommendations on salary increases, promotions and stock option grants to the Compensation Committee. We have historically established base salaries for each of our executives based on many factors, including average salary increases expected in the biotechnology industry in the Boston, Massachusetts, area,New Haven, Connecticut and central New Jersey areas, competition in the marketplace to hire and retain executives, experiences of the members of our Board of Directorsmembers and leadership team with respect to salaries and compensation of executives in similarly situated companies in our industry and other similar industries, as well as additional factors which we believe enablesenable us to hire and retain our leadership team in an extremely competitive environment. Our compensation committeeCompensation Committee annually reviews salary ranges and individual salaries for our executive officers.

The Compensation Committee increased the annual base salaries paidsalary for Mr. Marucci, Mr. Catlin, Dr. Davis and Dr. Keler by 2.0% to 3.5% in mid-2016, depending on the position. Ms. Crowley's annual base salary increased 6.0% upon her promotion to Senior Vice President and Chief Product Development Officer in August 2016. For 2015, the Compensation Committee increased annual base salary for our Named Executive Officers are set forth below inby 3.1% to 6.5%. For 2014, the summary compensation table. For the fiscal year ended December 31, 2007, theCompensation Committee increased annual base salaries ofsalary by 3.0% to 6.5% for our President and ChiefNamed Executive Officer, Chief Operating Officer, Chief Financial Officer, Senior Vice President of Research and Development, Vice President of Research and Vice President, Medical and Regulatory Affairs were $440,000, $285,000, $251,121, $161,046, $201,899 and $254,719, respectively. These salaries represent an average increase of approximately 5.5% over the 2006 fiscal year base salaries of these executive officers, excluding the Senior Vice President of Research and Development who resigned from AVANT effective July 31, 2007. The salaries in 2007 were either at or slightly above the fiftieth percentile of the salaries paid to persons in comparable positions using an independently prepared 2006 employee compensation survey of over 400 biotechnology companies. We believe that the base salaries paid to our executive officers during our fiscal year ended December 31, 2007 achieve our executive compensation objectives and are comparable to similarly situated companies.Officers.

Performance Incentive PlanAnnual Performance-Based Cash Bonus.

        We have designed our performance plan programannual cash bonuses to reward our executive officers upon the achievement of certain annual revenue, cash flow, research, clinical development, regulatoryfor their individual performance and business developmenttheir actual performance and contributions to our corporate goals for each year, as approved in advance by our Compensation Committee and the Board of Directors. The bonus award is based on achievement of AVANTs corporate goals which are set at the beginning of each fiscal year and measured against performance at the end of the year by AVANT in accordance with the Performance Incentive Plan. For 2007, the corporate goals were applicable to all employees, including the executive officers and included (i) overall strategic goals and (ii) goals applicable to our therapeutic programs.

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The corporate goals were allocated between specific product and financial performance targets. Achievement of our corporate goals was, in 2016, the primary factor considered by our Compensation Committee in determining the annual bonuses for our executive officers. However, the Compensation Committee retains discretion to adjust any individual bonus based on assessment of such individual's performance. Our performanceperformance-based bonus plan emphasizes pay-for-performance and is intendedthe contributions of each of our executive officers to closely align executive compensation withthe achievement of certain operating results and an increase in stockholder value. Theour corporate goals.

        At the beginning of each calendar year, the Compensation Committee establishes annual corporate performance goals and target bonuses. In 2016 based on Radford's recommendation, the Compensation Committee established target bonuses for each of our Named Executive Officers as follows: 60% of base salary for Mr. Marucci and 40% of base salary for Dr. Keler, Mr. Catlin and Dr. Davis. Ms. Crowley became a Named Executive Officer in August 2016 and her target bonus of 35% is based on her employment agreement. Corporate goals are proposed by management, reviewed and approved by the Compensation Committee and also approved by the Board of Directors communicateon an annual basis. The Compensation Committee considers and assigns a relative weight to appropriately focus efforts on corporate goals that are intended to enhance shareholder value.

        The Compensation Committee reviewed the 2016 corporate goals at meetings held in April, June and September 2016 to gauge our levels of achievement and to assess whether the corporate goals approved earlier in the year remained relevant and complete. In December 2016 and February 2017, prior to approving 2016 incentive bonuses, the Compensation Committee evaluated our 2016


performance by assessing if, and the extent to which, we achieved or failed to achieve the corporate goals approved by the Board of Directors for 2016. The Compensation Committee considered the progress in our clinical programs, including our glembatumumab vedotin and varlilumab programs, and our corporate development activities. Based primarily on the discontinuation of our Phase 3 study of Rintega® in patients with newly diagnosed EGFRvIII-positive glioblastoma in March 2016 and our inability to raise sufficient financing, other than through our ATM facility with Cantor, to provide cash runway into 2019, the Compensation Committee determined that we met 80% of our 2016 corporate goals for pipeline development and business and financial operations. Our corporate goals for 2016 and the level at which the Compensation Committee determined they were achieved are as follows:

2016 Corporate Goal Relative
Weight
 2016
Achievement
 

Pipeline Development:

  50  80%

Rintega (Rindopepimut) Development Activities

       

Deliver savings of >$45M in 2016 associated with wind down activities

       

Support continued access to Rintega via compassionate use for appropriate patients as long as benefitting

       

Glembatumumab Vedotin (CDX-011) Development Activities

       

Activate ~50 European sites to supplement METRIC enrollment

       

Deliver top-line primary study results in melanoma (ORR, duration of response and safety) and progress melanoma development strategy

       

Develop commercial strategy for key indications, markets and potential for partnerships

       

Varlilumab (CDX-1127) Development Activities

       

Complete combination Phase 1 dosing studies to evaluate preliminary safety, select Phase 2 dose and initiate Phase 2 enrollment of combination studies to explore activity and further evaluate safety

       

Develop commercial strategy for key indications, markets and potential for partnerships

       

CDX-1401/CDX-301 Development Activities

       

Initiate company sponsored study in combination with a checkpoint inhibitor

       

Support expanded clinical development through external collaborations

       

CDX-014 Development Activities

       

Complete site activation and initiate Phase 1 study

       

CDX-1140 Development Activities

       

Manage preclinical development of agonist CD40 mAb towards IND filing in 2017

       

Business and Financial Operations:

  50  80%

Provide sufficient cash through various mechanisms to achieve our corporate goals and extend our runway through 2018

       

Complete a substantial collaboration or licensing transaction with respect to pipeline assets in 2016, if appropriate and acceptable

       

Totals:

  100  80%

        Prior to the Compensation Committee's December 2016 and February 2017 meetings, Mr. Marucci reviewed in detail the performance of each executive officer, excluding himself, and considered such individual's contributions to our success in 2016. Mr. Marucci's bonus criteriarecommendations were based on such individual performance assessments and the fact that the Company achieved 80% of its predetermined corporate goals in 2016 and each employee, including the executive officers, contributed to all employees, includingour success in achieving the 2016 corporate goals.


        The Compensation Committee discussed Mr. Marucci's recommendations for the Named Executive Officers at the beginningand reviewed Mr. Marucci's performance for fiscal 2016. Based on Mr. Marucci's recommendations for each of the fiscal year. TheNamed Executive Officers, the Compensation Committee's review of Mr. Marucci's performance and the Compensation Committee's determination that 80% achievement of the corporate goals and bonus criteriafor 2016, the Compensation Committee determined that the annual cash incentives approved for each Named Executive Officer (including Mr. Marucci) should be set at 75.7% to 83.5% of the targets established by the compensation committee under the Performance Incentive Plan are designed to require significant effort and operational successfor each Named Executive Officer, depending on the part of our executivesposition.

        The Compensation Committee determined that annual incentive bonuses paid to the Named Executive Officers for 2016, were fair, reasonable and AVANT for achievement. We measure such bonus criteria against actual operating resultsappropriate based on an annual basis.the factors described above.

Equity Compensation.

        We also use stock options and equity-based incentive programs to attract, retain, motivate and reward our executive officers. Through our equity-based grants, we seek to align the interests of our executive officers with our stockholders, reward and motivate both near-term and long-term executive performance and provide an incentive for retention. Our decisions regarding the amount and type of equity incentive compensation and relative weighting of these awards among total executive compensation have been based on our understanding of market practices of similarly situated companies and our negotiations with our executives in connection with their initial employment or promotion.

        Our recent practice has beenWe have adopted an equity grant policy that formalizes how we grant equity awards by setting a regular schedule for granting equity awards in connection with the hiring or promotion of any of our employees, granting annual equity awards and granting equity awards to non-employee directors. Such policy also outlines grant equity-basedapproval requirements and specifies the vesting schedule and exercise prices for restricted stock units and stock option awards. We believe that this policy will mitigate the risk that issues or concerns would be raised in the future regarding the timing of grants of equity awards to our executive officers, if any at all, on an annual basis.directors and employees.

        All such grants to our Named Executive Officers are subject to prior approval by the Compensation Committee at a regularly scheduled meeting during the year. The date of grant and the fair market value of the award are based upon the date of the Compensation Committee meeting approving such grant. When granting stock options,equity-based awards, the Compensation Committee considers a number of factors in determining the amount of equity incentive awards, if any, to grant to our executives, including:

  • the existing levels of stock ownership among the executive officers relative to each other and to our employees as a whole whole;

    previous grants of stock options to such executive officersofficers;



  • vesting schedules of previously granted optionsoptions;



  • the performance of the executives and their contributions to our overall performance

  • performance;

    an outside survey of stock option grants and restricted common stock awards in the biotechnology industry industry;

    an internally prepared survey of similarly situated biotechnology companies’companies' proxy statementsstatements;



  • personal knowledge of the Compensation Committee members regarding executive stock options and restricted common stock awards at comparable companiescompanies;



  • the financial statement impact of stock option awards on our results of operationsoperations; and



  • the amount and percentage of our total equity on a diluted basis held by our executives

  • executives.

-18-



        Equity compensation awards to our Named Executive Officers primarily consist of stock option awards. Stock option awards provide our executive officers with the right to purchase shares of our common stock at a fixed exercise price typically for a period of up to ten years, subject to continued employment with AVANT.us. Stock options are earned on the basis of continued service to us and generally vest over four years, beginning with 25% vesting one year after the date of grant, then pro-rata vesting annuallyquarterly thereafter.

All historical option grants were made at what our Compensation Committee and Board of Directors determined to be the fair market value of our shares of our common stock on the respective grant dates. In January 2007, we granted

        On June 8, 2016, the Compensation Committee awarded stock options to our President and Chief Executive Officer, Chief Operating Officer, Chief Financial Officer, Senior Vice President of Research and Development, Vice President of Research and Vice President, Medical and Regulatory Affairsall qualified employees, including stock options to purchase 50,000, 40,000, 25,000, 25,000, 12,000475,000 shares, 162,000 shares, 157,000 shares, 135,000 shares and 15,00081,000 shares respectively. In September 2005, November 2004of our common stock to each of Messrs. Marucci, Keler, Davis and September 2003, AVANT also awarded Restricted Stock Units to Dr. RyanCatlin and recorded non-cash deferred compensation amounting to $270,000, $832,000 and $1,104,000,Ms. Crowley, respectively.

        On September 21, 2006, AVANT’sMarch 1, 2017, the Board of Directors modified these Restricted Stock Unitsapproved an amendment to the 2008 Plan, subject to approval at this Annual Meeting by our stockholders, to increase the number of shares reserved for issuance thereunder by 5,650,000 to 20,000,000 shares.

        The Board of Directors believes that the approval of the amendment to the 2008 Plan to increase in the number of shares reserved for issuance thereunder is essential to our continued success. In particular, the Board of Directors believes that our employees are our most valuable assets and that the awards permitted under the 2008 Plan are vital to our ability to attract and retain outstanding and highly skilled individuals in the extremely competitive labor markets in which we operate. Such awards also are important to our ability to motivate our employees to achieve our goals. The proposed increase in the number of shares authorized for issuance under the 2008 Plan is intended to provide that they vest in their entirety upon the earlier of the sale of AVANT or Dr. Ryan’s retirement at or after age 65. We recognize stock-based compensation expense under SFAS 123R using the fair-value based methodsufficient shares to fund anticipated equity awards for all awards granted on or after the date of our adoptionnew and these values have since been reflected in our consolidated financial statements. Accordingly, the extent and value of our stock-based awards to our executive officers and otherexisting employees and directors have a direct effect on the calculation of our operating profit margin, a principal component of variable compensation under our performance plan.independent contractors for up to three years.

     In April 2007, we adopted an equity grant policy for 2007 that formalizes how we grant equity awards by setting a regular schedule for grants, outlining grant approval requirements and specifying how awards are priced. We believe that this policy will enable us to avoid any option backdating issues or concerns that our awards were timed to precede or follow our release or withholding of material non-public information.

Other Benefits

        We believe that establishing competitive benefit packages for our employees is an important factor in attracting and retaining highly qualified personnel. Executive officers are eligible to participate in all of our employee benefit plans, such as medical, dental, group life and accidental death and dismemberment insurance, short- and long-term disability coverage and our 401(k) plan, in each case on the same basis as other employees. We provide a matching contribution under our 401(k) plan.

-19-Employment Agreements and Post-Termination Compensation and Benefits


        We depend greatly on the intellectual capabilities and experience of our key executives. Our success is dependent on our ability to attract and retain highly skilled executives with significant experience in the biotechnology industry, particularly as we expand our activities in clinical trials, the regulatory approval process and sales and manufacturing. Therefore we enter into employment agreements with each of our Named Executive Officers.

        In general, each employment arrangement provides for cash severance, 100% acceleration of any unvested options, restricted stock and/or other equity awards and continuation of certain employee benefits in the event that an executive's employment is terminated without cause or is terminated by the executive for good reason within a one year period immediately following a change of control. The cash severance consists of a single lump sum payment equal to (i) twenty-four (24) times the executive's highest monthly base compensation paid hereunder during the preceding twenty-four month period, plus (ii) 150% (200%, in the case of Mr. Marucci) of the highest one-year annual bonus actually received by the executive during the preceding two full fiscal years prior to the date of termination. We use a "double trigger" with respect to benefits that are to be provided in connection with a change of control. A change of control does not itself trigger benefits; rather, benefits are paid only if the


employment of the executive is terminated by us other than for cause, death or disability or by the executive for good reason during the one year period immediately following the change of control. We believe a "double trigger" benefit maximizes shareholder value because it prevents a windfall to executives in the event of a change of control in which the executive retains significant responsibility as defined in his or her individual agreement, while still providing our executives appropriate incentives to cooperate in negotiating any change of control that may put their jobs at risk.

        In addition to the benefits that only accrue in connection with a change of control, our agreements with the Named Executive Officers provide for cash severance, 25% acceleration of unvested options, restricted stock and/or other equity awards and continuation of certain employee benefits if we terminate their employment with us without cause or they terminate their employment with us for good reason, as such terms are defined in the applicable agreement with the executive officer. The cash severance consists of a lump sum cash payment equal to 100% (200% in the case of Mr. Marucci) of the executive's then existing base salary. A further discussion of the terms and projected payments under each of these agreements is set forth below under the headingPotential Payments upon Termination of Employment or Change in Control.

Committee Consideration of the Company's 2016 Shareholder Advisory Vote on Executive Compensation

        At our 2016 Annual Meeting of Shareholders, approximately 96% of the shares voted at the meeting approved, on an advisory basis, the compensation of the Named Executive Officers. Given that a majority of the shares voted approved the 'say on pay' advisory proposal, the Committee did not implement specific changes and continued with its performance-based compensation philosophy and its balanced approach to various components of its compensation program. However, the Compensation Committee does monitor the results of the annual advisory 'say-on-pay' proposal and refers to such results as one of many factors considered in connection with the discharge of its responsibilities, although the Committee does not assign a quantitative weighting to any such factors.

        Our Board of Directors has determined that an advisory vote should be conducted on an annual basis and has recommended that our stockholders indicate their preference for an annual advisory vote in Proposal No. 7.



Summary Compensation Table

        The following summary compensation table reflects certain information concerning compensation for services in all capacities awarded to, earned by or paid during the years ended December 31, 20072016, 2015 and 20062014 to each person who served as AVANT's (on a stand-alone basis prior to the Merger)our Chief Executive Officer and Chief Financial Officer at any time during the year ended December 31, 2016 and the three other most highly compensated executive officers, employed byother than the CompanyChief Executive Officer and Chief Financial Officer, who were serving as executive officers as of December 31, 2007 and up to two additional executive officers who would have been among the most highly compensated executive officers had they been employed as of December 31, 20072016 (collectively, the “Named"Named Executive Officers”Officers").

Name and Principal PositionYearsSalaryBonusStockOptionNon-Equity ChangeinAll OtherTotal
  ($)($)(1)AwardsAwards ($)(3)Incentive Plan PensionValueCompensation($)
     ($)(2)   Compensation and Nonqualified($)(4)  
         ($)Deferred   
          Compensation   
              Earnings ($)     
Una S. Ryan, Ph.D.(5)2007  440,000123,200----12,266 ------2,700454,966
Presidential and Chief Executive Officer2006 415,00073,0401,225,00026,250------2,7001,741,990
          
M. Timothy Cooke, Ph.D.(6)2007 285,00049,875----117,524------420402,944
Chief Operating Officer2006 262,50028,875----107,199------420398,994
          
Avery W. Catlin2007 251,12135,818----15,615------2,700269,436
Senior Vice President and Chief Financial Officer  2006 241,46221,249----12,008------2,680277,399
          
Ronald W. Ellis(7)2007161,046-------78,137------350239,533
Senior Vice President, Research and Development  2006 224,51922,000----67,534------550314,603
          
Henry C. Marsh, Jr., Ph.D.2007 201,89928,266----7,503------2,504211,906
Vice President, Research2006 194,13417,084----7,129------2,408220,755
          
Taha Keilani, M.D.(8)2007 254,71935,000----22,716------2,520279,955
Vice President, medical and Regulatory Affairs  2006 244,92321,553 18,766------2,520287,762

Name and Principal Position
 Years Salary
($)
 Bonus
($)(1)
 Stock
Awards
($)
 Option
Awards
($)(2)
 Non-Equity
Incentive
Plan
Compensation
($)
 Change in
Pension
Value and
Nonqualified
Deferred
Compensation
Earnings
($)
 All Other
Compensation
($)(3)
 Total
($)
 
Anthony S. Marucci  2016  577,361  282,086    1,496,440      14,308  2,370,195 

President and Chief

  2015  559,400  302,924    4,371,528      39,874  5,273,726 

Executive Officer

  2014  520,879  293,234    2,431,856      64,937  3,310,906 

Avery W. Catlin

 

 

2016

 

 

337,235

 

 

105,000

 

 


 

 

425,304

 

 


 

 


 

 

7,132

 

 

874,671

 

Senior Vice President and

  2015  339,457  130,000    1,436,359      6,024  1,911,840 

Chief Financial Officer

  2014  317,017  102,097    799,038      5,717  1,223,869 

Thomas Davis, M.D. 

 

 

2016

 

 

438,057

 

 

134,000

 

 


 

 

494,613

 

 


 

 


 

 

9,361

 

 

1,076,031

 

Executive Vice President

  2015  434,421  165,000    1,818,868      9,297  2,427,586 

and Chief Medical Officer

  2014  407,453  148,960    1,011,826      8,749  1,576,988 

Tibor Keler., Ph.D. 

 

 

2016

 

 

414,445

 

 

134,324

 

 


 

 

510,365

 

 


 

 


 

 

3,937

 

 

1,063,071

 

Executive Vice President

  2015  409,996  159,000    1,818,868      3,800  2,391,664 

and Chief Scientific Officer

  2014  384,517  158,500    1,011,826      3,763  1,558,606 

Elizabeth Crowley(4)

 

 

2016

 

 

321,970

 

 

97,000

 

 


 

 

255,182

 

 


 

 


 

 

4,233

 

 

678,385

 

Senior Vice President and

                            

Chief Product Development

                            

Officer

                            

(1)
The amounts in the Bonus column include annual bonus amounts earned by each of our Named Executive Officers in 20072016, 2015 and 2006 under AVANT’s Performance Incentive Plan.

2014.

(2) This amount relates to the modification during 2006 of prior awards. See “Compensation Discussion and Analysis—Executive Compensation Components—Equity Compensation.” The amount represents non-cash deferred compensation recognized under SFAS 123R as a result of the modification in September 2006 of Restricted Stock Unit awards made to Dr. Ryan in September 2003, November 2004 and September 2005 to provide that they vest in their entirety upon the earlier of the sale of AVANT or Dr. Ryan’s retirement at or after age 65. Insofar as Dr. Ryan reached age 65 in 2006, under SFAS 123R the entire unamortized fair value of the modified awards ($1,225,000) had to be recognized in 2006 even though Dr. Ryan continues to be an executive officer of AVANT. The Restricted Stock Unit awards made to Dr. Ryan were settled for stock on a one-for-one basis upon the consummation of the Merger on March 7, 2008.

(3)

The amounts in the Option Awards column reflect the dollar amounts recognized for financial statement purposes for the aggregate grant date fair value in accordance with accounting principles generally accepted in the United States of America (U.S. GAAP) of stock option awards made in fiscal years ended December 31, 20072016, 2015 and 2006, in accordance with FAS 123(R), (excluding the impact of estimated forfeitures related to service-based vesting conditions),2014 for annual awards pursuant to the AVANT 1999 Stock Option and Incentive Plan, and thus may include amounts attributable2008 Plan. For a discussion regarding the valuation of our stock option awards for financial statement reporting purposes, please refer to awards granted during and before 2007 and 2006. Assumptions madeNote 2 in the calculation of these amounts are included in Note 5Notes to our Consolidatedthe Financial Statements contained in our annual reportAnnual Report on Form 10-K for the year ended December 31, 2007.2016. These numbersamounts do not reflectrepresent the 1-for-12 reverseactual amounts paid to the Named Executive Officers or the actual value that may be realized by the Named Executive Officers upon exercise of such stock split effected on March 7, 2008.

-20-


(4) options.

(3)
The amounts listed in the All Other Compensation column includes AVANTsour matching contribution to the 401(k) Savings Plan of each Named Executive Officer and premiums paid for life insurance under AVANT’sour nondiscriminatory group plan for each Named Executive Officer.

(5) Dr. Ryan resigned from her position as In addition, Mr. Marucci's compensation includes (i) the annual premium of $2,550 in 2016, 2015 and 2014 for a $1,000,000 term life insurance policy, (ii) $3,123, $3,948 and $4,747 for the personal use of a Company car in 2016, 2015 and 2014, and (iii) tuition reimbursement of $24,634 and $49,266 in 2015 and 2014 related to an executive master of healthcare leadership program.

(4)
On August 10, 2016, Elizabeth Crowley was promoted to Senior Vice President and Chief Executive Officer effective May 7, 2008.

(6) Dr. Cooke joined AVANT on August 1, 2004. Dr. Cooke resigned from AVANT effective February 11, 2008.

(7) Dr. Ellis joined AVANT on January 23, 2006. Dr. Ellis resigned from AVANT effective JulyProduct Development Officer. The amounts included above are for the full year ended December 31, 2007.

2016.

(8) Dr. Keilani joined AVANT in June 2004. Dr. Keilani resigned from AVANT effective April 17, 2008.


Grants of Plan-Based Awards

        The following table provides information on stock options restrictedand stock units and performance stock unitsawards granted in 2007 and 20062016 to each of AVANT’s (on a stand-alone basis prior to the Merger)our Named Executive Officers.

 
  
  
  
  
  
 All Other
Option
Awards:
Number of
Securities
Underlying
Options
(#)
  
  
 
 
  
 Estimated Future
Payouts Under
Equity Incentive Plan Awards
 All Other
Stock
Awards:
Number of
Shares or
Units
(#)
  
 Grant Date
Fair Value of
Stock and
Option
Awards
($)(2)
 
 
  
 Exercise or
Base Price of
Option
Awards
($/Sh)(1)
 
Name
 Grant
Date
 Threshold
(#)
 Target
(#)
 Maximum
(#)
 

Anthony S. Marucci

  6/8/16              475,000  4.72  1,496,440 

Avery W. Catlin

  6/8/16              135,000  4.72  425,304 

Thomas Davis, M.D. 

  6/8/16              157,000  4.72  494,613 

Tibor Keler, Ph.D. 

  6/8/16              162,000  4.72  510,365 

Elizabeth Crowley

  6/8/16              81,000  4.72  255,182 

(1)
The numbers below do notexercise prices reflect the 1-for-12 reverse stock split effected on March 7, 2008.

GRANTS OF PLAN-BASED AWARDS
 
Estimated Future Payouts Under Equity Incentive Plan Awards
 
 Grant Date Threshold Target Maximum All Other All Other Exercise or Base Market Price Grant Date
  (#)  (#) (#) Stock Option Price of Option on Date of Fair Value
     Awards: Awards: Awards ($/Sh)(1) Grant(#)(1)of Stock
     Number of Number of   and
Name     Shares or Securities   Option
      Units (#) Underlying   Awards
                Options (#)         ($)(2)
Una S. Ryan, Ph.D.01/05/07 50,000    1.361.3549,195
 01/06/06        
 
M. Timothy Cooke, Ph.D.01/05/07 40,000   1.36 1.3539,356
 01/06/06 100,000   2.042.08152,740
 
Avery W. Catlin01/05/07 25,000   1.361.3524,598
 01/06/06 25,000   2.042.0838,185
 
Ronald W. Ellis, Ph.D. 01/05/07 25,000   1.361.3524,598
 01/23/06 200,000   1.931.94288,500
 
Henry C. Marsh, Jr., Ph.D.01/05/07 12,000   1.361.3511,807
 01/06/06 12,000   2.042.0818,329
 
Taha Keilani, M.D.01/05/07 15,000   1.361.3514,759
 01/06/06 50,000   2.042.0876,360

(1) The exerciseclosing price of the option awards differs from the market price on the date of grant. The exercise price is determined based on the average of the high and low price of AVANT’sour common stock on the date of grant while the market price on the date of grant is the closing price of AVANT’s common stock on that date.



(2)
The grant date fair value isvalues are generally the amount AVANTwe would expense in itsour financial statements over the award’saward's service period, but does not include a reduction for forfeitures.


-21-



Outstanding Equity Awards at Fiscal Year-End

        The following table sets forth certain information regarding the stock option grants and stock awards to theour Named Executive Officers of AVANT (on a stand-alone basis prior to the Merger) at December 31, 2007. The numbers below do not reflect2016.

 
 Option Awards Stock Awards 
Name
 Number of
Securities
Underlying
Unexercised
Options (#)
Exercisable
 Number of
Securities
Underlying
Unexercised
Options (#)
Unexercisable
 Equity
Incentive
Plan
Awards:
Number of
Securities
Underlying
Unexercised
Unearned
Options (#)
 Option
Exercise
Price ($)
 Option
Expiration
Date
 Number of
Shares or
Units of
Stock
That
Have Not
Vested (#)
 Market
Value of
Shares or
Units of
Stock
That
Have Not
Vested ($)
 Equity
Incentive
Plan
Awards:
Number of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested (#)
 Equity
Incentive
Plan
Awards:
Market or
Payout
Value of
Unearned
Shares,
Units or
Other
Rights
That
Have Not
Vested (#)
 

Anthony S. Marucci(1)

    475,000     4.72  6/8/26             

Anthony S. Marucci(1)

  105,000  175,000     25.41  6/10/25             

Anthony S. Marucci(1)

  175,000  105,000     13.45  6/4/24             

Anthony S. Marucci(1)

  227,500  52,500     16.36  7/1/23             

Anthony S. Marucci

  280,000       5.69  9/12/22             

Anthony S. Marucci

  180,400       2.80  8/5/21             

Anthony S. Marucci

  164,000       4.50  1/21/20             

Anthony S. Marucci

  129,000       8.52  1/6/19             

Anthony S. Marucci

  254,243       8.16  3/7/18             

Avery W. Catlin(1)

    135,000     4.72  6/8/26             

Avery W. Catlin(1)

  34,500  57,500     25.41  6/10/25             

Avery W. Catlin(1)

  57,500  34,500     13.45  6/4/24             

Avery W. Catlin(1)

  73,125  16,875     16.36  7/1/23             

Avery W. Catlin

  90,000       5.69  9/12/22             

Avery W. Catlin

  35,000       2.80  8/5/21             

Avery W. Catlin

  67,153       4.50  1/21/20             

Avery W. Catlin

  11,000       8.52  1/6/19             

Thomas Davis, M.D.(1)

    157,000     4.72  6/8/26             

Thomas Davis, M.D.(1)

  43,687  72,813     25.41  6/10/25             

Thomas Davis, M.D.(1)

  72,812  43,688     13.45  6/4/24             

Thomas Davis, M.D.(1)

  93,437  21,563     16.36  7/1/23             

Thomas Davis, M.D. 

  115,000       5.69  9/12/22             

Thomas Davis, M.D. 

  104,500       2.80  8/5/21             

Thomas Davis, M.D. 

  95,000       4.50  1/21/20             

Thomas Davis, M.D. 

  76,400       8.52  1/6/19             

Thomas Davis, M.D. 

  148,825       8.16  3/7/18             

Tibor Keler, Ph.D.(1)

    162,000     4.72  6/8/26             

Tibor Keler, Ph.D.(1)

  43,687  72,813     25.41  6/10/25             

Tibor Keler, Ph.D.(1)

  72,812  43,688     13.45  6/4/24             

Tibor Keler, Ph.D.(1)

  93,437  21,563     16.36  7/1/23             

Tibor Keler, Ph.D. 

  115,000       5.69  9/12/22             

Tibor Keler, Ph.D. 

  99,000       2.80  8/5/21             

Tibor Keler, Ph.D. 

  90,000       4.50  1/21/20             

Tibor Keler, Ph.D. 

  72,250       8.52  1/6/19             

Tibor Keler, Ph.D. 

  254,243       8.16  3/7/18             

Elizabeth Crowley(1)

    81,000     4.72  6/8/26             

Elizabeth Crowley(1)

  28,125  46,875     25.41  6/10/25             

Elizabeth Crowley(1)

  19,375  11,625     13.45  6/4/24             

Elizabeth Crowley(1)

  24,375  5,625     16.36  7/1/23             

Elizabeth Crowley. 

  30,000       6.37  9/20/22             

Elizabeth Crowley. 

  15,000       2.80  8/5/21             

Elizabeth Crowley. 

  20,000       4.50  1/21/20             

(1)
25% of the 1-for-12 reverse stock split effected on March 7, 2008.

OUTSTANDING EQUITY AWARDS AT FISCAL YEAR-END – DECEMBER 31, 2007
 
Option Awards (1)
 
Name Number of SecuritiesNumber of SecuritiesEquity IncentiveOption ExerciseOption Expiration
 Underlying UnexercisedUnderlying UnexercisedPlan Awards:Price ($)Date
 Options (#)Options(#)Number of Securities
 ExercisableUnexercisableUnderlying Unexercised  
           Unearned Options (#)            
Una S. Ryan, Ph.D.100,000  $1.9702/09/2008
 100,000  $1.8801/04/2009
 250,000  $1.3105/06/2009
 165,000  $2.4101/06/2010
 80,000  $8.5311/17/2010
 100,000  $2.9911/08/2011
 100,000  $1.1401/02/2013
 ---50,000   
 
 
 895,00050,000   
 
M. Timothy Cooke, Ph.D.150,00050,000 $1.9308/02/2014
 12,000   $2.0801/03/2015
 25,000 75,000  $2.04 01/06/2016
 ---40,000 $1.3601/05/2017
 
 187,000165,000   
 
Avery W. Catlin200,000  $2.2801/05/2010
 25,000  $2.9911/08/2011
 5,000  $1.1401/02/2013
 12,000  $2.7701/02/2014
 12,000  $2.0801/03/2015
 6,25018,750 $2.0401/06/2016
 ---25,000 $1.3601/05/2017
 
 260,25043,750   
 
Henry C. Marsh, Jr., Ph.D.24,000  $1.9702/09/2008
 15,000  $1.6712/09/2008
 25,000  $2.4101/06/2010
 10,000  $8.5311/17/2010
 10,000  $2.9911/08/2011
 10,000  $1.1401/02/2013
 12,000  $2.7701/02/2014
 10,000  $2.0801/03/2015
 3,0009,000 $2.0401/06/2016
 ---12,000 $1.3601/15/2017
 
 119,00021,000   
 
Taha Keilani, M.D.50,000  $2.5906/07/2014
 12,000  $2.0801/03/2015
 12,50037,500 $2.0401/06/2016
 ---15,000 $1.3601/05/2017
 
 74,50052,500   

(1) All options are exercisable in 25% annual increments beginningvest on the first anniversary of the grant date of grant.

and the remainder vest quarterly (in equal amounts) over the subsequent 12 quarters.

-22-



Option Exercises and Stock Vested

        The following table sets forth certain information regarding the number of option exercises in fiscal 2016 and the number of shares of restricted stock issued under the AVANT 1999 Stock Option and Incentive2008 Plan that vested in fiscal 2007 and 20062016 and the corresponding amounts realized by our Named Executive Officers.

 
 Option Awards Stock Awards 
Name
 Number of Shares
Acquired on Exercise
(#)
 Value Realized
on Exercise
($)
 Number of Shares
Acquired on Vesting
(#)
 Value Realized
on Vesting
($)
 

Anthony S. Marucci

         

Avery W. Catlin

  47,847 $53,171(1)    

Thomas Davis, M.D. 

         

Tibor Keler, Ph.D. 

         

Elizabeth Crowley

         

(1)
Represents the aggregate dollar amount realized by the Named Executive OfficersOfficer upon exercise of AVANT (on a stand-alone basis priorthe options, calculated by determining the difference between the closing price on the date of exercise and the exercise price. These amounts do not correspond to the Merger).actual value received by the Named Executive Officers.


Employment Agreements

        The numbers below do not reflect the 1-for-12 reverse stock split effected on March 7, 2008.

    OPTION EXERCISES AND STOCK VESTED
    Option AwardsStock Awards
   Number ofValue RealizedNumber of SharesValue Realized on
   Shareson Exercise ($)Acquired onVesting ($)
    Acquired on Vesting (#) 
Name   Exercise (#)   
Una S. Ryan, Ph.D.------700,000$1,225,000
M. Timothy Cooke, Ph.D.------------
Avery W. Catlin------------
Henry C. Marsh, Jr., Ph.D.------------
Ronald W. Ellis, Ph.D.------------
Taha Keilani, M.D.------------

     In September 2005, November 2004terms and September 2003, AVANT awarded Restricted Stock Units to Dr. Ryan and recorded non-cash deferred compensation amounting to $270,000, $832,000 and $1,104,000, respectively. On September 21, 2006, AVANTs Board of Directors modified these Restricted Stock Units to provide that they vest in their entirety upon the earlierconditions of the saleemployment agreements of AVANT orMr. Marucci, Mr. Catlin, Dr. Ryan’s retirement at or after age 65.Davis and Dr. Ryan reached age 65 in December 2006.Keler are governed by written employment contracts which became effective on January 1, 2013. The Restricted Stock Unit awards made to Dr. Ryan were settled for stockterms and conditions of Ms. Crowley's employment agreement are governed by a written employment contract which became effective on a one-for-one basis upon the consummation of the Merger on March 7, 2008.

Employment Agreements

     Dr. Ryan resigned from her position as President and Chief Executive Officer of AVANT effective May 7, 2008 and we entered into a Separation and General Release Agreement with Dr. Ryan effective July 16, 2008 ("Ryan Separation Agreement").August 10, 2016. The Ryan Separation Agreement provides,employment agreements provide, among other things, for: (i)

    current annual base salary ($587,680 in the case of Mr. Marucci, $342,413 in the case of Mr. Catlin, $442,562 in the case of Dr. Davis, $419,761 in the case of Dr. Keler and $331,720 in the case of Ms. Crowley) or such greater amount as may from time to time be determined by the Board of Directors or the Compensation Committee thereof;

    eligibility for an annual bonus with a current bonus target (60% of base salary in the case of Mr. Marucci, 40% of base salary in the case of Mr. Catlin, 40% of base salary in the case of Dr. Davis, 40% of base salary in the case of Dr. Keler and 35% of base salary in the case of Ms. Crowley);

    a lump sum severance payment equal to 100% (200% in the case of Mr. Marucci only) of the executive's then-existing annual base salary in the event that the executive's employment is terminated without cause or the executive resigns "for good reason" (as defined in the employment agreement) and 25% accelerated vesting of any unvested equity awards; and

    accelerated vesting of any unvested equity awards (as defined in the employment agreement) and a lump sum cash payment of $1,323,203, plus interest inequal to twenty-four (24) times the amount of $10,784.10, which is payable on November 8, 2008; (ii) a mutual general release; (iii) payment of insurance premiums under COBRA for 18 months; (iv) reimbursement of attorneys’ fees up to $30,000 and (v) vesting of options to purchase 153,125 shares of Company common stock (ofexecutive's highest monthly base compensation (not including bonus) during the options to purchase 612,500 shares of Company common stock which had been granted to Dr. Ryan on March 7, 2008). The remainder of Dr. Ryan’s options terminated as of July 16, 2008twenty-four month period preceding the date of termination plus 150% (200% in the Ryan Separation Agreement andcase of Mr. Marucci only) of the highest one-year annual bonus actually received by the executive during the two full fiscal years preceding the date of Dr. Ryan'stermination in the event of termination without cause or resignation from our Board of Directors.

         Prior to her resignation, the terms of Dr. Ryan's compensation were governed"for good reason" by the executive within one year immediately following employment agreement, which is no longer in effect. Dr. Ryan entered into an employment agreement with AVANT (the “agreement”), which was amended and restated as of August 20, 1998, amended as of December 23, 2002, September 18, 2003 and again as of October 19, 2007.

    -23-


    The term of the agreement would have been for 13 months from the effective date of the Merger, with rolling automatic one-year extensions. If prior to a change in control (as defined in the AVANT Immunotherapeutics, Inc. 1999 Stock Optionemployment agreement).

        The employment agreements had an initial term through December 31, 2015 (other than Ms. Crowley's employment agreement, which had an initial term through December 31, 2016) and Incentive Plan), Dr. Ryan’sshall automatically renew for additional one year terms unless either party gives ninety (90) days prior


written notice of its intent not to renew. The Company may terminate the employment had been terminated by AVANTagreements without cause, (as definedon 90-days' prior notice, or for cause, subject to a 30-day cure period in the agreement), Dr. Ryan would have been eligible to receive a lump sum amount equal to one year’s salary, at the rate then in effect, and continuation of group health plan benefits for a period of up to twelve (12) months. If within a year after a change in control, Dr. Ryan’s employment had been terminated by AVANT without cause or by Dr. Ryan for good reason (as defined in the agreement), or if a change in control had occurred within one (1) year after Dr. Ryan is terminated without cause by AVANT, Dr. Ryan would have been entitled to receive a lump sum amount equal to three (3) times the base amount (as defined in Section 280G(b)(3) of the Internal Revenue Code of 1986, as amended) applicable to Dr. Ryan, less one dollar ($1.00). Such severance may have been further reduced to the extent necessary to preserve AVANTs tax deduction. Further, if Dr. Ryan’s employment had been terminated by AVANT without cause or by Dr. Ryan for good reason at any time after the Merger, or Dr. Ryan resigned or was terminated by AVANT or after the first anniversary of the Merger for any reason, AVANT would have been required to pay Dr. Ryan a special retirement payment of $1,323,203. In September 2005, November 2004 and September 2003, AVANT also awarded Restricted Stock Units to Dr. Ryan and recorded non-cash deferred compensation amounting to $270,000, $832,000 and $1,104,000, respectively. On September 21, 2006, AVANT’s Board of Directors modified these Restricted Stock Units to provide that they vest in their entirety upon the earlier of the sale of AVANT or Dr. Ryan’s retirement at or after age 65. Dr. Ryan reached age 65 in December 2006. These units will be settled in shares of common stock of AVANT upon a change in control of AVANT.certain circumstances.

     Dr. Cooke resigned from the Company on February 11, 2008. In connection with his resignation, the Company and Dr. Cooke entered into a letter agreement dated February 11, 2008 (“Cooke Separation Agreement”) which provided for, among other things, (i) the continuation of Dr. Cooke base salary through October 22, 2008 in accordance with the Company’s standard bi-weekly pay-roll schedule; (ii) the payment of COBRA healthcare premiums through the earlier of October 22, 2008 or Dr. Cooke becomes eligible for alternate healthcare coverage; and (iii) general release by Dr. Cooke.

     Prior to his resignation, Dr. Cooke’s compensation was governed by the terms of a letter agreement with AVANT dated June 10, 2004 (the “Letter Agreement”), which is no longer in effect and which provided for AVANT’s employment of Dr. Cooke, as a Senior Vice President of Commercial Development, beginning on June 21, 2004. Under the terms of the Letter Agreement, if (1) there had been a Change of Control of AVANT (as defined in the Letter Agreement) and Dr. Cooke’s employment was thereafter terminated by Dr. Cooke for other than Good Reason (as defined in the Letter Agreement), or (2) there had been a Change of Control of AVANT and Dr. Cooke’s employment was thereafter terminated for Cause (as defined in the Letter Agreement) by AVANT, death, Disability or Retirement (each as defined in the Letter Agreement), then no benefits would have been payable to Dr. Cooke. If Dr. Cooke’s employment was terminated within one (1) year following a Change in Control of AVANT by Dr. Cooke for Good Reason or by AVANT other than for Cause, death, Disability or Retirement, then Dr. Cooke’s benefits would have been those described in the Letter Agreement, including the continuance of Dr. Cooke’s base salary for 12 months and a 100% vesting of all unvested options.

-24-


On June 14, 2004, Dr. Cooke’s employment terms were amended (the “Amended Letter Agreement”) such that AVANT agreed to pay Dr. Cooke six months of severance (at the rate of his final base pay) if Dr. Cooke’s employment were terminated by AVANT without cause. This Amended Letter Agreement provided that Dr. Cooke was employed on an at-will basis and also allowed for Dr. Cooke to receive health and dental benefits during this severance period. Dr. Cooke was promoted to Chief Operating Officer March 21, 2005; however, his employment terms pursuant to this Letter Agreement remained the same. Dr. Cooke resigned from AVANT on February 11, 2008.

     Mr. Catlin and Dr. Marsh have agreements with AVANT under which each is eligible for a severance payment of twelve months’ base salary, continuation of health insurance benefits for twelve months and 100% vesting of all stock option grants in the event of his termination following a change-of-control, as defined in the AVANT Immunotherapeutics, Inc. 1999 Stock Option and Incentive Plan.


Pension Benefits

        None of our Named Executive Officers participate in qualified or nonqualified defined benefit plans sponsored by AVANT.us.


Nonqualified Deferred Compensation

        None of our Named Executive Officers are covered by a defined contribution or other plan that provides for the deferral of compensation on a basis that is not tax-qualified.


Potential Payments Upon Termination of Employment or Change in Control

        Certain of ourOur Named Executive Officers have provisions in their employment agreements regarding severance upon certain termination events or acceleration of stock options in the event of aour change of control of AVANT or termination following a change of control. These severance and acceleration provisions are described in “Employment"Employment Agreements," and certain estimates of these change of control benefits are provided in the tabletables below.


Una S. Ryan, Ph.D.

     Dr. Ryan's employment terminated on May 7, 2008. The payments and benefits that Dr. Ryan actually received upon termination of her employment are governed by the terms of the Ryan Separation Agreement. The following table describing the potential payments and benefits upon employment termination for Una S. Ryan, President and Chief Executive Officer, as if her employment terminated as of December 31, 2007, the last business day of our latest fiscal year is being provided in response to specific requirements of the proxy statement rules.

-25-



Executive benefits and paymentsVoluntary resignationVoluntary resignationTermination byTermination byVoluntary termination
upon terminationfor no good reasonfor good reasonAVANT not for causeAVANT for causeby the executive for
good reason or
termination by AVANT
without cause in
connection with or
following change of
                         control
Base Salary $          --- (1)$          --- (1) $     440,000$          ---$1,249,000
Equity Awards Acceleration ---  ------ --- ---
Continuation of Health Benefits------ 11,128------
Total$ ---$---$451,128$---$1,249,000

(1) AVANT would have been required to pay Dr. Ryan an amount equal to her salary prorated only for the period of time for which AVANT waives the 60 days prior notice of termination as required under the agreement.

M. Timothy Cooke, Ph.D.

     Dr. Cooke's resigned on February 11, 2008. The payments and benefits that M. Timothy Cooke actually received upon termination of his employment are governed by the terms of the Cooke Separation Agreement. The following table describing the potential payments and benefits upon employment termination for M. Timothy Cooke, Chief Operating Officer, as if his employment terminated as of December 31, 2007, the last business day of our latest fiscal year is being provided in response to specific requirements of the proxy statement rules.

Executive benefits and paymentsVoluntary resignationVoluntary resignationTermination byTermination by Voluntary termination
upon terminationfor no good reasonfor good reasonAVANT not for causeAVANT for causeby the executive for
good reason or
                    termination by AVANT
without cause in
connection with or
 following change of
                         control
Base Salary------$142,500$---$285,000
Equity Awards Acceleration ---------------
Continuation of Health Benefits------6,108--- 12,216
Total------$148,608$---$297,216

Avery W. Catlin

        The following table describes the potential payments and benefits upon employment termination for Avery W. Catlin, Chief Financial Officer,our Named Executive Officers as if histheir employment had terminated as of December 31, 2007,2016.

Executive benefits and payments
upon termination
 Voluntary
resignation
for no good
reason
 Voluntary
resignation
for good
reason(1)
 Termination
by Celldex not
for cause(1)
 Termination
by Celldex
for cause
 Voluntary termination
by the executive
for good reason
or termination by
Celldex without
cause in connection
with or following
change of control(2)
 

Anthony S. Marucci

                

Base Salary

 $ $1,175,360 $1,175,360 $ $1,175,360 

Bonus

          605,848 

Equity Awards Acceleration(3)

           

Continuation of Health Benefits

    48,046  48,046    48,046 

Total

 $ $1,223,406 $1,223,406 $ $1,829,254 

Avery W. Catlin

                

Base Salary

 $ $342,413 $342,413 $ $684,827 

Bonus

          195,000 

Equity Awards Acceleration(3)

           

Continuation of Health Benefits

    35,526  35,526    35,526 

Total

 $ $377,939 $377,939 $ $915,353 

Thomas Davis, M.D.

                

Base Salary

 $ $442,562 $442,562 $ $885,125 

Bonus

          247,500 

Equity Awards Acceleration(3)

           

Continuation of Health Benefits

    48,046  48,046    48,046 

Total

 $ $490,608 $490,608 $ $1,180,671 

Tibor Keler, Ph.D.

                

Base Salary

 $ $419,761 $419,761 $ $839,522 

Bonus

          238,500 

Equity Awards Acceleration(3)

           

Continuation of Health Benefits

    48,046  48,046    48,046 

Total

 $ $467,807 $467,807 $ $1,126,068 

Elizabeth Crowley

                

Base Salary

 $ $331,720 $331,720 $ $663,440 

Bonus

          180,000 

Equity Awards Acceleration(3)

           

Continuation of Health Benefits

           

Total

 $ $331,720 $331,720 $ $843,440 

(1)
Upon termination without cause or resignation for good reason, the employee is generally entitled to a lump sum payment equal to 100% (200% in the case of Mr. Marucci only) of the employee's then annual base salary, continuation of certain employee benefits and 25% accelerated vesting of any unvested equity awards.

(2)
The employee is generally entitled to accelerated vesting of any unvested equity awards (as defined in the employment agreement) and a lump sum cash payment equal to twenty-four (24) times the executive's highest monthly base compensation (not including bonus) during the twenty-four month

    period preceding the date of termination plus 150% (200% in the case of Mr. Marucci only) of the highest one-year annual bonus actually received by the executive during the two full fiscal years preceding the date of termination in the event of termination without cause or resignation "for good reason" by the executive within one year immediately following a change in control (as defined in the employment agreement).

(3)
The value of each share subject to an option to purchase common stock that would be accelerated in the circumstances described above equals $3.54 per share (the closing price on the last businesstrading day of our latest fiscal year.

-26-



Executive benefits and paymentsVoluntary resignationVoluntary resignationTermination byTermination by Voluntary termination
upon terminationfor no good reasonfor good reasonAVANT not for causeAVANT for causeby the executive for
good reason or
termination by AVANT
without cause in
connection with or
following change of
control
Base Salary---------251,121
Equity Awards Acceleration---------------
Continuation of Health Benefits---------12,216
Total---------263,337

     The following table describes2016), minus the potential payments and benefits upon employment termination for Henry C. Marsh, Jr., Ph.D., Vice President, Research, as if his employment terminated as of December 31, 2007, the last business day of our latest fiscal year.

exercise price per share;


Executive benefits and payments

Voluntary resignationVoluntary resignationTermination byTermination by Voluntary termination
upon terminationfor no good reasonfor good reasonAVANT not for causeAVANT for causeby the executive for
good reason or
termination by AVANT
without cause in
connection with or
following change of
control
Base Salary---------201,899
Equity Awards Acceleration---------------
Continuation of Health Benefits---------12,216
Total---------214,115

Director Compensation

        The following director compensation policy was in effect for fiscal 2007.Effective June 2016, Directors who are not our employees of AVANT are each entitled to receive a retainer fee of $20,000 each fiscal year, with the Chairman of the Board of Directors receiving $30,000. Each Committee Chairman receives an annual additional retainer fee of $5,000 and an option to purchase 2,500 shares of common stock, with the Audit Committee Chairman receiving $10,000 and an option to purchase 5,000 shares of common stock. In addition, each non-employee director is entitled to receive $2,000 for attendance at each meeting in person and $1,000 for each telephonic meeting of the Board of Directors and $1,000 for attendance at each meeting in person and $500 for each telephonic meeting of a Committee of the Board of Directors. The AVANT 1999 Stock Option and Incentive Plan provides for annual automatic grants to each independent director of an option to purchase 10,000 shares of common stock with vesting after one year, a ten year term, and an exercise price equal to the fair market value of the common stock on the day of grant. As of January 16, 2008, the current independent directors had the following stock options outstanding: Harry H. Penner, Jr.—100,000, Karen Shoos Lipton—78,500, and Larry Ellberger—65,000.

-27-


     Effective March 8, 2008, the following director non-equity compensation policy was adopted. Directors who are not employees of AVANT are each entitled to receive a retainer fee of $50,000$45,000 each fiscal year ("Annual Retainer"). The Chairman of the Board is entitled to receive an annual retainer fee of $40,000 in addition to his or her Annual Retainer and any retainer for committee service. The Chairperson of each committeethe Audit Committee of the Board of Directors is entitled to receive an annual retainer fee of $30,000 in addition to his or her Annual Retainer. The Chairperson of the Compensation and Nominating and Corporate Governance Committees of the Board of Directors is entitled to receive an annual retainer fee of $25,000 in addition to his or her Annual Retainer. Each committee member (other than the Chairperson of a committee) will receive an annual retainer of $20,000$15,000 in addition to his or her Annual Retainer. Each Director who resides outside the Unites States shall receive an additional stipend of $20,000. Stipends and retainers shall beare paid in advance on a quarterly basis. The Directors shall be reimbursed for necessary travel and business expenses as incurred but will not receive any additional fees for attending meetings or calls of the Board of Directors.

        ThisNew board members receive an initial stock option grant to purchase 8,000 shares of the Company's common stock upon joining the Board. In 2016, all non-employee directors received (i) an annual grant of 10,000 shares of restricted stock each year and (ii) an annual stock option grant to purchase 15,000 shares of the Company's common stock following the Annual Meeting of Stockholders.

        As of December 31, 2016, our non-employee directors had the following stock options outstanding: Larry Ellberger—41,300, Herbert J. Conrad—59,179, George O. Elston—59,179, Gerald McMahon—8,000, Harry H. Penner, Jr.—41,300 and Karen L. Shoos—41,300.

        The following table summarizes the annual cash compensation for AVANT’sour non-employee directors during 2007.2016.

Name
 Fees
Earned or
Paid in Cash
($)
 Stock
Awards
($)(1)
 Option
Awards
($)(2)
 Non-Equity
Incentive Plan
Compensation
($)
 Change in
Pension
Value and
Nonqualified
Deferred
Compensation
Earnings
 All Other
Compensation
($)
 Total
($)
 

Larry Ellberger

  113,750  47,200  47,256        208,206 

Herbert J. Conrad

  76,250  47,200  47,256        170,706 

George O. Elston(3)

  81,250  47,200  47,256        175,706 

Gerald McMahon

  9,625    20,062        29,687 

Harry H. Penner, Jr. 

  78,750  47,200  47,256        173,206 

Karen L. Shoos

  77,500  47,200  47,256        171,956 

Richard A. van den Broek(4)

  68,069  47,200  47,256        162,525 

(1)
The amounts in the Stock Awards column reflect the grant date fair value in accordance with U.S. GAAP of restricted stock awards made in 2016 to each of our non-employee directors for awards pursuant to the 2008 Plan subject to a vesting schedule whereby an equal number of the shares of common stock shall become vested and no longer be subject to risk of forfeiture (so long

    Director Compensation - 2007as the director remains a member of the Board as of such date). For a discussion regarding the valuation of our stock awards for financial statement reporting purposes, please refer to Note 2 in the Notes to the Financial Statements contained in our Annual Report on Form 10-K for the year ended December 31, 2016. These amounts do not represent the actual amounts paid to the directors or the actual value that may be realized by the directors for these awards during the year ended December 31, 2016.

    FeesStockOptionNon-EquityChange inAll OtherTotal
    Earned or AwardsAwardsIncentive PlanPension ValueCompensation ($) 
    Paid in($)($)Compensationand($)
    Cash($)(1)Nonqualified
    ($)Deferred
    Compensation
    Earnings 
    Name($)
    J. Barrie Ward(2)2,625---4,785---------7,410
    Harry H. Penner, Jr.43,750---8,999---------52,749
    Peter A. Sears(3)38,000---10,116---------48,110
    Karen Shoos Lipton38,125---9,227---------47,352
    Larry Ellberger42,750---10,116---------52,866
    Alf Lindberg(4)27,625---8,339---------35,964
    Francis Cano(5)30,125---9,227---------  39,352

    (1)

(2)
The amounts in the Option Awards column reflect the dollar amounts recognizedgrant date fair value in accordance with U.S. GAAP of stock option awards made in 2016 to each of our non-employee directors for awards pursuant to the 2008 Plan subject to a vesting schedule whereby an equal number of the shares of common stock shall become vested and no longer be subject to risk of forfeiture (so long as the director remains a member of the Board as of such date). For a discussion regarding the valuation of our stock option awards for financial statement reporting purposes, for the fiscal year ended December 31, 2007, in accordance with FAS 123(R), (excluding the impact of estimated forfeitures relatedplease refer to service-based vesting conditions), for awards pursuant the AVANT 1999 Stock Option and Incentive Plan, and thus may include amounts attributable to awards granted during and before 2007 and 2006. Assumptions madeNote 2 in the calculation of these amounts are included in Note 5Notes to our Consolidatedthe Financial Statements contained in our annual reportAnnual Report on Form 10-K for the year ended December 31, 2007.2016. These numbersamounts do not reflectrepresent the 1-for-12 reverseactual amounts paid to the directors or the actual value that may be realized by the directors upon exercise of such stock split effected on March 7, 2008.

(2) Dr. Wardoptions.

(3)
Mr. Elston's term as director will expire at the 2017 Annual Meeting.

(4)
On December 14, 2016, Mr. van den Broek resigned from the Board, effective immediately, due to increasing responsibilities in other endeavors.

        In addition, on November 28, 2016, in connection with Dr. McMahon's employment separation with Kolltan Pharmaceuticals, Inc., we entered into a severance agreement with Dr. McMahon whereby we agreed to pay Dr. McMahon up to 267,356 shares of Directors effective April 17, 2007.our common stock less required tax and other withholdings. To date, 64,667 shares of common stock were issued to Dr. McMahon, 35,796 shares have been withheld to satisfy tax withholdings and the remaining 166,893 shares of common stock, less applicable withholdings, are issuable to Dr. McMahon in equal monthly installments through December 2018.

-28-


(3) Mr. Sears resigned from the Board of Directors effective November 26, 2007.

(4) Dr. Lindberg resigned from the Board of Directors effective January 15, 2008.

(5) Dr. Cano resigned from the Board of Directors effective October 16, 2007.


Compensation Committee Interlocks and Insider Participation

        The Compensation Committee of the Board of Directors wasis currently composed at various times during 2007 byof the following sixthree non-employee directors: Messrs.James J. Barrie Ward, Francis Cano, Peter A. Sears,Marino, Chair, Herbert J. Conrad and Harry H. Penner, Jr. and Alf Lindberg and Ms. Karen Shoos Lipton. None of these Compensation Committee members was an officer or employee of AVANTus during the year. Dr. Ward was formerly an employee of AVANT and was a consultant for AVANT until December 31, 2004. Dr. Ward did not participate in actions or discussions with respect to his own compensation. No Compensation Committee interlocks between AVANT and another entity existed. During 2008, the Compensation Committee of the Board of Directors was composed at various times by the following five non-employee directors: Messrs. Harry H. Penner, Jr., Larry Ellberger, Dr. Rajesh B. Parekh and Charles R. Schaller and Ms. Karen Shoos Lipton. No Compensation Committee interlocks between AVANTus and another entity existed.


REPORT OF THE AVANT COMPENSATION COMMITTEE*Risk Considerations

        We do not believe that our compensation practices and policies for our employees, including our executive officers, create risks or are likely to create risks that are reasonably likely to have a material adverse effect on our results of operations or financial condition. The Compensation Committee considered our strategic goals and operational practices and evaluated our incentive program design to assess whether these programs foster a business environment that might drive inappropriate decision-making or behavior. We are a biopharmaceutical company that is generating a pipeline of AVANTdrug candidates to treat cancer and other difficult-to-treat diseases and do not yet generate earnings. While a significant portion of our executives' compensation is performance-based, we believe several features of our program mitigate inappropriate or excessive risk-taking that could harm shareholder value: we set performance goals that we believe are reasonable and set targets with payouts at multiple levels of performance, rather than an "all or nothing" approach. As discussed above in our Compensation Discussion and Analysis section we use a mix of performance goals in our annual and long-term incentive programs to align incentive compensation with a broad set of measures important to the creation of shareholder value.



COMPENSATION COMMITTEE REPORT*

        Our Compensation Committee has reviewed and discussed the Compensation Discussion and Analysis with management and based on asuch review and discussion of the Compensation Discussion and Analysis, the Compensation Committee recommended to the Board of Directors that the Compensation Discussion and Analysis be included in the Company's Annual Report on Form 10-K andthis proxy statement on Schedule 14A.statement.

                        Compensation CommitteeCommittee:
                        Karen Shoos Lipton, ChairmanJames J. Marino, Chair
                        Herbert J. Conrad
                        Harry H. Penner, Jr.
                        Larry Ellberger


*
The foregoing report of the Compensation Committee is not to be deemed “soliciting material”"filed" with the SEC (irrespective of any general incorporation language in any document filed with the SEC) or subject to Regulation 14A of the Securities Exchange Act of 1934, as amended, or to the liabilities of Section 18 of the Securities Exchange Act of 1934, except to the extent we specifically incorporate it by reference into a document filed with the SEC.


REPORT OF THE AUDIT COMMITTEE*

        The undersigned members of the Audit Committee of the Board of Directors of Celldex submit this report in connection with the committee's review of the financial reports for the fiscal year ended December 31, 2016 as follows:

    1.
    The Audit Committee has reviewed and discussed with management the audited financial statements for Celldex for the fiscal year ended December 31, 2016.

    2.
    The Audit Committee has discussed with representatives of PricewaterhouseCoopers LLP the matters which are required to be discussed with them under the provisions of Auditing Standard No. 1301,Communications with Audit Committees. That Auditing Standard requires the auditors to ensure that the Audit Committee received information regarding the scope and results of the audit.

    3.
    The Audit Committee has discussed with PricewaterhouseCoopers LLP, the independent registered public accounting firm, the auditors' independence from management and Celldex including the matters in the written disclosures and the letter from the independent auditors required by PCAOB Rule 3526.

        In addition, the Audit Committee considered whether the provision of tax or other non-audit services by PricewaterhouseCoopers LLP is compatible with maintaining its independence. In reliance on the reviews and discussions referred to above, the Audit Committee recommended to the Board of Directors (and the Board of Directors has approved) that the audited financial statements be included in Celldex's Annual Report on Form 10-K for the fiscal year ended December 31, 2016 for filing with the Securities and Exchange Commission.

                        Audit Committee:
                        George O. Elston, Chair
                        Larry Ellberger
                        Harry H. Penner, Jr.


*
The foregoing report of the Audit Committee is not to be deemed "soliciting material" or deemed to be “filed”"filed" with the Securities and Exchange Commission (irrespective of any general incorporation language in any document filed with the Securities and Exchange Commission) or subject to Regulation 14A of the Securities Exchange Act of 1934, as amended, or to the liabilities of Section 18 of the Securities Exchange Act of 1934, except to the extent we specifically incorporate it by reference into a document filed with the Securities and Exchange Commission.

-29-


REPORT OF THE AUDIT COMMITTEE*

     The undersigned members of the Audit Committee of the Board of Directors of AVANT submit this report in connection with the committee’s review of the financial reports for the fiscal year ended December 31, 2007 as follows:

1.The Audit Committee has reviewed and discussed with management the audited financial statements for AVANT for the fiscal year ended December 31, 2007.
2.The Audit Committee has discussed with representatives of PricewaterhouseCoopers LLP the matters which are required to be discussed with them under the provisions of SAS 61. That Statement of Accounting Standards requires the auditors to ensure that the Audit Committee received information regarding the scope and results of the audit. PricewaterhouseCoopers LLP has also communicated with the Audit Committee on matters required by Rule 2-07 of Regulation S-X.
3.The Audit Committee has discussed with PricewaterhouseCoopers LLP, the independent public accounting firm, the auditors’ independence from management and AVANT including the matters in the written disclosures and the letter from the independent auditors required by the Independence Standards Board, Standard No. 1.

     In addition, the Audit Committee considered whether the provision of information technology services or other non-audit services by PricewaterhouseCoopers LLP is compatible with maintaining its independence. In reliance on the reviews and discussions referred to above, the Audit Committee recommended to the Board of Directors (and the Board of Directors has approved) that the audited financial statements be included in AVANT’s Annual Report on Form 10-K for the fiscal year ended December 31, 2007 for filing with the Securities and Exchange Commission.

Audit Committee
Larry Ellberger, Chairman
Harry H. Penner, Jr.
George O. Elston

*The foregoing report of the Audit Committee is not to be deemed “soliciting material” or deemed to be “filed” with the Securities and Exchange Commission (irrespective of any general incorporation language in any document filed with the Securities and Exchange Commission) or subject to Regulation 14A of the Securities Exchange Act of 1934, as amended, or to the liabilities of Section 18 of the Securities Exchange Act of 1934, except to the extent we specifically incorporate it by reference into a document filed with the Securities and Exchange Commission.

Security Ownership of Certain Beneficial Owners and Management

        The following table sets forth certain information as of August 5, 2008April 10, 2017 with respect to the beneficial ownership of common stock of the Company by the following: (i) each of the Company's current directors; (ii) each of the director nominees; (iii) each of the Named Executive Officers; (iii)(iv) the current executive officers; (iv)(v) all of the executive officers and directors as a group; and (v)(vi) each person known by the Company to own beneficially more than five percent (5%) of the outstanding shares of the Company's common stock.

-30-


        For purposes of the following table, beneficial ownership is determined in accordance with the applicable SEC rules and the information is not necessarily indicative of beneficial ownership for any other purpose. Except as otherwise noted in the footnotes to the table, we believe that each person or entity named in the table has sole voting and investment power with respect to all shares of the Company’sCompany's common stock shown as beneficially owned by that person or entity (or shares such power with his or her spouse). Under the SEC’sSEC's rules, shares of the Company’sCompany's common stock issuable under options that are exercisable on or within 60 days after August 5, 2008 (“April 10, 2017 ("Presently Exercisable Options”Options") are deemed outstanding and therefore included in the number of shares reported as beneficially owned by a person or entity named in the table and are used to compute the percentage of the common stock beneficially owned by that person or entity. These shares are not, however, deemed outstanding for computing the percentage of the common stock beneficially owned by any other person or entity.


        The percentage of the common stock beneficially owned by each person or entity named in the following table is based on 15,708,244125,104,714 shares of common stock outstanding as of August 5, 2008April 10, 2017 plus any shares issuable upon exercise of Presently Exercisable Options held by such person or entity.

Name and Business Address of Beneficial Owners*Amount and Nature ofPercentage of Common
    Beneficial Ownership(1)    Stock(2) 
Medarex, Inc.(3)4,960,848(4)31.6%
Apax WW Nominees Ltd.1,384,6638.8
Pfizer Vaccines781,2505
Directors and Executive Officers
Charles R. Schaller14,882(5)**
Herbert J. Conrad17,879(6)**
Larry Ellberger-(7)-
George O. Elston17,879(6) **
Karen Shoos Lipton333(7)**
Dr. Rajesh B. Parekh17,879(8)**
Harry H. Penner, Jr.416(9)**
Anthony S. Marucci181,380(10)1.6
Avery W. Catlin 47,624(11)**
Dr. Thomas Davis43,364(12)**
Tibor Keler 181,380(10)1.6
Dr. Ronald C. Newbold27,645(13)**
Named Executive Officers (Other than those set forth above)
Una S. Ryan, Ph.D.314,058(14)2.0
Henry C. Marsh, Jr., Ph.D.22,569(15)**
Taha Keilani, M.D.166(16)**
Timothy Cooke -(17)-
Ronald Ellis -(18)-
All Directors and Executive Officers as a group
(Consisting of 12 persons)550,661(19)                   3.4256%

Name and Business Address of Beneficial Owners*
 Amount and Nature
of Beneficial
Ownership(1)
 Percentage of
Common Stock(2)
 

5% Holders

       

FMR LLC
245 Summer Street
Boston, MA 02210

  19,330,211(3) 15.5%

BlackRock, Inc.
55 East 52nd Street
New York, NY 10055

  7,889,061(4) 6.3%

The Vanguard Group
100 Vanguard Blvd.
Malvern, PA 19355

  7,788,557(5) 6.2%

KLP Enterprises, LLC
35 Windsor Road,
North Haven, CT 06473

  6,865,006(6) 5.5%

Franklin Resources, Inc.
One Franklin Parkway
San Mateo, CA 94403-1906

  6,233,265(7) 5.0%

Columbia Wanger Asset Management, LLC
227 West Monroe Street, Suite 3000
Chicago, IL 60606

  6,195,855(8) 5.0%

Directors and Executive Officers

       

Keith L. Brownlie

    ** 

Avery W. Catlin

  519,559(9) ** 

Herbert J. Conrad

  70,962(10) ** 

Elizabeth Crowley

  176,758(11) ** 

Thomas Davis, M.D. 

  833,495(12) ** 

Larry Ellberger

  88,083(13) ** 

George Elston

  70,962(14) ** 

Tibor Keler, Ph.D. 

  936,013(15) ** 

Theresa LaVallee, Ph.D. 

    ** 

Anthony S. Marucci

  1,773,823(16) 1.4%

James J. Marino

  15,997  ** 

Gerald McMahon, Ph.D. 

  231,560(17) ** 

Harry H. Penner, Jr. 

  56,499(18) ** 

Ronald Pepin, Ph.D. 

  400,374(19) ** 

Karen L. Shoos

  56,416(20) ** 

Richard Wright, Ph.D

  101,560(21) ** 

All Directors and Executive Officers as a group (16 persons)

  5,332,061(22) 4.1%

*
Unless otherwise indicated, the address is c/o AVANT Immunotherapeutics,Celldex Therapeutics, Inc., 119 Fourth Avenue, Needham, Massachusetts 02494-2725.

Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827.

**
Less than 1%.


(1)
Unless otherwise indicated, the persons shown have sole voting and investment power over the shares listed.

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(2)
Common stock includes all outstanding common stock plus, as required for the purpose of determining beneficial ownership (in accordance with Rule 13d-3(d)(1) of the Securities Exchange Act of 1934, as amended), all common stock subject to any right of acquisition, through exercise or conversion of any security, within 60 days of the record date.



(3)
Based solely on information set forth in a Schedule 13G/A filed with the SEC on February 14, 2017 by FMR LLC ("FMR") reporting that FMR: (i) beneficially owned 19,330,211 shares, including 7,827,066 shares held in the name of Fidelity Select Biotechnology Portfolio.; (ii) had the sole power to dispose or direct the disposition of 19,330,211 shares; and (iii) had the sole power to vote or to direct the vote of 1,911,665 shares. In addition, the Schedule 13G/A shows that the following entities beneficially own certain of the shares reported: FMR Co., Inc. (beneficially owns 5% or more) and Fidelity Institutional Asset Management Trust Company. The principal business address for Medarex, Inc.,Schedule 13G/A also shows that Abigail P. Johnson is a New Jersey corporation ("Medarex") is 707 State Road, Princeton, New Jersey 08540.

(4) Represents 4,960,848Director, the Chairman and the Chief Executive Officer of FMR. Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of common stock which Medarex acquired as a resultFMR, representing 49% of the Merger. Medarexvoting power of FMR. The Johnson family group and all other Series B shareholders have entered into a shareholders' voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders' voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to haveform a controlling group with respect to FMR. Neither FMR nor Abigail P. Johnson has the sole power to vote or direct the voting of the shares owned directly by the various investment companies registered under the Investment Company Act (the "Fidelity Funds"), advised by Fidelity Management & Research Company, a wholly-owned subsidiary of FMR, which power resides with the Fidelity Funds' Board of Trustees. Fidelity Management & Research Company carries out the voting of the shares under written guidelines established by the Fidelity Funds' Board of Trustees.

(4)
Based solely on information set forth in a Schedule 13G/A filed with the SEC by BlackRock, Inc. on January 23, 2017 reporting sole power to vote or direct the vote over 7,680,798 shares and the sole power to dispose or to direct the disposition of such7,889,061 shares.

(5)
Based solely on information set forth in a Schedule 13G/A filed with the SEC by The Vanguard Group on February 10, 2017, reporting sole power to vote or direct the vote over 116,747 shares, shared power to vote or direct the vote over 4,641 shares, sole power to dispose or to direct the disposition of common stock. To7,672,269 shares and shared dispositive power over 116,288 shares. The shares reported include 111,647 shares held by Vanguard Fiduciary Trust Company, a wholly-owned subsidiary of The Vanguard Group, Inc. and 9,741 shares held by Vanguard Investments Australia, Ltd., a wholly-owned subsidiary of The Vanguard Group, Inc.

(6)
Based solely on information set forth in a Schedule 13G filed with the extent thatSEC by KLP Enterprises, LLC on December 9, 2016 reporting shared voting and dispositive power with regard to 6,865,006 shares. As the directorsmanager of MedarexKLP Enterprises, LLC, Andrew D. Wingate may be deemed to share beneficial ownership with respect to shares held by KLP Enterprises, LLC.

(7)
Based solely on information set forth in a Schedule 13G/A filed with the SEC by Franklin Resources, Inc. on February 9, 2017, reporting that Franklin Advisers, Inc. has the sole power to vote (andor direct the vote of)over 6,200,365 shares and has sole power to dispose or dispose of (or direct the disposition of) suchof 6,200,365 shares and Fiduciary Trust Company International has the sole power to vote or direct the vote over 32,900 shares and the sole power to dispose or direct the disposition of 32,900 shares. The securities are beneficially owned by one or more open- or closed-end investment companies or other managed accounts that are investment management clients of investment managers that are direct and indirect subsidiaries (each, an "Investment Management Subsidiary" and, collectively, the "Investment Management Subsidiaries") of Franklin Resources Inc. ("FRI"). The voting and investment powers held by Franklin Mutual Advisers, LLC ("FMA"), an indirect wholly-owned Investment Management Subsidiary, are exercised independently from FRI and from all other Investment Management Subsidiaries. Charles B. Johnson and Rupert H. Johnson, Jr. (the "Principal Shareholders") each own in excess of 10% of the outstanding common stock of FRI and are the principal stockholders of FRI. FRI, the Principal Shareholders and each of the Investment Management Subsidiaries believe that they are not acting as a "group" and that the shares held by each other need not be aggregated for purposes of Section 13(d).

(8)
Based solely on information set forth in a Schedule 13G filed with the SEC by Columbia Wagner Asset Management, LLC (CWAM) on February 10, 2017 reporting that CWAM beneficially owns 6,195,855 shares, of which 6,019,590 shares are held by Columbia Acorn Fund and the remaining shares are held by various other funds or accounts managed by CWAM. CWAM does not directly own any shares of common stock owned of recordthe issuer. As the investment adviser of Columbia Acorn Fund and various other investment companies and managed accounts, CWAM may be deemed to beneficially own the shares reported herein by Medarex, each such directorColumbia Acorn Fund and by various other funds or accounts managed by CWAM. CWAM disclaims beneficial ownership of theany shares reported herein.

(9)
Includes 430,527 shares of common stock owned by Medarex.

(5) Represents 14,882underlying options which are or may be exercisable as of April 10, 2017 or 60 days after such date.

(10)
Includes 49,129 shares of common stock issuable upon the exerciseunderlying options which are or may be exercisable as of Presently Exercisable Options. Does not include 4,960,848April 10, 2017 or 60 days after such date.

(11)
Includes 169,436 shares of common stock owned by Medarex. Mr. Schaller is a director of Medarex and to the extent that by virtue of his role as director Mr. Schallerunderlying options which are or may be deemed to share the power to vote (and direct the vote of)exercisable as of April 10, 2017 or dispose of (or direct the disposition of)60 days after such date.

(12)
Includes 825,127 shares of common stock ownedunderlying options which are or may be exercisable as of record by Medarex, Mr. Schaller disclaims beneficial ownership of theApril 10, 2017 or 60 days after such date.

(13)
Includes 31,250 shares of common stock owned by Medarex.

(6) underlying options which are or may be exercisable as of April 10, 2017 or 60 days after such date.

(14)
Includes 17,87949,129 shares of common stock issuable upon exerciseunderlying options which are or may be exercisable as of Presently Exercisable Options.

(7) Excludes 17,728April 10, 2017 or 60 days after such date.

(15)
Includes 917,145 shares of common stock issuable upon exercise ofunderlying options which will not vest withinare or may be exercisable as of April 10, 2017 or 60 days of August 5, 2008.

(8) after such date.

(16)
Includes 17,8791,721,391 shares of common stock issuable upon exerciseunderlying options which are or may be exercisable as of Presently Exercisable Options. Does not include 56,223 shareApril 10, 2017 or 60 days after such date.

(17)
On November 28, 2016, in connection with Dr. McMahon's employment separation with Kolltan Pharmaceuticals, Inc., we entered into a severance agreement with Dr. McMahon whereby we agreed to pay Dr. McMahon up to 267,356 shares of our common stock held by an entity, which is owned in part by Dr. Parekhless

    required tax and his spouse. Dr. Parekh disclaims beneficial ownership of such shares and is not involved in any decision making with respect to the disposition of such shares.

    (9) Includes 416other withholdings. To date, 64,667 shares of common stock issuable upon exercise of Presently Exercisable Options. Excludes 17,728were issued to Dr. McMahon, 35,796 shares have been withheld to satisfy tax withholdings and the remaining 166,893 shares of common stock, less applicable withholdings, are issuable upon exercise of options, which will not vest within 60 days of August 5, 2008.to Dr. McMahon in equal monthly installments through December 2018.

    (10)

(18)
Includes 181,38031,250 shares of common stock issuable upon exerciseunderlying options which are or may be exercisable as of Presently Exercisable Options. Excludes 72,863April 10, 2017 or 60 days after such date.

(19)
Includes 400,374 shares of common stock issuable upon exercise ofunderlying options which will not vest withinare or may be exercisable as of April 10, 2017 or 60 days of August 5, 2008.

(11) after such date.

(20)
Includes 1,79131,250 shares of common stock owned directly by Mr. Catlin and 45,833underlying options which are or may be exercisable as of April 10, 2017 or 60 days after such date.

(21)
Includes 101,560 shares of common stock issuable upon exercise Presently Exercisable options. Excludes 137,500 shares of common stock issuable upon exercise ofunderlying options which will not vest withinare or may be exercisable as of April 10, 2017 or 60 days of August 5, 2008.

(12) Includes 43,364 shares of common stock issuable upon exercise Presently Exercisable options. Excludes 105,461 shares of common stock issuable upon exercise of options, which will not vest within 60 days of August 5, 2008.

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(13) Includes 27,645 shares of common stock issuable upon exercise Presently Exercisable options. Excludes 79,840 shares of common stock issuable upon exercise of options, which will not vest within 60 days of August 5, 2008.

(14) Includes 153,125 shares of common stock issuable upon exercise Presently Exercisable options. Includes 83,333 Restricted Stock Units, which are fully vested and were settled for stock on a one-for-one basis upon the consummation of the Merger on March 7, 2008. Includes 74,934 shares of common stock owned directly by Dr. Ryan and 2,666 shares owned by Dr. Ryan's husband, of which Dr. Ryan disclaims beneficial ownership. Dr. Ryan's employment with the Company terminated as of May 7, 2008 and she resigned from the Company's Board of Directors effective July 16, 2008. The information on the table is based solely upon data derived from publicly filed forms reporting her beneficial ownership and to the extent that this individual is no longer required to file forms reporting her beneficial ownershipafter such information may not be correct.

(15) Includes 486 shares owned directly by Mr. Marsh and 22,083 shares of common stock issuable upon exercise Presently Exercisable options. Excludes 20,833 shares of common stock issuable upon exercise of options, which will not vest within 60 days of August 5, 2008. Following the Merger, although Mr. Marsh continued with the Company, he was no longer deemed an executive officer.

(16) Dr. Keilani resigned from AVANT effective April 17, 2008. The information on the table is based solely upon data derived from publicly filed forms reporting his beneficial ownership and to the extent that this individual is no longer required to file forms reporting his beneficial ownership such information may not be correct.

(17) Dr. Cooke resigned from the Company as of February 11, 2008. The information on the table is based solely upon data derived from publicly filed forms reporting his beneficial ownership and to the extent that this individual is no longer required to file forms reporting his beneficial ownership such information may not be correct.

(18) Dr. Ellis resigned from the Company as of July 31, 2007. The information on the table is based solely upon data derived from publicly filed forms reporting his beneficial ownership and to the extent that this individual is no longer required to file forms reporting his beneficial ownership such information may not be correct.

(19) date.

(22)
Please refer to footnotes 59 - 13.

21.

Section 16(a) Beneficial Ownership Reporting Compliance

        Section 16(a) of the Securities Exchange Act of 1934, as amended, requires AVANT’sCelldex's directors officers and key employees,executive officers, and persons who are beneficial owners of more than 10% of a registered class of our equity securities, to file reports of ownership and changes in ownership with the Securities and Exchange Commission (the “SEC”"SEC"). Officers, directors and greater than 10% beneficial ownersThese persons are required by SEC regulations to furnish AVANTus with copies of all Section 16(a) forms they file. To our knowledge, based solely on a review of the copies of such reports furnished to us and written representations that no other reports were required during the fiscal year ended December 31, 2007,2016, all reports required to be filed under Section 16(a) filing requirements applicable to such persons were satisfied.filed on a timely basis.

-33-


Transactions with Related Persons

        It is our policy that all employees and directors, as well as their family members, must avoid any activity that is or has the appearance of conflicting with AVANT’sCelldex's business interest. This policy is included in our Code of Business Conduct and Ethics. All directors and officers of AVANTCelldex complete a directors and officers questionnaire at the beginning of each year, in which they are asked to disclose family relationships and other related party transactions. Our Audit Committee must review and approve all related party transactions, as defined in Item 404 of Regulation S-K. Our Audit Committee’sCommittee's procedures for reviewing related party transactions are not in writing. In fiscal 2007,Other than compensation arrangements for our Named Executive Officers and directors, which are described in the section entitled "Executive Compensation," since January 1, 2016, there have been no transactions or series of similar transactions to which we were no relateda party transactions.or will be a party, in which:

    the amounts involved exceeded or will exceed $120,000; and



    any of our directors, executive officers or holders of more than 5% of our capital stock, or any member of the immediate family of the foregoing persons, had or will have a direct or indirect material interest.

THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE
FOR THE ELECTION OF THE DIRECTOR NOMINEES



PROPOSAL 2: RATIFY THE APPOINTMENT OF
PRICEWATERHOUSECOOPERS LLP AS OUR INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 20082017

(Proposal No. 2)

        The Audit Committee has reappointed PricewaterhouseCoopers LLP as our independent registered public accounting firm to audit the financial statements of the Company for the fiscal year ending December 31, 2008,2017, and has further directed that management submit their selection of independent registered public accounting firm for ratification by our stockholders at the Annual Meeting of Stockholders. A representative of PricewaterhouseCoopers LLP is expected to attend the Annual Meeting and will have an opportunity to make a statement, if he or she desires, and will be available to respond to appropriate questions. Neither the accounting firm nor any of its members hashave any direct or indirect financial interest in or any connection with us in any capacity other than as public registered accounting firm.

Principal Accountant Fees and Services

        The following table summarizes the fees for professional services rendered by PricewaterhouseCoopers LLP, our independent registered public accounting firm, for each of the last two fiscal years:

Fee Category
 2016 2015 
 
 (In thousands)
 

Audit Fees

 $856 $603 

Audit-Related Fees

  42  5 

Tax Fees

  38  254 

All Other Fees

  2  11 

Total Fees

 $938 $873 

Audit Fees

        Represents fees, including out of pocket expenses, for professional services provided in connection with the audit of AVANT’sour annual audited financial statements and reviews of AVANT’sour internal control over financial reporting, the review of our quarterly financial statements included in our Forms 10-Q, accounting consultations or advice on accounting matters directly related tonecessary for the auditrendering of an opinion on our financial statements, services provided in connection with the offerings of our common stock and audit services provided in connection with other statutory or regulatory filings. Fees, including out of pocket expenses, for the fiscal years 2007 and 2006 audit, including assurance services provided in connection with the assessment and testing of internal controls pursuant to Section 404 of the Sarbanes-Oxley Act of 2002, quarterly reviews of Forms 10-Q during fiscal years 2007 and 2006 and in connection with the Celldex Merger entered into in 2007 were $443,400 and $374,550, respectively.

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Audit-Related Fees

        Audit-related fees are for assurance and other activities not explicitly related to the audit of AVANTsour financial statements and consisted principally of fees for consultations concerning financial accounting and reporting standards. There were no audit-related fees billed by PricewaterhouseCoopers LLP for fiscal 2007 and 2006.including due diligence in connection with the Kolltan acquisition.

Tax Fees

        Tax fees are associated with tax compliance tax advice,and tax planning and tax preparation services. In 2007 and 2006, we engaged another public accounting firm to perform these services.related activities.

All Other Fees

        OtherAll other fees consist of $1,500 were billed by PricewaterhouseCoopers LLP in fiscal years 2007 and 2006.fees relating to an accounting research tool.

        The Audit Committee is responsible for appointing, setting compensation and overseeing the work of the independent auditors. The Audit Committee has established a policy regarding pre-approval of


all auditing services and the terms thereof and non-audit services (other than non-audit services prohibited under Section 10A(g) of the Exchange Act or the applicable rules of the SEC or the Public Company Accounting Oversight Board) to be provided to AVANTCelldex by the independent auditor. However, the pre-approval requirement may be waived with respect to the provision of non-audit services for AVANTCelldex if the “de minimus”"de minimus" provisions of Section 10A(i)(1)(B) of the Exchange Act are satisfied.

        The Audit Committee has considered whether the provision of Audit-Related Fees, Tax Fees, and all other feesAll Other Fees as described above is compatible with maintaining PricewaterhouseCoopers LLP’sLLP's independence and has determined that such services for fiscal years 2007, 20062016 and 20052015 were compatible. All such services were approved by the Audit Committee pursuant to Rule 2-01 of Regulation S-X under the Exchange Act to the extent that rule was applicable.

        The Audit Committee is responsible for reviewing and discussing the auditaudited financial statements with management, discussing with the independent auditorsregistered public accountants the matters required in Auditing Standards No. 61,1301, receiving written disclosures from the independent auditorsregistered public accountants required by ISB No. 1the applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accountants' communications with the Audit Committee concerning independence and discussing with the independent auditorsregistered public accountants their independence, and recommending to the Board of Directors that the audit financial statements be included in the Company’sour annual report ofon Form 10-K.

THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE
FOR THE RATIFICATION OF THE INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM


Changes


PROPOSAL 3: APPROVAL, IN ACCORDANCE WITH THE APPLICABLE RULES OF THE NASDAQ STOCK MARKET, OF THE ISSUANCE OF SHARES OF OUR COMMON STOCK IN CONNECTION WITH MILESTONE PAYMENTS THAT MAY BECOME PAYABLE IN THE FUTURE TO FORMER SECURITYHOLDERS OF KOLLTAN PHARMACEUTICALS, INC.

(Proposal No. 3)

Background of the Proposal

        Our acquisition of Kolltan Pharmaceuticals, Inc. (the "Kolltan Acquisition") was consummated on November 29, 2016 (the "Closing"). The terms of the Kolltan Acquisition require us to pay certain Milestone Payments (as defined and described below) to the former stockholders of Kolltan upon achievement of certain preclinical and clinical development milestones related to Kolltan's development programs and/or Celldex's development programs and certain commercial milestones related to Kolltan's product candidates after the Closing. The Milestone Payments may be paid, at our sole election, in Independent Accountants

     On March 7, 2008,cash, in shares of our common stock or a combination of both (except with respect to non-accredited former shareholders of Kolltan to whom we will pay cash). We are submitting this Proposal 3 to you in order to obtain the requisite stockholder authorization in accordance with NASDAQ Marketplace Rules so that we may make the Milestone Payments in shares of our common stock, if we so choose, as more fully described below. Although the proposal to approve the issuance of shares of our common stock to make Milestone Payments that become payable to the former stockholders of Kolltan is related to the Kolltan Acquisition, you will not be voting to approve the Kolltan Acquisition, because it has already been completed. Your vote only relates to whether any Milestone Payments, which may become due, are made only in cash, or whether the Company completedhas the mergerflexibility to make such payments in cash or stock.

Terms of CallistoKolltan Acquisition

General

        As previously reported, on November 1, 2016, we entered into the Merger Corporation (“Agreement with Kolltan, two of our wholly-owned subsidiaries, and Shareholder Representative Services LLC, solely in its capacity as the Stockholders Representative (together with its permitted successors, the "Stockholders Representative") pursuant to which we acquired Kolltan Pharmaceuticals, Inc. ("Kolltan").

        The Kolltan Acquisition closed on November 29, 2016. In addition, capitalized terms used in this "Terms of Kolltan Acquisition" section without definition shall have the meanings ascribed to such terms in the Merger Sub”), a wholly owned subsidiary of the Company with and into Celldex Therapeutics, Inc. (“Celldex”), a privately-held company (the “Merger”).Agreement.

Aggregate Merger Consideration

        Pursuant to the terms of the Merger Agreement, at the Closing we agreed to pay the following consideration to the former Kolltan securityholders:

    (1)
    An aggregate of 18,257,996 shares of our common stock to former Kolltan securityholders and an aggregate of 437,901 shares of our common stock to certain officers of Kolltan in lieu of cash severance obligations (the "Closing Merger Consideration").

    (2)
    If earned after the Company’sClosing, certain Milestone Payments in an amount of up to $172.5 million in the aggregate, payable in shares of our common stock or cash, in our sole discretion (except with respect to non-accredited former shareholders of Kolltan to whom we will pay cash), in the event of the achievement of certain preclinical and clinical development milestones related to Kolltan's development programs and/or Celldex's development programs and certain commercial milestones related to Kolltan's product candidates (each a

      "Milestone") (such payments, the "Milestone Payments", and together with the Closing Merger Consideration, the "Merger Consideration"). The Milestone Payments that may become payable after Closing (including the relevant payment procedures) are described in greater particularity under the caption "Mechanics of Milestone Payments" below.

        The Merger Consideration as provided in the Merger Agreement was negotiated at arms' length between the parties.

Payment of Closing Merger Consideration

        In accordance with the Merger Agreement, at the Closing, we issued 18,257,996 shares of our common stock to former Kolltan securityholders. In addition, we agreed to issue an aggregate of 437,901 shares of our common stock to certain officers of Kolltan, less required tax withholding, in lieu of cash severance obligations, of which 175,778 shares have been issued to date. The remaining shares, less required tax withholding, are issuable in equal monthly installments through December 2018.


Mechanics of Milestone Payments

        Subject to the terms and conditions of the Merger Agreement, upon the achievement of each of the milestones specified below, we will be required to pay to the former Kolltan stockholders the Milestone Payment specified:

Milestone
Dollar Amount of
Milestone Payment
(payable in stock or cash, in
Celldex's discretion)

Successful Completion of a Phase I Clinical Trial for KTN0158

$25.0 million

Successful Completion of a Phase II Clinical Trial for KTN3379 or KTN0158, whichever occurs first

$20.0 million

The TAM Program progresses into IND Enabling Studies but in no event prior to Successful Completion of a toxicology study in non-human primates

$10.0 million

Initiation of a Phase II(b) Clinical Trial for Varlilumab under a Partnership Agreement

$15.0 million

Successful Completion of the METRIC Study, but in no event prior to the entering into of a Partnership Agreement for world-wide rights or rights in either or both of the United States or the European Union with respect to the study compound

$10.0 million

Initiation of a Phase II Clinical Trial for any Celldex Early Stage Compound

$10.0 million

First FDA or EMA Marketing Approval of a Surviving Company Product in the U.S. or a European Market, as applicable

$50.0 million

Achievement of $200 million in Annual Net Sales for a Kolltan Product (the "First Kolltan Commercial Milestone") net of any Third-Party Payments made by Celldex, its Affiliates or its Product Transferees in connection with such Kolltan Products

$25.0 million

In the event that Celldex or Surviving Company enters into or closes one or more Partnership Agreements with respect to the TAM Program (each, a "TAM Partnership") within eighteen (18) months after the Closing, or in the event that Celldex or Surviving Company enters into or closes one or more TAM Partnerships within the six (6) months immediately thereafter with a third party with whom Celldex or the Surviving Company was in negotiations or discussions during the initial eighteen (18) month period, then the Stockholders shall receive:

payment equal to fifty percent (50%) of any Upfront Payments received by Celldex or its Affiliates under the terms of each TAM Partnership; provided, however, that any such payments shall not exceed $10.0 million in the aggregate

        Each Milestone Payment shall be payable only once, upon the first occurrence of the applicable Milestone. In addition, the first Milestone Payment to be paid (i) will be accompanied by payment of any Closing Shortfall and (ii) will be reduced by $2.5 million. We are required to notify the Stockholders Representative within 10 business days of the achievement of a Milestone (the "Milestone Date"), provided that, with respect to the First Kolltan Commercial Milestone, such notice is due within 30 days of the end of the calendar month in which the First Kolltan Commercial Milestone is achieved. We may pay each Milestone Payment in cash, shares of our common stock or a combination thereof, in our sole discretion. Shares of our common stock included in a Milestone Payment shall be valued at the Parent Stock Value as of the relevant Milestone Date. For purposes of the Merger


Agreement, "Parent Stock Value" means the average of the closing sale prices per share of our common stock as reported on the NASDAQ (or other national exchange upon which the our common stock is then listed) for the five (5) trading day period ending three (3) calendar days prior to the date such Milestone is achieved.

        The Merger Agreement provides that notwithstanding our discretion to pay each Milestone Payment in cash, shares or a combination thereof, we agree to use commercially reasonable efforts to cause a sufficient portion of each Milestone Payment and any other payment due to former Kolltan stockholders under the Merger Agreement to be paid in shares of our common stock such that the transactions consummated by the Merger Agreement will satisfy the "continuity of interest" requirements set forth in Treasury Regulation Section 1.368-1(e) and other applicable law.

Need for Stockholder Approval

        Our common stock is listed on the NASDAQ Global Market, and we are subject to the NASDAQ listing standards set forth in its Marketplace Rules. Although we were not required to obtain stockholder approval in connection with the issuance of the Closing Merger Consideration because the shares of our common stock issued at Closing constituted less than 20% of our outstanding shares, we are required under Marketplace Rule 5635(a) to seek stockholder approval for the issuance of shares of common stock in connection with the Milestone Payments as further described below.

        NASDAQ Marketplace Rule 5635(a) requires stockholder approval prior to the issuance of securities in connection with the acquisition of the stock or assets of another company, including pursuant to an "earn-out" or similar provision, where due to the present or potential issuance of common stock (or securities convertible into or exercisable for common stock), other than a public offering for cash, the common stock to be issued (a) constitutes voting power in excess of 20% of the outstanding voting power prior to the issuance or (b) is or will be in excess of 20% of the outstanding common stock prior to the issuance. The shares issued as the Closing Merger Consideration did not constitute more than 20% of our total shares of common stock outstanding, so we were not required to obtain stockholder approval for the issuance of these shares. The Closing Merger Consideration constituted an amount of our common stock equivalent to approximately 18.5% of our outstanding common stock as of the November 1, 2016, the execution date of the Merger Agreement. The issuance of additional shares of common stock to former Kolltan stockholders in connection with the Milestone Payments would be aggregated with the shares we issued as Closing Merger Consideration for purposes of NASDAQ Marketplace Rule 5635(a). Accordingly, issuing additional shares of common stock as Milestone Payments to the former Kolltan stockholders may result in the aggregate number of shares issued by us in connection with the Kolltan Acquisition exceeding 20% of our total shares outstanding prior to the Kolltan Acquisition. Therefore, we are requesting stockholder approval for Proposal 3 under this NASDAQ listing standard to ensure that we have stockholder approval to issue shares of common stock as Milestone Payments to the extent that any such shares issued, when aggregated with shares previously issued in connection with the Kolltan Acquisition, exceed 20% of our common stock outstanding prior to the Kolltan Acquisition.

        Pursuant to the Merger Agreement, we agreed to seek stockholder approval at our stockholders meeting next following the execution of the Merger Agreement for the potential issuance of shares of our common stock pursuant to the Merger Agreement in excess of 19.99% of our outstanding shares.

        Pursuant to the Marketplace Rules of the NASDAQ Stock Market, the 18,257,996 shares issued to the former Kolltan securityholders and any part of the 437,901 shares issued to certain former Kolltan officers in lieu of cash severance obligations are not entitled to vote on this Proposal 3 and are not counted in determining votes cast for purposes of this Proposal 3.


Certain Consequences if Proposal 3 is Approved

        If this Proposal 3 is approved and we obtain stockholder authorization to issue in connection with the Kolltan Acquisition shares of common stock in excess of 20% of our outstanding shares, and (i) assuming all $172.5 million of Milestone Payments were to become payable, (ii) further assuming we elected to pay all such Milestone Payments in shares of our common stock, and (iii) further assuming a market price of $3.30, based on the closing price of our common stock on April 10, 2017, then, we would issue to the former stockholders of Kolltan in connection with such Milestone Payments an aggregate of 52,272,727 shares of our common stock, or approximately 42% of our outstanding shares as of April 10, 2017. The actual number of shares that may become issuable as Milestone Payments will depend on multiple factors including the Milestones that are actually achieved, the amount of the corresponding Milestone Payments that we elect to pay in shares of our common stock, and the market price of our common stock at the time that we pay the corresponding Milestone Payment in shares of our common stock. For purposes of the Milestone Payments, our common stock will be valued at the average of the closing sale prices per share of our common stock as reported on the NASDAQ (or other national exchange upon which our common stock is then listed) for the five (5) trading day period ending three (3) calendar days prior to the date such Milestone is achieved. While we believe that having the ability to pay Milestone Payments in shares of common stock offers benefits to the Company and its stockholders, including conservation of cash, the payment of Milestone Payments in shares of common stock may cause substantial dilution to the equity interest of our current stockholders.

Certain Consequences if Proposal 3 is Not Approved

        If this Proposal 3 is not approved by the stockholders, we would not be able to make Milestone Payments in shares of common stock to the extent Milestones are achieved because that would result in stock payments when aggregated with the shares issued as Closing Merger Consideration in excess of 20% of our outstanding shares prior to the Kolltan Acquisition. In such event, we would need to make the Milestone Payments in cash, in order to maintain compliance with applicable NASDAQ listing requirements. We expect we would need to raise additional financing if we decide to make the Milestone Payments in cash to the extent any Milestones are achieved.

        Furthermore, in the event this proposal is not approved, we intend to solicit such approval at next year's annual meeting.

Description of the Common Stock That May Be Issued In Connection With Milestone Payments

        The following summary description of the material features of our common stock is qualified in its entirety by reference to the applicable provisions of Delaware law, and also by reference to our amended and restated certificate of incorporation, as amended, our bylaws, and the instruments governing our securities that are exercisable for or convertible into shares of our common stock, which are on file with the Securities and Exchange Commission.

    General; Shares Outstanding

        Our common stock is listed on the NASDAQ Global Market under the trading symbol "CLDX". We are authorized to issue 297,000,000 shares of common stock pursuant to our amended and restated certificate of incorporation, as amended. As of April 10, 2017, there were 125,104,714 shares of our common stock outstanding. Additionally, on such date we had outstanding options to purchase an aggregate of 10,159,130 shares of our common stock at a weighted average exercise price of $11.11 per share. On April 10, 2017, the closing sale price of a share of our common stock as reported on NASDAQ was $3.30.


    Par Value

        The par value of our common stock is $0.001 per share.

    Dividends

        Our Board of Directors may, out of funds legally available, at any regular or special meeting, declare dividends to the holders of shares of our common stock as and when they deem expedient, subject to the rights of holders of the preferred stock, if any.

    Voting

        Each share of common stock entitles the holders to one vote per share on all matters requiring a vote of the stockholders, including the election of directors. No holders of shares of common stock shall have the right to vote such shares cumulatively in any election for the board of directors.

    Rights Upon Liquidation

        In the event of our voluntary or involuntary liquidation, dissolution, or winding up, the holders of our common stock will be entitled to share equally in our assets available for distribution after payment in full of all debts and after the holders of preferred stock, if any, have received their liquidation preferences in full.

    Miscellaneous

        No holders of shares of our common stock shall have any preemptive rights to subscribe for, purchase or receive any shares of any class, whether now or hereafter authorized, or any options or warrants to purchase any such shares, or any securities convertible into or exchanged for any such shares, which may at any time be issued, sold or offered for sale by us.

    Fully Paid and Nonassessable

        The shares of common stock that may be issued as in connection with the Milestone Payments will be fully paid and nonassessable.

    Holders

        As of April 10, 2017, there were approximately 350 holders of record of our common stock.

    Anti-Takeover Provisions

        Certain provisions in our third restated certificate of incorporation, as amended, and applicable Delaware corporate law may have the effect of discouraging a change of control of Celldex, even if such a transaction is favored by some of our stockholders and could result in stockholders receiving a substantial premium over the current market price of our shares. The primary purpose of these provisions is to encourage negotiations with our management by persons interested in acquiring control of our corporation. These provisions may also tend to perpetuate present management and make it difficult for stockholders owning less than a majority of the shares to be able to elect even a single director. Certain of these provisions are summarized below.

            Undesignated Preferred Stock.    The ability to authorize undesignated preferred stock makes it possible for our Board of Directors to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to acquire us. The ability to issue preferred stock may have the effect of deferring hostile takeovers or delaying changes in control or management of our company.


            Special Meetings.    Our bylaws provide that special meetings of the stockholders may, unless otherwise prescribed by law, only be called by the Chairman of the Board (if any), the President, the Secretary or by resolution of the directors.

        Computershare Trust Company, N.A. is presently the transfer agent and registrar for our common stock.

Resale Limitations

        The offer and sale of the shares of our common stock issued or to be issued pursuant to the Merger Agreement (including the Closing Merger Consideration and any Milestone Payments that become payable in the future which we elect to pay in shares) has been made in a private placement in reliance upon the exemption from registration provided by Section 4(a)(2) of the Securities Act of 1933, as amended (the "Securities Act"), for transactions by an issuer not involving a public offering, and Regulation D under the Securities Act. All certificates evidencing shares of our common stock issued or issuable in connection with the Kolltan Acquisition bore or will bear, as applicable, a standard restrictive legend under the Securities Act. Any shares of our common stock issued in connection with the Kolltan Acquisition may not be sold or transferred unless registered under the Securities Act or unless an exemption from registration is available.

Registration Rights

        Under the terms of the Merger Agreement, we agreed to file with the Securities and Exchange Commission, as promptly as practical following the Closing Date, but in any event not later than sixty (60) following the Closing Date, a registration statement covering the resale of the shares of our common stock issued at Closing and to use reasonable efforts to cause such registration statement to be declared effective as soon as reasonably practicable after filing. In January 2017, we filed a registration statement on Form S-3 covering the registration of 18,369,107 shares issued in connection with the Kolltan Acquisition and such registration statement was declared effective February 13, 2017. We further agreed to use reasonable best efforts to maintain the continuous effectiveness of such registration statement until the earlier of (i) the date all such registration shares have been sold pursuant to such registration statement, or (ii) such time as all such registration shares may be sold under Rule 144 of the Securities Act. We also agreed, if any shares are issued as part of a Milestone Payment to file registration statements covering the resale of such shares of our common stock, if any, as promptly as practical, but in any event not later than forty-five (45) days following issuance of any such shares. We agreed to pay all expenses associated with the preparation and filing of such registration statements and any amendments or supplements thereto, and any actions or filings necessary to maintain the effectiveness of such registration statements.

Interests of Certain Persons in the Proposal and Past Contacts

        In connection with the Kolltan Acquisition, Theresa LaVallee, Ph.D. (Kolltan's Senior Vice President, Translational Medicine prior to the Kolltan Acquisition) entered into an employment agreement with us on November 29, 2016, and was appointed as our Senior Vice President, Regulatory and Precision Medicine. Dr. LaVallee's employment agreement provided for, among other things, an annual base salary of $322,400, eligibility for an annual bonus having a target of 35% of her then base salary and certain severance payments if her employment was terminated "without cause" or she resigned "for good reason" (as defined in her employment agreement). Dr. LaVallee has informed Celldex of her decision to relocate to the West Coast to be closer to family and, as such, has provided notice of her resignation which will be effective during the second quarter of 2017.

        On December 14, 2016, we appointed Gerald McMahon, Ph.D., who served as President, Chief Executive Officer and member of the board of directors of Kolltan prior to the Kolltan Acquisition.


Previously, on November 28, 2016, in connection with Dr. McMahon's employment separation with Kolltan Pharmaceuticals, Inc., we entered into a severance agreement with Dr. McMahon whereby we agreed to pay Dr. McMahon up to 267,356 shares of our common stock less required tax and other withholdings. To date, 64,667 shares of common stock were issued to Dr. McMahon, 35,796 shares have been withheld to satisfy tax withholdings and the shareholders of Celldex and Celldex became a wholly-owned subsidiary of the Company. The Merger was accounted for using the purchase method of accounting and was treated as an acquisition by Celldex of the Company with Celldex being considered the accounting acquirer based on the application of criteria specified in Statement of Financial Accounting Standards (“SFAS”) No. 141, Business Combination, (“SFAS 141”), even though the Company was the issuerremaining 166,893 shares of common stock, andless applicable withholdings, are issuable to Dr. McMahon in equal monthly installments through December 2018.

        The other former stockholders of Kolltan also have an interest in this Proposal 3 insofar as approval of the surviving legal entity in the transaction. Because Celldex was determinedproposal would enable them to be the acquirerpaid any Milestone Payments as become due in shares of our common stock.

Vote Required for accounting purposes, the historical financial statements of Celldex became the historical financial statementsApproval; Effectiveness

        The affirmative vote of the combined company asholders of a majority of the closingtotal votes cast in person or by proxy at the Annual Meeting will be required to approve the issuance of shares of our common stock in connection with the Milestone Payments. Abstentions and broker non-votes will not be counted as votes cast and therefore will not affect the determination as to whether this Proposal 3 is approved. Pursuant to the Marketplace Rules of the Merger.

-35-


     Celldex’s financial statements for 2006NASDAQ Stock Market, however, the 18,257,996 shares issued to the former Kolltan securityholders and 2007 were audited by Ernst & Young LLP (“E&Y”). Since 1994, the Company’s financial statements were audited by PricewaterhouseCoopers (“PwC”). As of March 7, 2008, the effective dateany part of the Merger, the Audit Committee437,901 shares issuable to certain former officers of the Company authorized PwCKolltan that have already been issued are not entitled to continue as the Company’s independent accountantsvote on this Proposal 3 and are not counted in determining votes cast for 2008. The Staffpurposes of the Securities and Exchange Commission takes the position that in a transaction such as the Merger, there is always a change of independent accountants (unless the same firm had served as the independent accountants of both the acquiring and the acquired companies). Accordingly, the Company filed a Current Report on Form 8-K on June 9, 2008 to report that when the Company’s Audit Committee authorized PwC continue as the Company’s independent accountants, as a technical matter that authorization resulted in E&Y being “dismissed” as Celldex’s independent accountants.this Proposal 3.

     During the past two years, E&Y’s report on the financial statements of Celldex did not contain an adverse opinion or disclaimer of opinion, was not qualified or modified as to uncertainty, audit scope or accounting principles.

     During the two fiscal years preceding the “dismissal” of E&Y:

  •      There were no disagreements between Celldex or the Company and E&Y on anymatter of accounting principles or practices, financial statement disclosure, or auditingscope or procedure, which disagreement(s), if not resolved to the satisfaction of E&Y,would have caused it to make reference to the subject matter of the disagreement(s) inconnection with its report.
  •      None of the “reportable events” listed in paragraphs (a)(1)(v)(A) through (D) ofItem 304 of Regulation S-K promulgated by the Securities and Exchange Commission(“Item 304”) occurred, except as set forth below.
    • Response to paragraph (a)(1)(v)(A) of Item 304- On May 7, 2008, E&Yreported to the Company’s management and Audit Committee that it had notedthe following material weaknesses in Celldex’s internal control over financialreporting: (i) during 2007, Celldex did not maintain an effective segregation ofduties (specifically, certain authority and responsibility were not appropriatelyassigned and delegated to employees within the organization); and (ii) during2007, Celldex did not maintain effective internal control over the financialstatement closing process (specifically, Celldex did not maintain formal, writtenpolicies and procedures governing the financial close and reporting process toensure an accurate and timely financial statement closing process). The latter control deficiency resulted in misstatements to general and administrative expense, research and development expense and accrued liability accounts and related financial statement disclosures. Management of the Company had already noted those material weaknesses as of March 31, 2008, and there was no disagreement with E&Y concerning these matters. These material weaknesses were discussed with the Company’s Audit Committee. The Company has authorized E&Y to respond fully to the inquiries of the successor accountant with respect to these matters, without limitations.

-36-


     The Company provided E&Y with a copy of the disclosures that the Company is making herein in response to Item 304 and requested that E&Y furnish to the Company a letter addressed to the Securities and Exchange Commission stating whether it agrees with the statements made by the Company in response to Item 304 and, if not, stating the respects in which it does not agree. The Company filed the letter received from E&Y in response to that request as an exhibit to the Current Report on Form 8-K filed with the Commission on June 9, 2008.

     As discussed above, when the Company’s Audit Committee authorized PwC to continue as the Company’s independent accountants, PwC became engaged as the Company’s independent registered public accounting firm as of March 7, 2008. During the two most recent fiscal years and through March 7, 2008, Celldex had not consulted with PwC regarding either (i) the application of accounting principles to a specified transaction, either completed or proposed; or the type of audit opinion that might be rendered on Celldex’s financial statements, and neither a written report was provided to Celldex nor oral advice was provided that PwC concluded was an important factor considered by Celldex in reaching a decision as to the accounting, auditing or financial reporting issue; or (ii) any matter that was either the subject of a disagreement, as that term is defined in Item 304(a)(1)(iv) of Regulation S-K and the related instructions to Item 304 of Regulation S-K, or a reportable event, as that term is defined in Item 304(a)(1)(v) of Regulation S-K.

THE BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE
FOR "FOR" THE RATIFICATIONAPPROVAL, IN ACCORDANCE WITH THE APPLICABLE RULES OF THE INDEPDENT REGISTERED PUBLICNASDAQ STOCK MARKET, OF THE ISSUANCE OF SHARES OF OUR COMMON STOCK IN CONNECTION WITH MILESTONE PAYMENTS THAT MAY BECOME PAYABLE IN THE FUTURE TO FORMER SECURITYHOLDERS OF KOLLTAN PHARMACEUTICALS, INC.



ACCOUNTING FIRM

PROPOSAL 3: AMEND4: APPROVE THE AMENDMENT TO THE
CERTIFICATE OF INCORPORATION

2008 STOCK OPTION AND INCENTIVE PLAN

(Proposal No. 3)4)

        On July 17, 2008, our Board of Directors adopted, subjectStockholders are requested in this Proposal 4 to stockholder approval,approve an amendment to our Certificate2008 Stock Option and Incentive Plan as amended and restated effective as of IncorporationJune 10, 2015 (the "2008 Plan") to changeincrease the namenumber of shares reserved for issuance thereunder by 5,650,000 to 20,000,000 shares. The general purpose of our 2008 Plan is to provide a means whereby eligible employees, officers, non-employee directors and other individual service providers develop a sense of proprietorship and personal involvement in the development and financial success of the Company from “AVANT Immunotherapeutics, Inc.”and to “Celldex Therapeutics, Inc.” A copyencourage them to devote their best efforts to the business of the Certificate of Amendment is attached hereto as Annexure A. The Board of Directors determined that, due to strategic considerations, it is inCompany, thereby advancing the best interestinterests of the Company and its stockholdersstockholders. Our Board believes that the 2008 Plan advances our interests by enhancing our ability to re-brand(i) attract and retain employees, officers, non-employee directors and other individual service providers, (ii) provide incentives for such persons to exert maximum efforts for the businesssuccess of the Company and its subsidiaries, and (iii) reward such persons for these efforts.

        On March 1, 2017, the Board of Directors approved an amendment to the 2008 Plan, subject to approval at this Annual Meeting by our stockholders, to increase the number of shares reserved for issuance thereunder by 5,650,000 to 20,000,000 shares.

        The Board of Directors believes that the approval of the amendment to the 2008 Plan is important to our continued success. In particular, the Board of Directors believes that our employees are our most valuable assets and that the awards permitted under the name “Celldex Therapeutics, Inc.”2008 Plan are vital to our ability to attract and retain outstanding and highly skilled individuals in the extremely competitive labor markets in which we operate. Such awards also are crucial to our ability to motivate our employees to achieve our goals. The amendment to our 2008 Plan is intended to ensure that we have sufficient shares reserved for issuance under the 2008 Plan to provide incentives to our participant base. We expect that we will use approximately 2,000,000 to 2,500,000 shares each year to issue equity awards to attract new hires and retain existing employees. We are asking to increase the option pool so that we have sufficient shares available new and existing employees and independent contractors for the next three years.

-37-        Immediately below is a summary of the 2008 Plan and a discussion of the federal income tax consequences of the issuance and exercise of incentives under the 2008 Plan to recipients and to us. This summary of the 2008 Plan is qualified entirely by reference to the complete text of the 2008 Plan, a copy of which is attached to this proxy statement asAnnexure A.


Description of the 2008 Plan

        The ticker symbol2008 Plan may be administered by the Board of Directors, or the compensation committee or similar committee of the Company (AVAN)Board of Directors (the "administrator"). The administrator, at its discretion, may grant a variety of stock incentive awards based on our Common Stock. Awards under the 2008 Plan include stock options (both incentive options and non-qualified options), stock appreciation rights, restricted stock, deferred stock, cash-based awards, performance shares, unrestricted stock and dividend equivalent rights. These awards are described in greater detail below.

        The maximum number of shares of Common Stock that can be issued under the 2008 Plan is expected14,350,000 shares of which no more than 500,000 shares will be available for grants in the form of restricted stock, deferred stock, performance shares or unrestricted stock. Based solely upon the closing price of the Common Stock as reported by NASDAQ on April 10, 2017, the maximum aggregate market value of the securities to changebe issued under the 2008 Plan would be $47.4 million. If this amendment is approved, the maximum number of shares of Common Stock issuable under the 2008 Plan will increase from 14,350,000 shares to 20,000,000 shares. For years, we have successfully used


stock options to attract, retain and motivate employees in a highly competitive marketplace. Option grants have been given to a broad base of employees and Named Executive Officers. We believe that our stock option program has been very successful over the years in motivating our employees while enhancing shareholder value and therefore it is very valuable to us that we be able to continue offering option grants.

        The shares issued by Celldex under the 2008 Plan may be authorized but unissued shares, or shares reacquired by Celldex (subject to the limitation set forth below). For purposes of determining the aggregate number of shares of common stock that may be issued under the 2008 Plan, the following shares will be counted as issued and, therefore, may not be made subject to new awards under the 2008 Plan:

    shares of common stock repurchased by us with option proceeds;

    shares of common stock that are tendered (by either actual delivery or attestation) or withheld to either pay the exercise price of a stock option granted under the 2008 Plan or to satisfy tax withholding obligations associated with an award granted under the 2008 Plan; and

    shares of common stock that are covered by stock appreciation rights to the extent that such stock appreciation rights are exercised and settled in shares of common stock, whether or not shares of common stock are actually issued to the grantee upon such exercise.

        To ensure that certain awards under the 2008 Plan, including restricted stock, deferred stock, cash-based awards and performance shares, qualify as "performance-based compensation" under Section 162(m) of the Internal Revenue Code of 1986, as amended (the "Code"), the 2008 Plan provides that the administrator may require that vesting or grants of such awards be conditioned on the satisfaction of performance criteria that may include any of the following: (i) our return on equity, assets, capital or investment, (ii) our pre-tax or after-tax profit levels or that of any subsidiary, division, operating unit or business segment, or any combination of the foregoing; (iii) cash flow, funds from operations, year-end cash and equivalents balance or similar measure; (iv) total shareholder return; (v) changes in the market price of our stock; (vi) sales or market share; (vii) earnings per share; (viii) partnerships, collaborations, joint ventures, alliances and similar arrangements involving us; (ix) mergers, acquisitions and business combinations of or by us; or (x) our rights to intellectual property and scientific discoveries. The administrator will select the particular performance criteria within 90 days following the commencement of a performance cycle (or, if shorter, within the maximum period allowed under Section 162(m) of the Code). Subject to adjustments for stock splits and similar events, for awards intended to qualify for the exception for "qualified performance-based compensation" under Section 162(m) of the Code, it will limit the number of shares payable to any one participant in respect of any one calendar year with respect to restricted stock awards, deferred stock awards or performance share awards to 250,000 shares in the aggregate, and will further limit the dollar value payable to any one participant in respect of any one calendar year on awards denominated in cash to $1,000,000. For stock options or stock appreciation rights, no more than 2,000,000 shares may be granted to any one individual during any calendar year period.

        Plan Administration.    The 2008 Plan is administered by our Board of Directors or by the compensation committee or a similar committee of the Board of Directors. The administrator of the 2008 Plan has full power and authority to select the participants to whom awards will be granted, to make any combination of awards to participants, to accelerate the exercisability or vesting of an award only upon a grantee's death, a grantee's "disability" (as defined in the 2008 Plan) or a "change of control" (as defined in the 2008 Plan) or "sale event" (as defined in the 2008 Plan) and to determine the specific terms and conditions of each award, subject to the provisions of the 2008 Plan. The administrator may delegate to the Chief Executive Officer the authority to grant awards to individuals who are not subject to the reporting and other provisions of Section 16 of the Securities Exchange Act of 1934, as amended, and are not Covered Employees, provided that the administrator fixes the


maximum number of shares that may be awarded and provides specific guidelines regarding such awards.

        Eligibility and Limitations on Grants.    All full-time and part-time officers, employees, non-employee directors and other key persons are eligible to participate in the 2008 Plan, subject to the discretion of the administrator.

        Stock Options.    The exercise price of stock options awarded under the 2008 Plan may not be less than the fair market value of the Common Stock on the date of the option grant, except that for a grant of an incentive stock option to any employee who is an owner of more than 10 percent of the voting power of Celldex, the exercise price of stock options awarded under the 2008 Plan may not be less than 110% of the fair market value of the Common Stock on the date of the option grant. The term of each stock option may not exceed 10 years from the date of grant, except that for a grant of an incentive stock option to any employee who is an owner of more than 10 percent of the voting power of Celldex the term of each stock option may not exceed 5 years from the date of grant. The administrator will determine at what time or times each option may be exercised.

        Stock Appreciation Rights.    The administrator may award a stock appreciation right either as a resultfreestanding award or in tandem with a stock option. The administrator may award stock appreciation rights subject to such conditions and restrictions as the administrator may determine.

        Restricted Stock.    The administrator may award shares to participants subject to such conditions and restrictions as the administrator may determine. These conditions and restrictions may include the achievement of certain performance goals and/or continued employment with Celldex through a specified restricted period.

        Deferred Stock.    The administrator may award deferred stock units to participants subject to such conditions and restrictions as the administrator may determine. These conditions and restrictions may include the achievement of certain performance goals and/or continued employment with Celldex through a specified restricted period. At the end of the proposed name change. Wedeferral period, the participants shall be paid, to the extent vested, in shares.

        Unrestricted Stock.    The administrator may grant (or sell at par value or for a higher purchase price determined by the Administrator) shares that are free from any restrictions under the 2008 Plan. Unrestricted stock may be issued to participants in recognition of past services or other valid consideration, and may be issued in lieu of cash compensation to be paid to such individuals.

        Cash-Based Awards.    The administrator may in its discretion grant awards entitling the grantee to receive cash-denominated payments and determine the terms and conditions of the cash-based award. Each cash-based award will publicly announcespecify a cash-denominated payment amount, formula or payment ranges as determined by the new ticker symbol atadministrator. Payment with respect to a cash-based award may be made in cash or stock, as the administrator determines.

        Performance Shares.    The administrator may grant performance share awards that entitle the recipient to acquire shares of Common Stock upon the attainment of specified performance goals. The administrator determines the performance goals, performance periods and other terms of any such awards.

        Dividend Equivalent Rights.    The administrator may award a dividend equivalent right either as a freestanding award or in tandem with another award under the 2008 Plan. The administrator may award dividend equivalent rights subject to such conditions and restrictions as the administrator may determine. Dividend equivalents credited to the holder may be paid currently or may be deemed to be reinvested in additional shares of stock, which may thereafter accrue additional equivalents.


        Tax Withholding.    Participants in the 2008 Plan are responsible for the payment of any federal, state or local taxes that the Company is required by law to withhold upon any option exercise or vesting of other awards. Subject to approval by the administrator, participants may elect to have the minimum tax withholding obligations satisfied either by authorizing the Company to withhold shares to be issued pursuant to an option exercise or other award, or by transferring to the Company shares having a value equal to the amount of such taxes.

        Change of Control Provisions.    Upon the occurrence of a "change in control" (as defined in the 2008 Plan), all outstanding stock options, stock appreciation rights and dividend equivalent rights will not automatically become fully exercisable and all other outstanding awards with conditions and restrictions relating solely to the passage of time as we receive it.

     Stockholdersand continued employment or service will not be fully vested, if provision is made in connection with the change of control for the assumption or continuation by the successor entity of such outstanding equity awards, or the substitution of such outstanding awards with new awards of the successor entity or parent thereof, with appropriate adjustment as to the number and kind of shares and, if appropriate, the per share exercise prices, as such parties shall agree.

        Amendments and Termination.    The 2008 Plan is available for the grant of new awards until June 9, 2025 (or April 16, 2025 with respect to incentive stock options). In addition, the board of directors may amend or discontinue the 2008 Plan at any time, and the administrator may amend or cancel any outstanding award for the purpose of satisfying changes in law or for any other lawful purpose. No such amendment may adversely affect the rights under any outstanding award without the holder's consent. Except in connection with a merger, consolidation, reorganization, recapitalization, reclassification, stock dividend, stock split or other similar transaction or change in our capital stock, the administrator may not, without obtaining stockholder approval, reprice or otherwise reduce the exercise price of outstanding stock options or stock appreciation rights or cancel outstanding options with an exercise price above the current stock price in exchange for cash or securities. Additionally, stockholder approval will be required to submit theiramend the 2008 Plan if the administrator determines that this approval is required to ensure that incentive stock certificatesoptions qualify as such under the Code, or that compensation earned under awards qualifies as performance-based compensation under the Code or as required under the applicable securities exchange or market system rules.

Tax Aspects Under the Code

        The following is a summary of the principal federal income tax consequences of certain transactions under the 2008 Plan. It does not describe all federal tax consequences under the 2008 Plan, nor does it describe state or local tax consequences.

        Incentive Options.    No taxable income is generally realized by the optionee upon the grant or exercise of an incentive option. If shares issued to an optionee pursuant to the exercise of an incentive option are sold or transferred after two years from the date of grant and after one year from the date of exercise, then (i) upon sale of such shares, any amount realized in excess of the option price (the amount paid for exchangethe shares) will be taxed to the optionee as a long-term capital gain, and any loss sustained will be a long-term capital loss, and (ii) there will be no deduction for the Company for federal income tax purposes. The exercise of an incentive option will give rise to an item of tax preference that may result in alternative minimum tax liability for the optionee.

        If shares acquired upon the exercise of this proposed name change. Followingan incentive option are disposed of prior to the effective dateexpiration of the amendment changingtwo-year and one-year holding periods described above (a "disqualifying disposition"), generally (i) the Company’s name, all new stock certificates issued byoptionee will realize ordinary income in the year of disposition in an amount equal to the excess (if any) of the fair market value of the shares at exercise (or, if less, the amount realized on a sale of such shares) over the option price thereof, and (ii) the Company will be overprinted withentitled to deduct such


amount. Special rules will apply where all or a portion of the Company’s new name.exercise price of the incentive option is paid by tendering shares.

        If stockholders approvean incentive option is exercised at a time when it no longer qualifies for the proposaltax treatment described above (e.g., if the holding periods described above are not satisfied), the option is treated as a non-qualified option. In addition, an incentive option will not be eligible for the tax treatment described above if it is exercised more than three months following termination of employment (or one year in the case of termination of employment by reason of disability). In the case of termination of employment by reason of death, the three-month rule does not apply.

        Non-Qualified Options.    No income is realized by the optionee at the time the option is granted. Generally (i) at exercise, ordinary income is realized by the optionee in an amount equal to the difference between the option price and the fair market value of the shares on the date of exercise, and the Company receives a tax deduction for the same amount, and (ii) at disposition, appreciation or depreciation after the date of exercise is treated as either short-term or long-term capital gain or loss depending on how long the shares have been held. Special rules will apply where all or a portion of the exercise price of the non-qualified option is paid by tendering shares. Upon exercise, the optionee will also be subject to Social Security taxes on the excess of the fair market value over the exercise price of the option.

Parachute Payments

        The vesting of any portion of an option or other award that is accelerated due to the occurrence of a change in control may cause a portion of the payments with respect to such accelerated awards to be treated as "parachute payments" as defined in Section 280G of the Code. Any such parachute payments may be non-deductible to the Company, in whole or in part, and may subject the recipient to a non-deductible 20% federal excise tax on all or a portion of such payment (in addition to other taxes ordinarily payable).

Limitation on the Company's Deductions

        As a result of Section 162(m) of the Code, the Company's deduction for certain awards under the 2008 Plan may be limited to the extent that the Chief Executive Officer or other executive officer whose compensation is required to be reported in the summary compensation table receives compensation in excess of $1 million a year (other than performance-based compensation that otherwise meets the requirements of Section 162(m) of the Code). The 2008 Plan is structured to allow grants to qualify as performance-based compensation.

Equity Compensation Plan Information

        The following table provides information as of December 31, 2016 regarding shares of our common stock that may be issued under our existing equity compensation plans, including our 2008


Stock Option and Incentive Plan (the "2008 Plan") and our 2004 Employee Stock Purchase Plan (the "2004 ESPP Plan").

 
 Equity Compensation Plan Information 
 
 Number of securities
to be issued upon exercise
of outstanding options
and rights(1)
 Weighted average
exercise price of
outstanding options
and rights
 Number of securities
remaining available for
future issuance under equity
compensation plan
(excluding securities
referenced in column (a))
 

Equity compensation plans approved by security holders(2)

  10,218,710(3)$11.14  3,655,871(4)

(1)
Does not include any Restricted Stock as such shares are already reflected in our outstanding shares.

(2)
Consists of the 2008 Plan, 2004 ESPP Plan and Celldex Research's 2005 Equity Incentive Plan.

(3)
Does not include purchase rights accruing under the 2004 ESPP Plan because the purchase price (and therefore the number of shares to be purchased) will not be determined until the end of the purchase period.

(4)
Includes shares available for future issuance under the 2008 Plan and the 2004 ESPP Plan of which 302,660 shares are available for grants in the form of restricted stock, deferred stock, performance shares or unrestricted stock under the 2008 Plan.

New Plan Benefits

        Incentive awards under the 2008 Plan are subject to the discretion of the Compensation Committee. Therefore, it is generally not possible to determine the incentives awards that will be granted or awarded under the 2008 Plan in the future to any person or the incentive awards that would have been granted or awarded if this amendment to our 2008 Plan had been in effect in the year ended December 31, 2016. However, irrespective of whether the amendment to our 2008 Plan is approved, we expect to issue restricted stock and options to each of our non-employee directors following the Annual Meeting in accordance with our non-employee director compensation policy, which is described in more detail in the section titled "Director Compensation." Furthermore, information about awards granted in 2016 to our Named Executive Officers can be found in the table under the heading "Grants of Plan-Based Awards" in the section titled "Executive Compensation."

Vote Required

        The affirmative vote of the holders of a majority of the votes cast in person or by proxy at the Annual Meeting will be required to approve the Company will implementamendment to the name change on or about September 25, 2008.2008 Plan to increase the shares of common stock reserved for issuance thereunder by 5,650,000 to 20,000,000 shares.

THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE “FOR”"FOR" APPROVAL OF THE CERTIFICATEAMENDMENT TO OUR 2008 STOCK OPTION AND INCENTIVE PLAN.



PROPOSAL 5: APPROVAL OF AMENDMENT.AN AMENDMENT TO THE
2004 EMPLOYEE STOCK PURCHASE PLAN

(Proposal No. 5)

        Stockholders are requested in this Proposal 5 to approve an amendment to our 2004 Employee Stock Purchase Plan (the "2004 Plan") to increase the number of shares of our common stock reserved for issuance thereunder from 200,000 shares to 400,000 shares, which was adopted by the Board of Directors on March 1, 2017, subject to the approval by our stockholders. Over the past several years, we have expanded our employee base. Approval of the amendment to the 2004 Plan is intended to ensure that we have sufficient shares reserved for issuance under the 2004 Plan to provide incentives to our expanded participant base.

        Immediately below is a summary of the existing 2004 Plan and a discussion of the federal income tax consequences of the issuance and exercise of options to purchase shares of our common stock under the 2004 Plan to recipients and to us. This summary of the existing 2004 Plan is qualified entirely by reference to the complete text of the 2004 Plan, a copy of which is attached to this proxy statement asAnnexure B.

Description of the Existing 2004 Plan

        The 2004 Plan was approved by our stockholders on May 13, 2004 and has subsequently been amended such that 200,000 shares of our common stock are reserved for issuance thereunder. The closing price of our common stock as reported by the NASDAQ Global Market on April 10, 2017 was $3.30.

        Under the 2004 Plan, eligible employees may authorize Celldex to deduct amounts from their pay, which amounts are used to enable the employees to purchase shares of Celldex common stock. The 2004 Plan is intended to be an "employee stock purchase plan" under Section 423(b) of the Internal Revenue Code of 1986, as amended, (the "Code").

        The 2004 Plan is administered by Celldex's Board of Directors or a person or persons appointed by the Board of Directors for such purpose. The 2004 Plan provides that all employees of Celldex and certain of its subsidiaries whose customary employment is for more than 20 hours per week and more than five months in any calendar year are eligible to participate in the 2004 Plan following sixty days of active employment, provided, however, that persons who are deemed under Section 423(b) of the Code to own five percent (5%) or more of Celldex's voting stock are excluded from participation. As of December 31, 2016, approximately 207 employees were eligible to participate in the 2004 Plan, of whom 17% enrolled in the 2004 Plan for the purchase period beginning January 1, 2017.

        The 2004 Plan provides for two purchase periods each year, the first commencing on January 1 of each year and continuing through June 30 of such year, and the second commencing on July 1 of each year and continuing through December 31 of such year. Eligible employees may elect to become participants in the 2004 Plan by enrolling prior to each semi-annual purchase period. Shares are purchased through the accumulation of payroll deductions of not less than one percent (1%) nor more than fifteen percent (15%) of each participant's compensation. No employee may be granted an option under the 2004 Plan which permits the right to purchase shares of common stock at a rate that exceeds $25,000 (determined on the date of grant) for each calendar year the option is outstanding. The number of shares to be purchased is determined by dividing the participant's balance in the plan account on the last day of the purchase period by the purchase price per share for the stock. The purchase price per share will be the lower of 85% of the fair market value of the common stock as of either the beginning or ending date of the semi-annual purchase period of shares for the participant's account.


        An option granted under the 2004 Plan is not transferable by the participant except by will or by the laws of descent and distribution. Employees may cease their participation in the offering at any time during a purchase period, and participation automatically ceases on termination of employment.

        The number of shares that are reserved for issuance under the 2004 Plan is subject to adjustment for stock splits and similar events. The proceeds received by Celldex from exercise under the 2004 Plan will be used for the general purposes of Celldex. Shares issued under the 2004 Plan may be from authorized but unissued shares or shares reacquired by Celldex and held in its treasury, or any other proper source.

        The 2004 Plan shall remain in full force and effect until suspended or discontinued by the Board of Directors. The Board of Directors may amend the 2004 Plan at any time and for any purposes permitted by law, and may terminate the 2004 Plan at any time. Any amendment to the 2004 Plan that increases the number of shares available under the 2004 Plan and certain other amendments that are required to be approved by stockholders to comply with Section 423(b) of the Code must be approved by stockholders.

Federal Income Tax Considerations Under the 2004 Plan

        The following is a summary of the federal income tax consequences resulting from the issuance and exercise of options to purchase shares of common stock under the 2004 Plan:

        The 2004 Plan is intended to qualify as an "employee stock purchase plan" as defined in Section 423(b) of the Code. As a result, an employee will not recognize income for federal income tax purposes at the time of the transfer of shares of common stock to the employee pursuant to the exercise of an option granted under the 2004 Plan.

        If shares acquired under the 2004 Plan are sold more than two years after the first day of the purchase period pursuant to which the shares were purchased, no taxable income results if the proceeds of the sale are equal to or less than the price paid for the shares. If the proceeds of the sale are higher than the purchase price, the employee will recognize ordinary income for the year in which the sale occurs equal to the lesser of (i) fifteen percent (15%) of the fair market value of the common stock on the first day of the purchase period pursuant to which the shares were purchased or (ii) the excess of the amount actually received for the shares over the amount paid. In addition, the employee may recognize long-term capital gain or loss in an amount equal to the difference between the proceeds of the sale and the employee's basis in the shares (i.e., the employee's purchase price plus the amount taxed to the employee as ordinary income). No deduction is allowed to the company.

        If shares acquired under the 2004 Plan are sold within two (2) years of the first day of the purchase period pursuant to which the shares were purchased, the employee will recognize ordinary income equal to the difference between the fair market value of the shares on the exercise date and the employee's purchase price. This amount is reportable as ordinary income even if no profit was realized on the sale of shares or the shares were sold at a loss. Long-term or short-term (depending on the holding period for the shares) capital gain or loss will be recognized in an amount equal to the difference between the proceeds of sale and the employee's basis in the shares (i.e., the employee's purchase price plus the amount taxed to the employee as ordinary income). The amount reportable as ordinary income from a sale made within two years of the first day of the purchase period pursuant to which the shares were purchased will generally be allowed as a tax deduction to the company.

Equity Compensation Plan Information

        The following table provides information as of December 31, 2016 regarding shares of our common stock that may be issued under our existing equity compensation plans, including our 2008


Stock Option and Incentive Plan (the "2008 Plan") and our 2004 Employee Stock Purchase Plan (the "2004 ESPP Plan").

 
 Equity Compensation Plan Information 
 
 Number of securities
to be issued upon
exercise of
outstanding options
and rights(1)
 Weighted average
exercise price of
outstanding options
and rights
 Number of securities
remaining available
for future issuance
under equity
compensation plan
(excluding securities
referenced in
column (a))
 

Equity compensation plans approved by security holders(2)

  10,218,710(3)$11.14  3,655,871(4)

(1)
Does not include any Restricted Stock as such shares are already reflected in our outstanding shares.

(2)
Consists of the 2008 Plan, 2004 ESPP Plan and Celldex Research's 2005 Equity Incentive Plan.

(3)
Does not include purchase rights accruing under the 2004 ESPP Plan because the purchase price (and therefore the number of shares to be purchased) will not be determined until the end of the purchase period.

(4)
Includes shares available for future issuance under the 2008 Plan and the 2004 ESPP Plan of which 302,660 shares are available for grants in the form of restricted stock, deferred stock, performance shares or unrestricted stock under the 2008 Plan.

New Plan Benefits

        Future benefits available under the 2004 Plan are subject to the participation level of our employees and to our stock price at the time of any purchases and are, therefore, not determinable at this time.

Vote Required

        The affirmative vote of the holders of a majority of the votes cast in person or by proxy at the Annual Meeting will be required to approve the amendment to the 2004 Plan to increase the shares of common stock reserved for issuance thereunder to 400,000.

THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" APPROVAL OF THE AMENDMENT TO OUR 2004 EMPLOYEE STOCK PURCHASE PLAN.



PROPOSAL 6: ADVISORY VOTE ON EXECUTIVE COMPENSATION

(Proposal No. 6)

        Under the Dodd-Frank Wall Street Reform and Consumer Protection Act, or the Dodd-Frank Act, and Section 14A of the Securities Exchange Act of 1934, as amended, or the Exchange Act, our stockholders are entitled to vote to approve, on an advisory (nonbinding) basis, the compensation of our Named Executive Officers as disclosed in this proxy statement in accordance with the Securities and Exchange Commission's rules.

        As described in detail under the heading "Compensation of Executive Officers—Compensation Discussion and Analysis," our executive compensation programs are designed to retain and incentivize the high quality executives whose efforts are key to our long-term success. Under these programs, our Named Executive Officers are rewarded on the basis of individual and corporate performance measured against established corporate and strategic goals. Please read the section of this proxy statement under the heading "Compensation of Executive Officers—Compensation Discussion and Analysis" for additional details about our executive compensation programs, including information about the fiscal year 2016 compensation of our Named Executive Officers.

        The Compensation Committee of our Board of Directors continually reviews the compensation programs for our Named Executive Officers to ensure they achieve the desired goals of aligning our executive compensation structure with our stockholders' interests and current market practices.

        We are asking our stockholders to indicate their support for our Named Executive Officer compensation as described in this proxy statement. This proposal, commonly known as a "say-on-pay" proposal, gives our stockholders the opportunity to express their views on our Named Executive Officers' compensation. This vote is not intended to address any specific item of compensation, but rather the overall compensation of our Named Executive Officers and the philosophy, policies and practices described in this proxy statement. Accordingly, we are asking our stockholders to cast a non-binding advisory vote "FOR" the following resolution at the Annual Meeting:

            "RESOLVED, that the compensation of the Named Executive Officers, as disclosed in the Company's Proxy Statement for the 2017 Annual Meeting of Stockholders pursuant to Item 402 of Regulation S-K, including the Compensation Discussion and Analysis, compensation tables and narrative disclosure is hereby APPROVED."

        The say-on-pay vote is advisory, and therefore not binding on Celldex Therapeutics, the Compensation Committee or our Board of Directors. Nevertheless, our Board of Directors and our Compensation Committee value the opinions of our stockholders, whether expressed through this vote or otherwise, and accordingly, the Board and Compensation Committee intend to consider the results of this vote among the many factors they consider in making determinations in the future regarding executive compensation arrangements.

        Stockholder approval of this Proposal No. 6 will require the affirmative vote of the holders of a majority of the votes cast in person or by proxy at the Annual Meeting.

THE BOARD RECOMMENDS A VOTE FOR THIS PROPOSAL NO. 6



PROPOSAL 7: ADVISORY VOTE ON THE FREQUENCY OF STOCKHOLDER ADVISORY VOTES ON EXECUTIVE COMPENSATION

(Proposal No. 7)

        The Dodd-Frank Act and Section 14A of the Exchange Act also enables our stockholders to indicate their preference regarding how frequently we should seek non-binding advisory votes on the compensation of our Named Executive Officers, as disclosed in our proxy statements pursuant to the SEC's compensation disclosure rules. By voting on this Proposal No. 7, stockholders may indicate whether they would prefer an advisory vote on the compensation of our Named Executive Officers once every one, two, or three years. Alternatively, stockholders may abstain from casting a vote.

        Since 2011, we have sought an advisory vote on executive compensation at each annual meeting of our stockholders. After careful consideration of this proposal, our Board of Directors has determined that an advisory vote on executive compensation that occurs every year continues to be the most appropriate alternative for Celldex, and therefore our Board of Directors recommends that you vote for a one-year interval for the stockholder advisory votes on executive compensation.

        In formulating its recommendation, our Board considered that an annual advisory vote on executive compensation will allow our stockholders to provide us with their direct input on our compensation philosophy, policies and practices as disclosed in our proxy statements every year. The Board's determination was influenced by the fact that the compensation of our Named Executive Officers is evaluated, adjusted and approved on an annual basis. As part of the annual review process, the Board believes that stockholder sentiment should be a factor that is taken into consideration by the Board and the Compensation Committee in making decisions with respect to executive compensation.

        While the Board believes that its recommendation is appropriate at this time, stockholders are not voting to approve or disapprove that recommendation, but are instead asked to indicate their preference, on an advisory basis, as to whether the non-binding stockholder advisory votes on the approval of our Named Executive Officer compensation practices should be held every year, every two years or every three years. The option among those choices receiving the highest number of votes cast in person or by proxy at the Annual Meeting will be deemed to be the frequency preferred by our stockholders. The Board and the Compensation Committee value the opinions of our stockholders in this matter and, to the extent there is any significant vote in favor of one frequency over the other options, even if less than a majority of the votes cast support such frequency, the Board will consider our stockholders' concerns and evaluate any appropriate next steps. However, because this vote is advisory and not binding on the Board of Directors or Celldex in any way, the Board may decide that it is in the best interests of our stockholders and Celldex to hold stockholder advisory votes on executive compensation more or less frequently than the option approved by our stockholders.

THE BOARD RECOMMENDS A VOTE OF EVERY 1 YEAR ON THIS PROPOSAL NO. 7



STOCKHOLDER PROPOSALS

Stockholder Proposals for 20092018 Annual Meeting

        Any stockholder proposals submitted pursuant to Exchange Act Rule 14a-8 for inclusion in AVANT’sCelldex's proxy statement and form of proxy for our 2009 annual meeting2018 Annual Meeting must be received by AVANTCelldex on or before December 21, 200826, 2017 in order to be considered for inclusion in our proxy statement and form of proxy. Such proposal must also comply with the requirements as to form and substance established by the SEC if such proposals are to be included in the proxy statement and form of proxy. Any such proposal shall be mailed to: AVANT Immunotherapeutics.Celldex Therapeutics, Inc., 119 Fourth Avenue, Needham, MA 02494-2725,Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827, Attn.: Secretary.

Our by-laws state that the stockholder must provide timely written notice of such nomination or proposal and supporting documentation as well as be present at such meeting, either in person or by a representative. A stockholder’sstockholder's notice shall be timely received by AVANTCelldex at our principal executive office not less than seventy-five (75) days nor more than one hundred twenty (120) days prior to the anniversary date of the immediately preceding annual meeting (the “Anniversary Date”"Anniversary Date"); provided, however, that in the event the annual meeting is scheduled to be held on a date more than thirty (30) days before the Anniversary Date or more than sixty (60) days after the Anniversary Date, a stockholder’sstockholder's notice shall be timely if received by AVANTCelldex at our principal executive office not later than the close of business on the later of (1)(i) the seventy-fifth (75th) day prior to the scheduled date of such annual meeting or (2)(ii) the fifteenth (15th) day following the day on which such public announcement of the date of such annual meeting is first made by AVANT.Celldex. Proxies solicited by our Board of Directors will confer discretionary voting authority with respect to these proposals, subject to SEC rules and regulations governing the exercise of this authority. Any such proposal shall be mailed to: AVANT Immunotherapeutics.Celldex Therapeutics, Inc., 119 Fourth Avenue, Needham, Massachusetts 02494-2725,Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827, Attn.: Secretary.

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ANNUAL REPORTWHERE YOU CAN FIND ADDITIONAL INFORMAITON

        CopiesThe Company files annual, quarterly and current reports, proxy statements and other information with the SEC. Our SEC filings are available to the public over the Internet at the SEC's website athttp://www.sec.gov. The SEC's website contains reports, proxy statements and other information regarding issuers, such as Celldex Therapeutics, Inc., that file electronically with the SEC. You may also read and copy any document we file with the SEC at the SEC's Public Reference Room, located at 100 F Street, N.E., Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information on the operation of its Public Reference Room.

        The SEC allows the Company to "incorporate by reference" certain information the Company files with it, which means that the Company can disclose important information to you by referring you to those documents. The information incorporated by reference is considered to be part of this Proxy Statement, and information that the Company files later with the SEC will automatically update and supersede previously filed information, including information contained in this document. We are incorporating by reference the following, which include the information required by Item 13(a) of Schedule 14A and further information concerning the transactions described in Proposal 3:

    Sections of our Annual Report on Form 10-K (including audited financial statements), as amended,for the year ended December 31, 2016, filed with the SecuritiesSEC on March 14, 2017: "Part II. Item 7—Management's Discussion and Analysis of Financial Condition and Results of Operations," "Part II. Item 8—Financial Statements and Supplementary Data," "Part II. Item 7A—Quantitative and Qualitative Disclosure About Market Risk" and "Part II. Item 9—Changes in and Disagreements With Accountants on Accounting and Financial Disclosure;" and

    Our Current Reports on Form 8-K filed with the SEC on November 1, 2016 and November 29, 2016 (as amended by Amendment No. 1 on Form 8-K/A filed with the SEC on February 7, 2017) excluding any information deemed "furnished" and not "filed" pursuant to Item 2.02 or 7.01 of Form 8-K and exhibits filed on such form that are related to such item.

        In addition, all documents we file under Section 13(a), 13(c), 14 or 15(d) of the Exchange CommissionAct after the date of this Proxy Statement and before the date of the Annual Meeting are incorporated by reference into and deemed a part of this Proxy Statement from the date of filing of those documents.

        Any person, including any beneficial owner, to whom this Proxy Statement is delivered may be obtainedrequest copies of reports, proxy statements or other information concerning the Company (including the documents incorporated by reference herein) without charge, by writingwritten or telephonic request directed to our Corporate Secretary AVANT Immunotherapeutics,at Celldex Therapeutics, Inc., 119 Fourth Avenue, Needham, MA 02494.Perryville III Building, 53 Frontage Road, Suite 220, Hampton, NJ 08827. A request for a copycopies of our Annual Report on Form 10-Kreports, proxy statements or other information concerning the Company (including the documents incorporated by reference herein) must set forth a good-faith representation that the requesting party was either a holder of record or a beneficial owner of our common stock on August 15, 2008. Exhibits to the Form 10-K will be mailed upon similar request and payment of specified fees to cover the costs of copying and mailing such materials.April 20, 2017.


     Our audited financial statements for the fiscal year ended December 31, 2007 and certain other related financial and business information are contained in our 2007 Annual Report to Stockholders, which is being made available to our stockholders along with this proxy statement, but which is not deemed a part of the proxy soliciting material.

OTHER MATTERS

        As of the date of this proxy statement, the Board of Directors does not intend to present at the Annual Meeting any matters other than those described herein and does not presently know of any matters that will be presented by other parties. If any other matter requiring a vote of the stockholders should come before the meeting, it is the intention of the persons named in the proxy to vote with respect to any such matter in accordance with the recommendation of the Board of Directors or, in the absence of such a recommendation, in accordance with the best judgment of the proxy holder.

By Order of the Board of Directors

 
Avery C. Catlin
Chief Financial Officer and
/s/ AVERY W. CATLIN

Secretary

Hampton, NJ
May 3, 2017


Needham, MA
August __, 2008

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AVANT IMMUNOTHERAPEUTICS, INC.Appendix A

CELLDEX THERAPEUTICS, INC.
2008 STOCK OPTION AND INCENTIVE PLAN
as amended and restated effective as of June 10, 2015

This ProxySECTION 1.    GENERAL PURPOSE OF THE PLAN; DEFINITIONS

        The name of the plan is Solicitedthe Celldex Therapeutics, Inc. 2008 Stock Option and Incentive Plan (the "Plan"). The purpose of the Plan is to encourage and enable the officers, employees, Non-Employee Directors and other key persons (including consultants and prospective employees) of Celldex Therapeutics, Inc. (the "Company") and its Subsidiaries upon whose judgment, initiative and efforts the Company largely depends for the successful conduct of its business to acquire a proprietary interest in the Company. It is anticipated that providing such persons with a direct stake in the Company's welfare will assure a closer identification of their interests with those of the Company and its stockholders, thereby stimulating their efforts on Behalfthe Company's behalf and strengthening their desire to remain with the Company.

        The following terms shall be defined as set forth below:

        "Act" means the Securities Act of 1933, as amended, and the rules and regulations thereunder.

        "Administrator" means either the Board or the compensation committee of the Board of Directors
For The Annual Meeting of Shareholders on September 25, 2008

     The undersigned hereby appoints Anthony S. Marucci and Avery C. Catlin, and each of them as proxies, each with full power of substitution and authorizes them to represent and to vote as designated onor a similar committee performing the reverse side of this form, all the shares of Common Stock of AVANT Immunotherapeutics, Inc. held of record by the undersigned on August 15, 2008, at the Annual Meeting Shareholders to be held on September 25, 2008, at 9:00 a.m. local time at 1251 Avenuefunctions of the Americas, 18th Floor, New York, NY 10020, or any adjournment or postponementcompensation committee and which is comprised of such meeting.

THIS PROXY WHEN PROPERLY EXECUTED, WILL BE VOTED IN THE MANNER DIRECTED HEREIN BY THE UNDERSIGNED SHAREHOLDER. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR THE PROPOSALS LISTED HEREIN.not less than two Non-Employee Directors who are independent.

(Continued and to be signed on the reverse side)


ANNUAL MEETING OF SHAREHOLDERS OF

AVANT IMMUNOTHERAPEUTICS, INC.

September 25, 2008

Please date, sign and mail your
proxy card in the envelope provided as soon as possible!

Please detach along perforated line        "Award" or"Awards," except where referring to a particular category of grant under the Plan, shall include Incentive Stock Options, Non-Qualified Stock Options, Stock Appreciation Rights, Deferred Stock Awards, Restricted Stock Awards, Unrestricted Stock Awards, Cash-Based Awards, Performance Share Awards and mail inDividend Equivalent Rights.

        "Award Agreement" means a written or electronic agreement setting forth the envelope provided

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS
A VOTE FOR ALL OF THE PROPOSALS.
Please Mark Your Vote In Blue Or Black As Shown Here x

1.

ELECTION OF DIRECTORS

For All

Withhold
All

For All
Except

ooo

Nominees:  

01) Charles R. Schaller,
02) Herbert J. Conrad,
03) Larry Ellberger,
04) George O. Elston,
05) Karen Shoos Lipton,
06) Dr. Rajesh B. Parekh, and
07) Harry H. Penner, Jr.

2.

TORATIFY THE APPOINTMENT OF PRICEWATERHOUSECOOPERS LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 2008;

oFOR  oAGAINST

3.

APPROVE AN AMENDMENT TO OUR CERTIFICATE OF INCORPORATION TO CHANGE OUR NAME TO CELLDEX THERAPEUTICS, INC.; AND

oFOR  oAGAINST

4.

IN THEIR DISCRETION, UPON SUCH OTHER BUSINESS AS MAY PROPERLY COME BEFORE THE ANNUALMEETING OR ANY ADJOURNMENT OR POSTPONEMENT

PLEASE MARK, SIGN AND DATE THIS PROXY CARD AND PROMPTLY RETURN IT IN THE ENVELOPEPROVIDED. NO POSTAGE NECESSARY IF MAILED WITHIN THE UNITED STATES.



  Dated:
, 2008
(SIGNATURE)(SIGNATURE, IF HELD JOINTLY)

NOTE:

Please sign exactly as your name appears hereon and mail it promptly even though you may plan to attend the meeting. When shares are held by joint tenants, both should sign. When signing as attorney, executor, administrator, trustee or guardian, please give full title as such. If a corporation, please sign in full corporate name by president or other authorized officer. If a partnership, please sign in the partnership name by authorized person.



Annexure A

CERTIFICATE OF AMENDMENT OF
CERTIFICATE OF INCORPORATION

OF AVANT IMMUNOTHERAPEUTICS, INC.

The corporation organizedterms and existingprovisions applicable to an Award granted under the Plan. Each Award Agreement is subject to the terms and by virtueconditions of the General Corporation Law of the State of Delaware does hereby certify:Plan.

FIRST        ": That at a meeting ofBoard" means the Board of Directors of AVANT Immunotherapeutics, Inc.resolutions were duly adopted setting forththe Company.

        "Cash-Based Award" means an Award entitling the recipient to receive a proposed amendmentcash-denominated payment.

        "Change of Control" is defined in Section 20.

        "Code" means the Internal Revenue Code of 1986, as amended, and any successor Code, and related rules, regulations and interpretations.

        "Covered Employee" means an employee who is a "Covered Employee" within the meaning of Section 162(m) of the CertificateCode.

        "Date of Incorporation of said corporation, declaring said amendmentGrant" means the date on which an Award under the Plan is granted by the Administrator, or such later date as the Administrator may specify to be advisablethe effective date of an Award.

        "Deferred Stock Award" means an Award of phantom stock units to a grantee.

        "Disability" means a grantee being considered "disabled" within the meaning of Section 409A and callingTreasury Regulation 1.409A-3(i)(4), as well as any successor regulation or interpretation.

        "Dividend Equivalent Right" means an Award entitling the grantee to receive credits based on cash dividends that would have been paid on the shares of Stock specified in the Dividend Equivalent Right (or other award to which it relates) if such shares had been issued to and held by the grantee.


        "Effective Date" means the date on which the amended and restated Plan is approved by stockholders as set forth in Section 22.

        "Exchange Act" means the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder.

        "Fair Market Value" of a meetingshare of Stock shall be, as applied to a specific date (i) the closing price of a share of Stock as of the stockholdersdate of said corporation for consideration thereof. The resolution setting forthdetermination on the proposed amendmentprincipal established stock exchange or national market system on which the Stock is then traded (or, if there is no trading in the Stock as follows:

RESOLVED, thatof such date, the Certificateclosing price of Incorporationa share of this corporation be amended by changing Article OneStock on the most recent date preceding the date of determination on which trades of the CertificateStock were recorded), or (ii) if the shares of Incorporation so that, as amended, said Article shall be and read as follows:

"1.The nameStock are not then traded on an established stock exchange or national market system but are then traded in an over-the-counter market, the average of the Corporationclosing bid and asked prices for the shares of Stock in such over-the-counter market as of the date of determination (or, if there are no closing bid and asked prices for the shares of Stock as of such date, the average of the closing bid and the asked prices for the shares of Stock on the most recent date preceding such date on which such closing bid and asked prices are available on such over-the-counter market), or (iii) if the shares of Stock are not then listed on a national securities exchange or national market system or traded in an over-the-counter market, the price of a share of Stock as determined by the Administrator in its discretion in a manner consistent with Section 409A of the Code and Treasury Regulation 1.409A-1(b)(5)(iv), as well as any successor regulation or interpretation.

        "Incentive Stock Option" means any Stock Option designated and qualified as an "incentive stock option" as defined in Section 422 of the Code.

        "Non-Employee Director" means a member of the Board who is Celldex Therapeutics, Inc."not also an employee of the Company or any Subsidiary.

SECOND        ": That thereafter,Non-Qualified Stock Option" means any Stock Option that is not an Incentive Stock Option.

        "Option" or"Stock Option" means any option to purchase shares of Stock granted pursuant to resolution of its Board of Directors, said amendment was submitted for stockholder approval at an annual meetingSection 5.

        "Performance-Based Award" means any Restricted Stock Award, Deferred Stock Award, Performance Share Award or Cash-Based Award granted to a Covered Employee that is intended to qualify as "performance-based compensation" under Section 162(m) of the stockholders of said corporationCode and held upon noticethe regulations promulgated thereunder.

        "Performance Criteria" means the performance criteria used in accordance with Section 222performance goals governing Performance-based Awards granted to Covered Employees which may include any or all of the General Corporation Lawfollowing: (i) the Company's return on equity, assets, capital or investment, (ii) pre-tax or after-tax profit levels of the StateCompany or any Subsidiary, a division, an operating unit or a business segment of Delawarethe Company, or any combination of the foregoing; (iii) cash flow, funds from operations, year-end cash and equivalents balance or similar measure; (iv) total shareholder return; (v) changes in the market price of the Stock; (vi) sales or market share; (vii) earnings per share; (viii) partnerships, collaborations, joint ventures, alliances and similar arrangements involving the Company; (ix) mergers, acquisitions and business combinations of or by the Company; or (x) the Company's rights to intellectual property and scientific discoveries.

        "Performance Cycle" means one or more periods of time, which may be of varying and overlapping durations, as the Administrator may select, over which the attainment of one or more Performance Criteria will be measured for the purpose of determining a grantee's right to and the payment of a Restricted Stock Award, Deferred Stock Award, Performance Share Award or Cash-Based Award.

        "Performance Goals" means, for a Performance Cycle, the specific goals established in writing by the Administrator for a Performance Cycle based upon the Performance Criteria.


        "Performance Share Award" means an Award entitling the recipient to acquire shares of Stock upon the attainment of specified Performance Goals.

        "Restricted Stock Award" means an Award entitling the recipient to acquire, at such purchase price (which may be zero) as determined by the Administrator, shares of Stock subject to such restrictions and conditions as the Administrator may determine at the time of grant.

        "Sale Event" shall mean (i) the sale of all or substantially all of the assets of the Company on a consolidated basis to an unrelated person or entity, (ii) a merger, reorganization or consolidation in which meeting the necessaryoutstanding shares of Stock are converted into or exchanged for securities of the successor entity and the holders of the Company's outstanding voting power immediately prior to such transaction do not own a majority of the outstanding voting power of the successor entity immediately upon completion of such transaction, or (iii) the sale of all of the Stock of the Company to an unrelated person or entity.

        "Sale Price" means the value as determined by the Administrator of the consideration payable, or otherwise to be received by stockholders, per share of Stock pursuant to a Sale Event.

        "Section 409A" means Section 409A of the Code and the regulations and other guidance promulgated thereunder.

        "Stock" means the Common Stock, par value $.01 per share, of the Company, subject to adjustments pursuant to Section 3.

        "Stock Appreciation Right" means an Award entitling the recipient to receive shares of Stock having a value equal to the excess of the Fair Market Value of the Stock on the date of exercise over the exercise price of the Stock Appreciation Right multiplied by the number of shares asof Stock with respect to which the Stock Appreciation Right shall have been exercised.

        "Subsidiary" means any corporation or other entity (other than the Company) in which the Company has at least a 50 percent interest, either directly or indirectly.

        "Ten Percent Owner" means an employee who owns or is deemed to own (by reason of the attribution rules of Section 424(d) of the Code) more than 10 percent of the combined voting power of all classes of stock of the Company or any parent or subsidiary corporation.

        "Unrestricted Stock Award" means an Award of shares of Stock free of any restrictions.

SECTION 2.    ADMINISTRATION OF PLAN; ADMINISTRATOR AUTHORITY TO SELECT GRANTEES AND DETERMINE AWARDS

        (a)    Administration of Plan.    The Plan shall be administered by the Administrator. To the extent advisable or otherwise required by statute were voted in favorapplicable law, regulation or rule, it is intended that each member of the amendment.Administrator shall qualify as (i) a "non-employee director" under Rule 16b-3, (ii) an "outside director" under Section 162(m) of the Code and the regulations thereunder and (iii) an "independent director" under the rules of any national securities exchange on which the shares of Stock are then listed. If it is later determined that one or more members of the Administrator do not so qualify, actions taken by the Administrator shall be valid despite such failure to qualify.

THIRD        (b): That said amendment was duly adopted    Powers of Administrator.    The Administrator shall have the power and authority to grant Awards consistent with the terms of the Plan, including the power and authority:

              (i)  to select the individuals to whom Awards may from time to time be granted;

             (ii)  to determine the time or times of grant, and the extent, if any, of Incentive Stock Options, Non-Qualified Stock Options, Stock Appreciation Rights, Restricted Stock Awards, Deferred Stock Awards, Unrestricted Stock Awards, Cash-Based Awards, Performance Share


    Awards and Dividend Equivalent Rights, or any combination of the foregoing, granted to any one or more grantees;

            (iii)  to determine the number of shares of Stock to be covered by any Award;

            (iv)  to determine and modify from time to time the terms and conditions, including restrictions, not inconsistent with the terms of the Plan, of any Award, which terms and conditions may differ among individual Awards and grantees, and to approve the form of written instruments evidencing the Awards;

             (v)  to accelerate the exercisability or vesting of all or any portion of any Award upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event;

            (vi)  subject to the provisions of Section 5(b), to extend at any time the period in which Stock Options may be exercised; and

           (vii)  at any time to adopt, alter and repeal such rules, guidelines and practices for administration of the Plan and for its own acts and proceedings as it shall deem advisable; to interpret the terms and provisions of the Plan and any Award (including related written instruments); to make all determinations it deems advisable for the administration of the Plan; to decide all disputes arising in connection with the Plan; and to otherwise supervise the administration of the Plan.

        All decisions and interpretations of the Administrator shall be binding on all persons, including the Company and Plan grantees.

        (c)    Delegation of Authority to Grant Options.    Subject to applicable law, the Administrator, in its discretion, may delegate to the Chief Executive Officer of the Company all or part of the Administrator's authority and duties with respect to the granting of Options, to individuals who are (i) not subject to the reporting and other provisions of Section 16 of the Exchange Act and (ii) not Covered Employees. Any such delegation by the Administrator shall include a limitation as to the amount of Options that may be granted during the period of the delegation and shall contain guidelines as to the determination of the exercise price and the vesting criteria. The Administrator may revoke or amend the terms of a delegation at any time but such action shall not invalidate any prior actions of the Administrator's delegate or delegates that were consistent with the terms of the Plan.

        (d)    Award Agreement.    Awards under the Plan shall be evidenced by Award Agreements that set forth the terms, conditions and limitations for each Award which may include, without limitation, the term of an Award, the provisions applicable in the event employment or service terminates, and the Company's authority to unilaterally or bilaterally amend, modify, suspend, cancel or rescind an Award.

        (e)    Indemnification.    Neither the Board nor the Administrator, nor any member of either or any delegate thereof, shall be liable for any act, omission, interpretation, construction or determination made in good faith in connection with the Plan, and the members of the Board and the Administrator (and any delegate thereof) shall be entitled in all cases to indemnification and reimbursement by the Company in respect of any claim, loss, damage or expense (including, without limitation, reasonable attorneys' fees) arising or resulting therefrom to the fullest extent permitted by law and/or under the Company's articles or bylaws or any directors' and officers' liability insurance coverage which may be in effect from time to time and/or any indemnification agreement between such individual and the Company.

SECTION 3.    STOCK ISSUABLE UNDER THE PLAN; MERGERS; SUBSTITUTION

        (a)    Stock Issuable.    The maximum number of shares of Stock reserved and available for issuance under the Plan shall be 14,350,000 shares, subject to adjustment as provided in Section 3(b) (the "Share Reserve"); provided that not more than 500,000 shares shall be issued in the form of Unrestricted Stock


Awards, Restricted Stock Awards, Deferred Stock Awards or Performance Share Awards. For purposes of this limitation, the shares of Stock underlying the Awards granted under the Plan that are forfeited, canceled or otherwise terminated (other than by exercise) shall be added back to the shares of Stock available for issuance under the Plan. Shares (i) tendered or withheld in payment of an Option, (ii) tendered or withheld to satisfy any tax withholding obligation or (iii) repurchased by the Company with Option proceeds, shall not revert to or be added back to the Share Reserve. Further, shares of Stock covered by a Stock Appreciation Right, to the extent that it is exercised and settled in shares of Stock, and whether or not shares of Stock are actually issued to the grantee upon the exercise of the Stock Appreciation Right, shall be considered issued or transferred pursuant to the Plan. Subject to such overall limitations, shares of Stock may be issued up to such maximum number pursuant to any type or types of Award; provided, however, that Stock Options or Stock Appreciation Rights with respect to no more than 2,000,000 shares of Stock may be granted to any one individual grantee during any one calendar year period. The shares available for issuance under the Plan may be authorized but unissued shares of Stock or shares of Stock reacquired by the Company.

        (b)    Changes in Stock.    Subject to Section 3(c) hereof, if, as a result of any reorganization, recapitalization, reclassification, stock dividend, stock split, reverse stock split or other similar change in the Company's capital stock, the outstanding shares of Stock are increased or decreased or are exchanged for a different number or kind of shares or other securities of the Company, or additional shares or new or different shares or other securities of the Company or other non-cash assets are distributed with respect to such shares of Stock or other securities, or, if, as a result of any merger or consolidation, sale of all or substantially all of the assets of the Company, the outstanding shares of Stock are converted into or exchanged for securities of the Company or any successor entity (or a parent or subsidiary thereof), the Administrator shall make an appropriate or proportionate adjustment in (i) the maximum number of shares reserved for issuance under the Plan, including the maximum number of shares that may be issued in the form of Unrestricted Stock Awards, Restricted Stock Awards, Deferred Stock Awards or Performance Share Awards, (ii) the number of Stock Options or Stock Appreciation Rights that can be granted to any one individual grantee in one calendar year and the maximum number of shares that may be granted under a Performance-Based Award, (iii) the number and kind of shares or other securities subject to any then outstanding Awards under the Plan, (iv) the repurchase price, if any, per share subject to each outstanding Restricted Stock Award, and (v) the price for each share subject to any then outstanding Stock Options and Stock Appreciation Rights under the Plan, without changing the aggregate exercise price (i.e., the exercise price multiplied by the number of Stock Options and Stock Appreciation Rights) as to which such Stock Options and Stock Appreciation Rights remain exercisable. The Administrator shall also make equitable or proportionate adjustments in the number of shares subject to outstanding Awards and the exercise price and the terms of outstanding Awards to take into consideration cash dividends paid other than in the ordinary course or any other extraordinary corporate event. The adjustment by the Administrator shall be final, binding and conclusive. No fractional shares of Stock shall be issued under the Plan resulting from any such adjustment, but the Administrator in its discretion may make a cash payment in lieu of fractional shares.

        (c)    Mergers and Other Transactions.    Upon the effective time of the Sale Event, the Plan and all outstanding Awards granted hereunder shall terminate, unless provision is made in connection with the Sale Event in the sole discretion of the parties thereto for the assumption or continuation by the successor entity of Awards theretofore granted, or the substitution of such Awards with new Awards of the successor entity or parent thereof, with appropriate adjustment as to the number and kind of shares and, if appropriate, the per share exercise prices, as such parties shall agree (after taking into account any acceleration hereunder). In the event of such termination, (i) the Company shall have the option (in its sole discretion) to make or provide for a cash payment to the grantees holding Options and Stock Appreciation Rights, in exchange for the cancellation thereof, in an amount equal to the difference between (A) the Sale Price multiplied by the number of shares of Stock subject to


outstanding Options and Stock Appreciation Rights (to the extent then exercisable (after taking into account any acceleration hereunder) at prices not in excess of the Sale Price) and (B) the aggregate exercise price of all such outstanding Options and Stock Appreciation Rights; or (ii) each grantee shall be permitted, within a specified period of time prior to the consummation of the Sale Event as determined by the Administrator, to exercise all outstanding Options and Stock Appreciation Rights held by such grantee.

        (d)    Substitute Awards.    The Administrator may grant Awards under the Plan in substitution for stock and stock based awards held by employees, directors or other key persons of another corporation in connection with the merger or consolidation of the employing corporation with the Company or a Subsidiary or the acquisition by the Company or a Subsidiary of property or stock of the employing corporation. The Administrator may direct that the substitute awards be granted on such terms and conditions as the Administrator considers appropriate in the circumstances. Any substitute Awards granted under the Plan shall not count against the share limitation set forth in Section 3(a).

SECTION 4.    ELIGIBILITY

        Grantees under the Plan will be such full or part-time officers and other employees, Non-Employee Directors and key persons (including consultants and prospective employees) of the Company and its Subsidiaries as are selected from time to time by the Administrator in its sole discretion.

SECTION 5.    STOCK OPTIONS

        Any Stock Option granted under the Plan shall be in such form as the Administrator may from time to time approve.

        Stock Options granted under the Plan may be either Incentive Stock Options or Non-Qualified Stock Options. Incentive Stock Options may be granted only to employees of the Company or any Subsidiary that is a "subsidiary corporation" within the meaning of Section 424(f) of the Code. To the extent that any Option does not qualify as an Incentive Stock Option, it shall be deemed a Non-Qualified Stock Option.

        Stock Options granted pursuant to this Section 5 shall be subject to the following terms and conditions and shall contain such additional terms and conditions, not inconsistent with the terms of the Plan, as the Administrator shall deem desirable.

        (a)    Exercise Price.    The exercise price per share for the Stock covered by a Stock Option granted pursuant to this Section 5 shall be determined by the Administrator at the time of grant but shall not be less than 100 percent of the Fair Market Value on the Date of Grant. In the case of an Incentive Stock Option that is granted to a Ten Percent Owner, the option price of such Incentive Stock Option shall be not less than 110 percent of the Fair Market Value on the Date of Grant.

        (b)    Option Term.    The term of each Stock Option shall be fixed by the Administrator, but no Stock Option shall be exercisable more than ten years after the date the Stock Option is granted. In the case of an Incentive Stock Option that is granted to a Ten Percent Owner, the term of such Stock Option shall be no more than five years from the Date of Grant.

        (c)    Exercisability; Rights of a Stockholder.    Stock Options shall become exercisable at such time or times, whether or not in installments, as shall be determined by the Administrator at or after the grant date. The Administrator may accelerate the exercisability of all or any portion of any Stock Option upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event. An optionee shall have the rights of a stockholder only as to shares acquired upon the exercise of a Stock Option and not as to unexercised Stock Options.


        (d)    Method of Exercise.    Stock Options may be exercised in whole or in part, by giving written notice of exercise to the Company, specifying the number of shares to be purchased. Payment of the purchase price may be made by one or more of the following methods to the extent provided in the Option Award Agreement:

              (i)  In cash, by certified or bank check or other instrument acceptable to the Administrator;

             (ii)  Through the delivery (or attestation to the ownership) of shares of Stock that have been purchased by the optionee on the open market or that are beneficially owned by the optionee and are not then subject to restrictions under any Company plan. Such surrendered shares shall be valued at Fair Market Value on the exercise date. To the extent required to avoid variable accounting treatment under applicable accounting rules, such surrendered shares shall have been owned by the optionee for at least six months; or

            (iii)  By the optionee delivering to the Company a properly executed exercise notice together with irrevocable instructions to a broker to promptly deliver to the Company cash or a check payable and acceptable to the Company for the purchase price; provided that in the event the optionee chooses to pay the purchase price as so provided, the optionee and the broker shall comply with such procedures and enter into such agreements of indemnity and other agreements as the Administrator shall prescribe as a condition of such payment procedure.

    Payment instruments will be received subject to collection. The transfer to the optionee on the records of the Company or of the transfer agent of the shares of Stock to be purchased pursuant to the exercise of a Stock Option will be contingent upon receipt from the optionee (or a purchaser acting in his stead in accordance with the provisions of Section 242the Stock Option) by the Company of the General Corporation Lawfull purchase price for such shares and the fulfillment of any other requirements contained in the Option Award Agreement or applicable provisions of laws (including the satisfaction of any withholding taxes that the Company is obligated to withhold with respect to the optionee). In the event an optionee chooses to pay the purchase price by previously-owned shares of Stock through the attestation method, the number of shares of Stock transferred to the optionee upon the exercise of the Stock Option shall be net of the number of attested shares. In the event that the Company establishes, for itself or using the services of a third party, an automated system for the exercise of Stock Options, such as a system using an internet website or interactive voice response, then the paperless exercise of Stock Options may be permitted through the use of such an automated system.

            (iv)    Annual Limit on Incentive Stock Options.    To the extent required for "incentive stock option" treatment under Section 422 of the Code, the aggregate Fair Market Value (determined as of the time of grant) of the shares of Stock with respect to which Incentive Stock Options granted under this Plan and any other plan of the Company or its parent and subsidiary corporations become exercisable for the first time by an optionee during any calendar year shall not exceed $100,000. To the extent that any Stock Option exceeds this limit, it shall constitute a Non-Qualified Stock Option.

SECTION 6.    STOCK APPRECIATION RIGHTS

        (a)    Exercise Price of Stock Appreciation Rights.    The exercise price of a Stock Appreciation Right shall not be less than 100 percent of the Fair Market Value of the Stock on the Date of Grant.

        (b)    Grant and Exercise of Stock Appreciation Rights.    Stock Appreciation Rights may be granted by the Administrator independently of any Stock Option granted pursuant to Section 5 of the Plan.

        (c)    Terms and Conditions of Stock Appreciation Rights.    Stock Appreciation Rights shall be subject to such terms and conditions as shall be determined from time to time by the Administrator.


SECTION 7.    RESTRICTED STOCK AWARDS

        (a)    Nature of Restricted Stock Awards.    The Administrator shall determine the restrictions and conditions applicable to each Restricted Stock Award at the time of grant. Conditions may be based on continuing employment (or other service relationship) and/or achievement of pre-established performance goals and objectives. The grant of a Restricted Stock Award is contingent on the grantee executing the Restricted Stock Award Agreement. The terms and conditions of each such Award Agreement shall be determined by the Administrator, and such terms and conditions may differ among individual Awards and grantees.

        (b)    Rights as a Stockholder.    Upon execution of the Restricted Stock Award Agreement and payment of any applicable purchase price, a grantee shall have the rights of a stockholder with respect to the voting of the Restricted Stock, subject to such conditions contained in the Restricted Stock Award Agreement. Unless the Administrator shall otherwise determine, (i) uncertificated Restricted Stock shall be accompanied by a notation on the records of the Company or the transfer agent to the effect that they are subject to forfeiture until such Restricted Stock are vested as provided in Section 7(d) below, and (ii) certificated Restricted Stock shall remain in the possession of the Company until such Restricted Stock is vested as provided in Section 7(d) below, and the grantee shall be required, as a condition of the grant, to deliver to the Company such instruments of transfer as the Administrator may prescribe.

        (c)    Restrictions.    Restricted Stock may not be sold, assigned, transferred, pledged or otherwise encumbered or disposed of except as specifically provided herein or in the Restricted Stock Award Agreement. Except as may otherwise be provided by the Administrator either in the Award Agreement or, subject to Section 18 below, in writing after the Award Agreement is issued if a grantee's employment (or other service relationship) with the Company and its Subsidiaries terminates for any reason, any Restricted Stock that has not vested at the time of termination shall automatically and without any requirement of notice to such grantee from or other action by or on behalf of, the Company be deemed to have been reacquired by the Company at its original purchase price (if any) from such grantee or such grantee's legal representative simultaneously with such termination of employment (or other service relationship), and thereafter shall cease to represent any ownership of the Company by the grantee or rights of the grantee as a stockholder. Following such deemed reacquisition of unvested Restricted Stock that are represented by physical certificates, a grantee shall surrender such certificates to the Company upon request without consideration.

        (d)    Vesting of Restricted Stock.    The Administrator at the time of grant shall specify the date or dates and/or the attainment of pre-established performance goals, objectives and other conditions on which the non-transferability of the Restricted Stock and the Company's right of repurchase or forfeiture shall lapse. Notwithstanding the foregoing, in the event that any such Restricted Stock granted to employees shall have a performance-based goal, the restriction period with respect to such shares shall not be less than one year, and in the event any such Restricted Stock granted to employees shall have a time-based restriction, the total restriction period with respect to such shares shall not be less than three years; provided, however, that Restricted Stock with a time-based restriction may become vested incrementally over such three-year period. Subsequent to such date or dates and/or the attainment of such pre-established performance goals, objectives and other conditions, the shares on which all restrictions have lapsed shall no longer be Restricted Stock and shall be deemed "vested." Except as may otherwise be provided by the Administrator either in the Award Agreement or, subject to Section 18 below, in writing after the Award Agreement is issued (but in such case only with respect to acceleration of vesting upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event), a grantee's rights in any shares of Restricted Stock that have not vested shall automatically terminate upon the grantee's termination of employment (or other service relationship) with the Company and its Subsidiaries and such shares shall be subject to the provisions of Section 7(c) above.


SECTION 8.    DEFERRED STOCK AWARDS

        (a)    Nature of Deferred Stock Awards.    The Administrator shall determine the restrictions and conditions applicable to each Deferred Stock Award at the time of grant. Conditions may be based on continuing employment (or other service relationship) and/or achievement of pre-established performance goals and objectives. The grant of a Deferred Stock Award is contingent on the grantee executing the Deferred Stock Award Agreement. The terms and conditions of each such Award Agreement shall be determined by the Administrator, and such terms and conditions may differ among individual Awards and grantees. Notwithstanding the foregoing, in the event that any such Deferred Stock Award granted to employees shall have a performance-based goal, the restriction period with respect to such Award shall not be less than one year, and in the event any such Deferred Stock Award granted to employees shall have a time-based restriction, the total restriction period with respect to such Award shall not be less than three years; provided, however, that any Deferred Stock Award with a time-based restriction may become vested incrementally over such three-year period. At the end of the deferral period, the Deferred Stock Award, to the extent vested, shall be settled in the form of shares of Stock. To the extent that a Deferred Stock Award is subject to Section 409A, it may contain such additional terms and conditions as the Administrator shall determine in its sole discretion in order for such Award to comply with the requirements of Section 409A.

        (b)    Election to Receive Deferred Stock Awards in Lieu of Compensation.    The Administrator may, in its sole discretion, permit a grantee to elect to receive a portion of future cash compensation otherwise due to such grantee in the form of a Deferred Stock Award. Any such election shall be made in writing and shall be delivered to the Company no later than the date specified by the Administrator and in accordance with Section 409A and such other rules and procedures established by the Administrator. Any such future cash compensation that the grantee elects to defer shall be converted to a fixed number of phantom stock units based on the Fair Market Value of Stock on the date the compensation would otherwise have been paid to the grantee if such payment had not been deferred as provided herein. The Administrator shall have the sole right to determine whether and under what circumstances to permit such elections and to impose such limitations and other terms and conditions thereon as the Administrator deems appropriate.

        (c)    Rights as a Stockholder.    A grantee shall have the rights as a stockholder only as to shares of Stock acquired by the grantee upon settlement of a Deferred Stock Award; provided, however, that the grantee may be credited with Dividend Equivalent Rights with respect to the phantom stock units underlying his Deferred Stock Award, subject to such terms and conditions as the Administrator may determine.

        (d)    Termination.    Except as may otherwise be provided by the Administrator either in the Award Agreement or, subject to Section 18 below, in writing after the Award Agreement is issued (but in such case only with respect to acceleration of vesting upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event), a grantee's right in all Deferred Stock Awards that have not vested shall automatically terminate upon the grantee's termination of employment (or cessation of service relationship) with the Company and its Subsidiaries for any reason.

SECTION 9.    UNRESTRICTED STOCK AWARDS

        Grant or Sale of Unrestricted Stock.    The Administrator may, in its sole discretion, grant (or sell at par value or such higher purchase price determined by the Administrator) an Unrestricted Stock Award under the Plan. Unrestricted Stock Awards may be granted in respect of past services or other valid consideration, or in lieu of cash compensation due to such grantee.

SECTION 10.    CASH-BASED AWARDS

        Grant of Cash-Based Awards.    The Administrator may, in its sole discretion, grant Cash-Based Awards to any grantee in such number or amount and upon such terms, and subject to such conditions,


as the Administrator shall determine at the time of grant. The Administrator shall determine the maximum duration of the Cash-Based Award, the amount of cash to which the Cash-Based Award pertains, the conditions upon which the Cash-Based Award shall become vested or payable, and such other provisions as the Administrator shall determine. Each Cash-Based Award shall specify a cash-denominated payment amount, formula or payment ranges as determined by the Administrator. Payment, if any, with respect to a Cash-Based Award shall be made in accordance with the terms of the Award and may be made in cash or in shares of Stock, as the Administrator determines.

SECTION 11.    PERFORMANCE SHARE AWARDS

        (a)    Nature of Performance Share Awards.    The Administrator may, in its sole discretion, grant Performance Share Awards independent of, or in connection with, the granting of any other Award under the Plan. The Administrator shall determine whether and to whom Performance Share Awards shall be granted, the Performance Goals, the periods during which performance is to be measured, and such other limitations and conditions as the Administrator shall determine.

        (b)    Rights as a Stockholder.    A grantee receiving a Performance Share Award shall have the rights of a stockholder only as to shares actually received by the grantee under the Plan and not with respect to shares subject to the Award but not actually received by the grantee. A grantee shall be entitled to receive shares of Stock under a Performance Share Award only upon satisfaction of all conditions specified in the Performance Share Award agreement (or in a performance plan adopted by the Administrator).

        (c)    Termination.    Except as may otherwise be provided by the Administrator either in the Award agreement or, subject to Section 18 below, in writing after the Award agreement is issued (but in such case only with respect to acceleration of vesting upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event), a grantee's rights in all Performance Share Awards shall automatically terminate upon the grantee's termination of employment (or cessation of service relationship) with the Company and its Subsidiaries for any reason.

SECTION 12.    PERFORMANCE-BASED AWARDS TO COVERED EMPLOYEES

        (a)    Performance-Based Awards.    Any employee or other key person providing services to the Company and who is selected by the Administrator may be granted one or more Performance-Based Awards in the form of a Restricted Stock Award, Deferred Stock Award, Performance Share Awards or Cash-Based Award payable upon the attainment of Performance Goals that are established by the Administrator and relate to one or more of the Performance Criteria, in each case on a specified date or dates or over any period or periods determined by the Administrator. The Administrator shall define in an objective fashion the manner of calculating the Performance Criteria it selects to use for any Performance Period. Depending on the Performance Criteria used to establish such Performance Goals, the Performance Goals may be expressed in terms of overall Company performance or the performance of a division, business unit, or an individual. The Administrator, in its discretion, may adjust or modify the calculation of Performance Goals for such Performance Period in order to prevent the dilution or enlargement of the rights of an individual (i) in the event of, or in anticipation of, any unusual or extraordinary corporate item, transaction, event or development, (ii) in recognition of, or in anticipation of, any other unusual or nonrecurring events affecting the Company, or the financial statements of the Company, or (iii) in response to, or in anticipation of, changes in applicable laws, regulations, accounting principles, or business conditions provided however, that the Administrator may not exercise such discretion in a manner that would increase the Performance-Based Award granted to a Covered Employee. Each Performance-Based Award shall comply with the provisions set forth below.

        (b)    Grant of Performance-Based Awards.    With respect to each Performance-Based Award granted to a Covered Employee, the Administrator shall select, within the first 90 days of a Performance Cycle (or, if shorter, within the maximum period allowed under Section 162(m) of the


Code) the Performance Criteria for such grant, and the Performance Goals with respect to each Performance Criterion (including a threshold level of performance below which no amount will become payable with respect to such Award). Each Performance-Based Award will specify the amount payable, or the formula for determining the amount payable, upon achievement of the various applicable performance targets. The Performance Criteria established by the Administrator may be (but need not be) different for each Performance Cycle and different Performance Goals may be applicable to Performance-Based Awards to different Covered Employees.

        (c)    Payment of Performance-Based Awards.    Following the completion of a Performance Cycle, the Administrator shall meet to review and certify in writing whether, and to what extent, the Performance Goals for the Performance Cycle have been achieved and, if so, to also calculate and certify in writing the amount of the Performance-Based Awards earned for the Performance Cycle. The Administrator shall then determine the actual size of each Covered Employee's Performance-Based Award, and, in doing so, may reduce or eliminate the amount of the Performance-Based Award for a Covered Employee if, in its sole judgment, such reduction or elimination is appropriate.

        (d)    Maximum Award Payable.    The maximum Performance-Based Award payable to any one Covered Employee under the Plan in respect of any calendar year is (i) 250,000 shares of Stock (subject to adjustment as provided in Section 3(b) hereof) for a Performance-Based Award that is a Restricted Stock Award, Deferred Stock Award or Performance Share Award and (ii) $1,000,000 in value for a Performance-Based Award that is a Cash-Based Award. In the case of Performance Goals based on Performance Cycles beginning and ending in different calendar years, the number of shares of Stock or cash amount which is paid in respect of each calendar year during the Performance Cycle shall be determined by multiplying the total number of shares of Stock or cash amount, as applicable, paid for the Performance Cycle by a fraction, of which (i) the numerator is the number of days during the Performance Cycle in that particular calendar year, and (ii) the denominator is the total number of days during the Performance Cycle. The limitations in this Section 12(d) shall be interpreted and applied in a manner consistent with Section 162(m) of the Code and the regulations thereunder.

SECTION 13.    DIVIDEND EQUIVALENT RIGHTS

        (a)    Dividend Equivalent Rights.    A Dividend Equivalent Right may be granted hereunder to any grantee as a component of a Deferred Stock Award, Restricted Stock Award or Performance Share Award or as a freestanding award. The terms and conditions of Dividend Equivalent Rights shall be specified in the Award Agreement. Dividend equivalents credited to the holder of a Dividend Equivalent Right may be paid currently or may be deemed to be reinvested in additional shares of Stock, which may thereafter accrue additional equivalents. Any such reinvestment shall be at Fair Market Value on the date of reinvestment or such other price as may then apply under a dividend reinvestment plan sponsored by the Company, if any. Dividend Equivalent Rights may be settled in cash or shares of Stock or a combination thereof, in a single installment or installments. A Dividend Equivalent Right granted as a component of a Deferred Stock Award, Restricted Stock Award or Performance Share Award may provide that such Dividend Equivalent Right shall be settled upon settlement or payment of, or lapse of restrictions on, such other Award, and that such Dividend Equivalent Right shall expire or be forfeited or annulled under the same conditions as such other Award. A Dividend Equivalent Right granted as a component of a Deferred Stock Award, Restricted Stock Award or Performance Share Award may also contain terms and conditions different from such other Award.

        (b)    Interest Equivalents.    Any Award under this Plan that is settled in whole or in part in cash on a deferred basis may provide in the grant for interest equivalents to be credited with respect to such cash payment. Interest equivalents may be compounded and shall be paid upon such terms and conditions as may be specified by the grant.


        (c)    Termination.    Except as may otherwise be provided by the Administrator either in the Award Agreement or, subject to Section 18 below, in writing after the Award Agreement is issued (but in such case only with respect to acceleration of vesting upon (1) a grantee's death, (2) a grantee's Disability, or (3) a Change of Control or Sale Event), a grantee's rights in all Dividend Equivalent Rights or interest equivalents granted as a component of a Deferred Stock Award, Restricted Stock Award or Performance Share Award that has not vested shall automatically terminate upon the grantee's termination of employment (or cessation of service relationship) with the Company and its Subsidiaries for any reason.

SECTION 14.    TRANSFERABILITY OF AWARDS

        (a)    Transferability.    Except as provided in Section 14(b) below, during a grantee's lifetime, his or her Awards shall be exercisable only by the grantee, or by the grantee's legal representative or guardian in the event of the grantee's incapacity. No Awards shall be sold, assigned, transferred or otherwise encumbered or disposed of by a grantee other than by will or by the laws of descent and distribution. No Awards shall be subject, in whole or in part, to attachment, execution, or levy of any kind, and any purported transfer in violation hereof shall be null and void.

        (b)    Administrator Action.    Notwithstanding Section 14(a), the Administrator, in its discretion, may provide either in the Award Agreement regarding a given Award or by subsequent written approval that the grantee (who is an employee or director) may transfer his or her Awards (other than any Incentive Stock Options) to his or her immediate family members, to trusts for the benefit of such family members, or to partnerships in which such family members are the only partners, provided that the transferee agrees in writing with the Company to be bound by all of the terms and conditions of this Plan and the applicable Award.

        (c)    Family Member.    For purposes of Section 14(b), "family member" shall mean a grantee's child, stepchild, grandchild, parent, stepparent, grandparent, spouse, former spouse, sibling, niece, nephew, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including adoptive relationships, any person sharing the grantee's household (other than a tenant of the grantee), a trust in which these persons (or the grantee) have more than 50 percent of the beneficial interest, a foundation in which these persons (or the grantee) control the management of assets, and any other entity in which these persons (or the grantee) own more than 50 percent of the voting interests.

        (d)    Designation of Beneficiary.    Each grantee to whom an Award has been made under the Plan may designate a beneficiary or beneficiaries to exercise any Award or receive any payment under any Award payable on or after the grantee's death. Any such designation shall be on a form provided for that purpose by the Administrator and shall not be effective until received by the Administrator. If no beneficiary has been designated by a deceased grantee, or if the designated beneficiaries have predeceased the grantee, the beneficiary shall be the grantee's estate.

SECTION 15.    TAX WITHHOLDING

        (a)    Payment by Grantee.    Each grantee shall, no later than the date as of which the value of an Award or of any Stock or other amounts received thereunder first becomes includable in the gross income of the grantee for Federal income tax purposes, pay to the Company, or make arrangements satisfactory to the Administrator regarding payment of, any Federal, state, or local taxes of any kind required by law to be withheld by the Company with respect to such income. The Company and its Subsidiaries shall, to the extent permitted by law, have the right to deduct any such taxes from any payment of any kind otherwise due to the grantee. The Company's obligation to deliver evidence of book entry (or stock certificates) to any grantee is subject to and conditioned on tax withholding obligations being satisfied by the grantee.


        (b)    Payment in Stock.    Subject to approval by the Administrator, a grantee may elect to have the Company's minimum required tax withholding obligation satisfied, in whole or in part, by authorizing the Company to withhold from shares of Stock to be issued pursuant to any Award a number of shares with an aggregate Fair Market Value (as of the date the withholding is effected) that would satisfy the withholding amount due.

SECTION 16.    SECTION 409A AWARDS.

        To the extent applicable, it is intended that the Plan and all Awards hereunder comply with the requirements of Section 409A or an exemption thereto, and the Plan and all Award Agreements shall be interpreted and applied by the Administrator in a manner consistent with this intent in order to avoid the imposition of any additional tax under Section 409A. Notwithstanding anything in the Plan or an Award Agreement to the contrary, in the event that any provision of the Plan or an Award Agreement is determined by the Administrator, in its sole discretion, to not comply with the requirements of Section 409A or an exemption thereto, the Administrator shall, in its sole discretion, have the authority to take such actions and to make such interpretations or changes to the Plan or an Award Agreement as the Administrator deems necessary, regardless of whether such actions, interpretations, or changes shall adversely affect a grantee, subject to the limitations, if any, of applicable law. To the extent that any Award is determined to constitute "nonqualified deferred compensation" within the meaning of Section 409A (a "409A Award"), the Award shall be subject to such additional rules and requirements as specified by the Administrator from time to time in order to comply with Section 409A. In this regard, if any amount under a 409A Award is payable upon a "separation from service" (within the meaning of Section 409A) to a grantee who is then considered a "specified employee" (within the meaning of Section 409A), then no such payment shall be made prior to the date that is the earlier of (i) six months and one day after the grantee's separation from service, or (ii) the grantee's death, but only to the extent such delay is necessary to prevent such payment from being subject to interest, penalties and/or additional tax imposed pursuant to Section 409A. Further, the settlement of any such Award may not be accelerated except to the extent permitted by Section 409A. In no event whatsoever shall the Company be liable for any additional tax, interest or penalties that may be imposed on any grantee by Section 409A or any damages for failing to comply with Section 409A.

SECTION 17.    TRANSFER, LEAVE OF ABSENCE, ETC.

        For purposes of the Plan, the following events shall not be deemed a termination of employment:

            (a)   a transfer to the employment of the Company from a Subsidiary or from the Company to a Subsidiary, or from one Subsidiary to another; or

            (b)   an approved leave of absence for military service or sickness, or for any other purpose approved by the Company, if the employee's right to re-employment is guaranteed either by a statute or by contract or under the policy pursuant to which the leave of absence was granted or if the Administrator otherwise so provides in writing.

SECTION 18.    AMENDMENTS AND TERMINATION

        The Board may, at any time, amend or discontinue the Plan and the Administrator may, at any time, amend or cancel any outstanding Award for the purpose of satisfying changes in law or for any other lawful purpose, but no such action shall (a) adversely affect rights under any outstanding Award without the holder's consent or (b) except as provided in Section 3(b) or 3(c), without the prior approval of the Company's stockholders, (1) reduce the exercise price of or otherwise reprice, including through replacement grants, any outstanding Stock Option or Stock Appreciation Right or (2) cancel in exchange for, or otherwise exchange for, cash or other securities any outstanding Stock Option or Stock Appreciation Right with an exercise price at or above the then-current Fair Market Value of the Stock. To the extent required under the rules of any securities exchange or market system on which the Stock


is listed, to the extent determined by the Administrator to be required by the Code to ensure that Incentive Stock Options granted under the Plan are qualified under Section 422 of the Code or to ensure that compensation earned under Awards qualifies as performance-based compensation under Section 162(m) of the Code, Plan amendments shall be subject to approval by the Company stockholders entitled to vote at a meeting of stockholders. Nothing in this Section 18 shall limit the Administrator's authority to take any action permitted pursuant to Section 3(c).

SECTION 19.    STATUS OF PLAN

        With respect to the portion of any Award that has not been exercised and any payments in cash, Stock or other consideration not received by a grantee, a grantee shall have no rights greater than those of a general creditor of the Company unless the Administrator shall otherwise expressly determine in connection with any Award or Awards. In its sole discretion, the Administrator may authorize the creation of trusts or other arrangements to meet the Company's obligations to deliver Stock or make payments with respect to Awards hereunder, provided that the existence of such trusts or other arrangements is consistent with the foregoing sentence.

SECTION 20.    CHANGE OF CONTROL PROVISIONS

        Upon the occurrence of a Change of Control as defined in this Section 20:

            (a)   Unless provision is made in connection with the Change of Control for the assumption or continuation by the successor entity of Awards theretofore granted, or the substitution of such Awards with new Awards of the successor entity or parent thereof, with appropriate adjustment as to the number and kind of shares and, if appropriate, the per share exercise prices, as such parties shall agree, each outstanding Stock Option, Stock Appreciation Right and Dividend Equivalent Right shall automatically become fully exercisable.

            (b)   Unless provision is made in connection with the Change of Control for the assumption or continuation by the successor entity of Awards theretofore granted, or the substitution of such Awards with new Awards of the successor entity or parent thereof, with appropriate adjustment as to the number and kind of shares as such parties shall agree, (i) conditions and restrictions on each outstanding Restricted Stock Award, Deferred Stock Award and Performance Share Award which relate solely to the passage of time and continued employment will be removed. Performance or other conditions (other than conditions and restrictions relating solely to the passage of time and continued employment) will continue to apply unless otherwise provided in the applicable Award Agreement.

            (c)   "Change of Control" shall mean the occurrence of any one of the following events:

                (i)  any "Person," as such term is used in Sections 13(d) and 14(d) of the Act (other than the Company, any of its Subsidiaries, or any trustee, fiduciary or other person or entity holding securities under any employee benefit plan or trust of the Company or any of its Subsidiaries), together with all "affiliates" and "associates" (as such terms are defined in Rule 12b-2 under the Act) of such person, shall become the "beneficial owner" (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, of securities of the Company representing 25 percent or more of the combined voting power of the Company's then outstanding securities having the right to vote in an election of the Company's Board of Directors ("Voting Securities") (in such case other than as a result of an acquisition of securities directly from the Company); or

               (ii)  persons who, as of the Effective Date, constitute the Company's Board of Directors (the "Incumbent Directors") cease for any reason, including, without limitation, as a result of a tender offer, proxy contest, merger or similar transaction, to constitute at least a majority of the Board, provided that any person becoming a director of the Company subsequent to the


      Effective Date shall be considered an Incumbent Director if such person's election was approved by or such person was nominated for election by either (A) a vote of at least a majority of the Incumbent Directors or (B) a vote of at least a majority of the Incumbent Directors who are members of a nominating committee comprised, in the majority, of Incumbent Directors; but provided further, that any such person whose initial assumption of office is in connection with an actual or threatened election contest relating to the election of members of the Board of Directors or other actual or threatened solicitation of proxies or consents by or on behalf of aPerson other than the Board, including by reason of agreement intended to avoid or settle any such actual or threatened contest or solicitation, shall not be considered an Incumbent Director; or

              (iii)  the consummation of (A) any consolidation or merger of the Company where the stockholders of the Company, immediately prior to the consolidation or merger, would not, immediately after the consolidation or merger, beneficially own (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, shares representing in the aggregate more than 50 percent of the voting shares of the corporation issuing cash or securities in the consolidation or merger (or of its ultimate parent corporation, if any), (B) any sale, lease, exchange or other transfer (in one transaction or a series of transactions contemplated or arranged by any party as a single plan) of all or substantially all of the assets of the Company; or

              (iv)  the stockholders of the Company shall approve any plan or proposal for the liquidation or dissolution of the Company.

        Notwithstanding the foregoing, a "Change of Control" shall not be deemed to have occurred for purposes of the foregoing clause (i) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting Securities outstanding, increases the proportionate number of shares of Voting Securities beneficially owned by any person to 25 percent or more of the combined voting power of all then outstanding Voting Securities;provided,however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares of Voting Securities (other than pursuant to a stock split, stock dividend, or similar transaction or as a result of an acquisition of securities directly from the Company), then a"Change of Control" shall be deemed to have occurred for purposes of the foregoing clause (i).

SECTION 21.    GENERAL PROVISIONS

        (a)    No Distribution.    The Administrator may require each person acquiring Stock pursuant to an Award to represent to and agree with the Company in writing that such person is acquiring the shares without a view to distribution thereof.

        (b)    Delivery of Stock.    Notwithstanding any provision of the Plan to the contrary, unless otherwise determined by the Administrator or required by any applicable law, rule or regulation, any obligation set forth in the Plan pertaining to the delivery or issuance of stock certificates evidencing shares of Stock may be satisfied by having issuance and/or ownership of such shares recorded on the books and records of the Company (or, as applicable, its transfer agent or stock plan administrator). Stock certificates to grantees under this Plan shall be deemed delivered for all purposes when the Company or a stock transfer agent of the Company shall have mailed such certificates in the United States mail, addressed to the grantee, at the grantee's last known address on file with the Company. Uncertificated Stock shall be deemed delivered for all purposes when the Company or a Stock transfer agent of the Company shall have given to the grantee by electronic mail (with proof of receipt) or by United States mail, addressed to the grantee, at the grantee's last known address on file with the Company, notice of issuance and recorded the issuance in its records (which may include electronic "book entry" records). Notwithstanding anything herein to the contrary, the Company shall not be required to issue or deliver any shares of Stock pursuant to the exercise of any Award, unless and until


the Administrator has determined, with advice of counsel (to the extent the Administrator deems such advice necessary or advisable), that the issuance and delivery of such shares is in compliance with all applicable laws, regulations of governmental authorities and, if applicable, the requirements of any exchange on which the shares of Stock are listed, quoted or traded. All shares of Stock delivered pursuant to the Plan shall be subject to any stop-transfer orders and other restrictions as the Administrator deems necessary or advisable to comply with federal, state or foreign jurisdiction, securities or other laws, rules and quotation system on which the Stock is listed, quoted or traded. The Administrator may place legends on any Stock certificate to reference restrictions applicable to the Stock. In addition to the terms and conditions provided herein, the Administrator may require that an individual make such reasonable covenants, agreements, and representations as the Administrator, in its discretion, deems necessary or advisable in order to comply with any such laws, regulations, or requirements. The Administrator shall have the right to require any individual to comply with any timing or other restrictions with respect to the settlement or exercise of any Award, including a window-period limitation, as may be imposed in the discretion of the Administrator.

        (c)    Stockholder Rights.    Until Stock is deemed delivered in accordance with Section 21(b), no right to vote or receive dividends or any other rights of a stockholder will exist with respect to shares of Stock to be issued in connection with an Award, notwithstanding the exercise of a Stock Option or any other action by the grantee with respect to an Award.

        (d)    Other Compensation Arrangements; No Employment Rights.    Nothing contained in this Plan shall prevent the Board from adopting other or additional compensation arrangements, including trusts, and such arrangements may be either generally applicable or applicable only in specific cases. The adoption of this Plan and the grant of Awards do not confer upon any employee any right to continued employment with the Company or any Subsidiary.

        (e)    Trading Policy Restrictions.    Option exercises and other Awards under the Plan shall be subject to such Company's insider trading policy and procedures, as in effect from time to time.

        (f)    Forfeiture of Awards under Sarbanes-Oxley Act.    If the Company is required to prepare an accounting restatement due to the material noncompliance of the Company, as a result of misconduct, with any financial reporting requirement under the securities laws, then any grantee who is one of the individuals subject to automatic forfeiture under Section 304 of the Sarbanes-Oxley Act of 2002 shall reimburse the Company for the amount of any Award received by such individual under the Plan during the 12-month period following the first public issuance or filing with the United States Securities and Exchange Commission, as the case may be, of the financial document embodying such financial reporting requirement.

SECTION 22.    EFFECTIVE DATE OF PLAN

        This amended and restated Plan shall become effective upon approval by the holders of a majority of the votes cast at a meeting of stockholders at which a quorum is present. No grants of Stock Options and other Awards may be made hereunder after the tenth anniversary of the Effective Date and no grants of Incentive Stock Options may be made hereunder after the tenth anniversary of the date the amended and restated Plan is approved by the Board.

SECTION 23.    GOVERNING LAW

        This Plan and all Awards and actions taken thereunder shall be governed by, and construed in accordance with, the laws of the State of Delaware.Delaware, applied without regard to conflict of law principles.


ADOPTION AND APPROVAL OF PLAN (AS AMENDED AND RESTATED):

Date Amended and Restated Plan Adopted by Board: April 17, 2015
Date Amended and Restated Plan Adopted by Stockholders/Effective Date: June 10, 2015



Appendix B

IN WITNESS WHEREOFCELLDEX THERAPEUTICS, INC.
2004 EMPLOYEE STOCK PURCHASE PLAN
As amended effective as of July 1, 2015

        1.    Purpose.    The purpose of the Celldex Therapeutics, Inc. 2004 Employee Stock Purchase Plan (the "Plan") is to provide eligible employees of Celldex Therapeutics, Inc. (the "Company") and certain of its subsidiaries with opportunities to purchase shares of the Company's common stock, par value $.01 per share (the "Common Stock"). Two Hundred Thousand (200,000) shares of Common Stock in the aggregate have been approved and reserved for this purpose. The Plan is intended to constitute an "employee stock purchase plan" within the meaning of Section 423(b) of the Internal Revenue Code of 1986, as amended (the "Code"), said corporationand shall be interpreted in accordance with that intent.

        2.    Administration.    The Plan will be administered by the person or persons (the "Administrator") appointed by the Company's Board of Directors (the "Board") for such purpose. The Administrator has caused this certificateauthority to make rules and regulations for the administration of the Plan, and its interpretations and decisions with regard thereto shall be final and conclusive. No member of the Board or individual exercising administrative authority with respect to the Plan shall be liable for any action or determination made in good faith with respect to the Plan or any option granted hereunder.

        3.    Offerings.    The Company will make one or more offerings to eligible employees to purchase Common Stock under the Plan ("Offerings"). Unless otherwise determined by the Administrator, each Offering will begin on the first business day occurring on or after each January 1 and July 1 and will end on the last business day occurring on or before the following June 30 and December 31, respectively. The Administrator may, in its discretion, designate a different period for any Offering, provided that no Offering shall exceed 27 months in duration or overlap any other Offering.

        4.    Eligibility.    Each individual classified as an employee (within the meaning of Section 3401(c) of the Code and the regulations thereunder) by the Company or a Designated Subsidiary (as defined in Section 12) on the Company's or the Designated Subsidiary's payroll records during the relevant participation period are eligible to participate in any one or more of the Offerings under the Plan, provided that as of the first day of the applicable Offering (the "Offering Date") they are customarily employed by the Company or a Designated Subsidiary for more than 20 hours a week and more than five months in the calendar year during which the Offering Date occurs or in the calendar year immediately preceding such year, and have completed at least 30 days of employment.

        5.    Participation.    An employee eligible on any Offering Date may participate in such Offering by submitting an enrollment form to his appropriate payroll location at least 15 business days before the Offering Date (or by such other deadline as shall be established for the Offering). The form will (a) state a whole percentage to be signed this _______deducted from his Compensation (as defined in Section 12) per pay period, (b) authorize the purchase of Common Stock for him in each Offering in accordance with the terms of the Plan and (c) specify the exact name or names in which shares of Common Stock purchased for him are to be issued pursuant to Section 11. An employee who does not enroll in accordance with these procedures will be deemed to have waived his right to participate. Unless an employee files a new enrollment form or withdraws from the Plan, his deductions and purchases will continue at the same percentage of Compensation for future Offerings, provided he remains eligible. Notwithstanding the foregoing, participation in the Plan will neither be permitted nor be denied contrary to the requirements of the Code.

        6.    Employee Contributions.    Each eligible employee may authorize payroll deductions at a minimum of one percent (1%) up to a maximum of fifteen percent (15%) of his Compensation for each pay period. The Company will maintain book accounts showing the amount of payroll deductions


made by each participating employee for each Offering. No interest will accrue or be paid on payroll deductions.

      �� 7.    Deduction Changes.    Except as may be determined by the Administrator in advance of an Offering, an employee may not increase or decrease his payroll deduction during any Offering, but may increase or decrease his payroll deduction with respect to the next Offering (subject to the limitations of Section 6) by filing a new enrollment form at least 15 business days before the next Offering Date (or by such other deadline as shall be established for the Offering). The Administrator may, in advance of any Offering, establish rules permitting an employee to increase, decrease or terminate his payroll deduction during an Offering.

        8.    Withdrawal.    An employee may withdraw from participation in the Plan by delivering a written notice of withdrawal to his appropriate payroll location. The employee's withdrawal will be effective as of the next business day. Following an employee's withdrawal, the Company will promptly refund to him his entire account balance under the Plan (after payment for any Common Stock purchased before the effective date of withdrawal). Partial withdrawals are not permitted. The employee may not begin participation again during the remainder of the Offering, but may enroll in a subsequent Offering in accordance with Section 5.

        9.    Grant of Options.    On each Offering Date, the Company will grant to each eligible employee who is then a participant in the Plan an option ("Option") to purchase on the last day of __________, 2008.such Offering (the "Exercise Date"), at the Option Price hereinafter provided for, (a) a number of shares of Common Stock determined by dividing such employee's accumulated payroll deductions on such Exercise Date by the lower of (i) 85% of the Fair Market Value of the Common Stock on the Offering Date, or (ii) 85% of the Fair Market Value of the Common Stock on the Exercise Date, or (b) such other lesser maximum number of shares as shall have been established by the Administrator in advance of the Offering; provided, however, that such Option shall be subject to the limitations set forth below. Each employee's Option shall be exercisable only to the extent of such employee's accumulated payroll deductions on the Exercise Date. The purchase price for each share purchased under each Option (the "Option Price") will be 85% of the Fair Market Value of the Common Stock on the Offering Date or the Exercise Date, whichever is less.

By: 

Authorized Officer

Title: 
Name: 

(Print or Type)

        Notwithstanding the foregoing, no employee may be granted an option hereunder if such employee, immediately after the option was granted, would be treated as owning stock possessing five percent (5%) or more of the total combined voting power or value of all classes of stock of the Company or any Parent or Subsidiary (as defined in Section 12). For purposes of the preceding sentence, the attribution rules of Section 424(d) of the Code shall apply in determining the stock ownership of an employee, and all stock which the employee has a contractual right to purchase shall be treated as stock owned by the employee. In addition, no employee may be granted an Option which permits his rights to purchase stock under the Plan, and any other employee stock purchase plan of the Company and its Parents and Subsidiaries, to accrue at a rate which exceeds $25,000 of the fair market value of such stock (determined on the option grant date or dates) for each calendar year in which the Option is outstanding at any time. The purpose of the limitation in the preceding sentence is to comply with Section 423(b)(8) of the Code and shall be applied taking Options into account in the order in which they were granted.

        10.    Exercise of Option and Purchase of Shares.    Each employee who continues to be a participant in the Plan on the Exercise Date shall be deemed to have exercised his Option on such date and shall acquire from the Company such number of whole shares of Common Stock reserved for the purpose of the Plan as his accumulated payroll deductions on such date will purchase at the Option Price, subject to any other limitations contained in the Plan. Any amount remaining in an employee's account at the end of an Offering will be refunded to the employee promptly.



        11.    Issuance of Certificates.    Certificates representing shares of Common Stock purchased under the Plan may be issued only in the name of the employee, in the name of the employee and another person of legal age as joint tenants with rights of survivorship, or in the name of a broker authorized by the employee to be his, or their, nominee for such purpose.

        12.    Definitions.

            (a)   The term "Compensation" means the amount of base pay, prior to salary reduction pursuant to either Sections 125, 132(f) or 401(k) of the Code, but excluding overtime, commissions, incentive or bonus awards, allowances and reimbursements for expenses such as relocation allowances or travel expenses, income or gains on the exercise of Company stock options, and similar items.

            (b)   The term "Designated Subsidiary" means any present or future Subsidiary (as defined below) that has been designated by the Board to participate in the Plan. The Board may so designate any Subsidiary, or revoke any such designation, at any time and from time to time, either before or after the Plan is approved by stockholders.

            (c)   The term "Fair Market Value of the Common Stock" as of any date of determination shall be (i) the closing price of a share of Common Stock as of such date on the principal established stock exchange or national market system on which the Common Stock is then traded (or, if there is no trading in the Common Stock as of such date, the closing price of a share of Common Stock on the most recent date preceding such date on which trades of the Common Stock were recorded), or (ii) if the shares of Common Stock are not then traded on an established stock exchange or national market system but are then traded in an over-the-counter market, the average of the closing bid and asked prices for the shares of Common Stock in such over-the-counter market as such date (or, if there are no closing bid and asked prices for the shares of Stock as of such date, the average of the closing bid and the asked prices for the shares of Common Stock on the most recent date preceding such date on which such closing bid and asked prices are available on such over-the-counter market), or (iii) if the shares of Common Stock are not then listed on a national securities exchange or national market system or traded in an over-the-counter market, the price of a share of Common Stock as determined by the Administrator in its discretion in a manner consistent with Section 409A of the Code and Treasury Regulation 1.409A-1(b)(5)(iv), as well as any successor regulation or interpretation.

            (d)   The term "Parent" means a "parent corporation" with respect to the Company, as defined in Section 424(e) of the Code.

            (e)   The term "Subsidiary" means a "subsidiary corporation" with respect to the Company, as defined in Section 424(f) of the Code.

        13.    Rights on Termination of Employment.    If a participating employee's employment terminates for any reason before the Exercise Date for any Offering, no payroll deduction will be taken from any pay due and owing to the employee and the balance in his account will be paid to him or, in the case of his death, to his designated beneficiary as if he had withdrawn from the Plan under Section 8. An employee will be deemed to have terminated employment, for this purpose, if the corporation that employs him, having been a Designated Subsidiary, ceases to be a Subsidiary, or if the employee is transferred to any corporation other than the Company or a Designated Subsidiary. An employee will not be deemed to have terminated employment, for this purpose, if the employee is on an approved leave of absence for military service or sickness, or for any other purpose approved by the Company, if the employee's right to reemployment is guaranteed either by a statute or by contract or under the policy pursuant to which the leave of absence was granted or if the Administrator otherwise provides in writing.


        14.    Special Rules.    Notwithstanding anything herein to the contrary, the Administrator may adopt special rules applicable to the employees of a particular Designated Subsidiary, whenever the Administrator determines that such rules are necessary or appropriate for the implementation of the Plan in a jurisdiction where such Designated Subsidiary has employees; provided that such rules are consistent with the requirements of Section 423(b) of the Code. Such special rules may include (by way of example, but not by way of limitation) the establishment of a method for employees of a given Designated Subsidiary to fund the purchase of shares other than by payroll deduction, if the payroll deduction method is prohibited by local law or is otherwise impracticable. Any special rules established pursuant to this Section 14 shall, to the extent possible, result in the employees subject to such rules having substantially the same rights as other participants in the Plan.

        15.    Optionees Not Stockholders.    Neither the granting of an Option to an employee nor the deductions from his pay shall constitute such employee a holder of the shares of Common Stock covered by an Option under the Plan until such shares have been purchased by and issued to him.

        16.    Rights Not Transferable.    Rights under the Plan are not transferable by a participating employee other than by will or the laws of descent and distribution, and are exercisable during the employee's lifetime only by the employee.

        17.    Application of Funds.    All funds received or held by the Company under the Plan may be combined with other corporate funds and may be used for any corporate purpose.

        18.    Adjustment in Case of Changes Affecting Common Stock.    In the event of a subdivision of outstanding shares of Common Stock, or the payment of a dividend in Common Stock, the number of shares approved for the Plan, and the share limitation set forth in Section 9, shall be increased proportionately, and such other adjustment shall be made as may be deemed equitable by the Administrator. In the event of any other change affecting the Common Stock, such adjustment shall be made as may be deemed equitable by the Administrator to give proper effect to such event.

        19.    Amendment of the Plan.    The Board may at any time, and from time to time, amend the Plan in any respect, except that without the approval, within 12 months of such Board action, by the stockholders, no amendment shall be made increasing the number of shares approved for the Plan or making any other change that would require stockholder approval in order for the Plan, as amended, to qualify as an "employee stock purchase plan" under Section 423(b) of the Code.

        20.    Insufficient Shares.    If the total number of shares of Common Stock that would otherwise be purchased on any Exercise Date plus the number of shares purchased under previous Offerings under the Plan exceeds the maximum number of shares issuable under the Plan, the shares then available shall be apportioned among participants in proportion to the amount of payroll deductions accumulated on behalf of each participant that would otherwise be used to purchase Common Stock on such Exercise Date.

        21.    Termination of the Plan.    The Plan may be terminated at any time by the Board. Upon termination of the Plan, all amounts in the accounts of participating employees shall be promptly refunded.

        22.    Governmental Regulations.    The Company's obligation to sell and deliver Common Stock under the Plan is subject to obtaining all governmental approvals required in connection with the authorization, issuance, or sale of such stock.

        The Plan shall be governed by Massachusetts law except to the extent that such law is preempted by federal law.

        23.    Issuance of Shares.    Shares may be issued upon exercise of an Option from authorized but unissued Common Stock, from shares held in the treasury of the Company, or from any other proper source.


        24.    Tax Withholding.    Participation in the Plan is subject to any minimum required tax withholding on income of the participant in connection with the Plan. Each employee agrees, by entering the Plan, that the Company and its Subsidiaries shall have the right to deduct any such taxes from any payment of any kind otherwise due to the employee, including shares issuable under the Plan.

        25.    Notification Upon Sale of Shares.    Each employee agrees, by entering the Plan, to give the Company prompt notice of any disposition of shares purchased under the Plan where such disposition occurs within two years after the date of grant of the Option pursuant to which such shares were purchased.

        26.    Effective Date and Approval of Shareholders.    The Plan was adopted by the Board of Directors on March 31, 2004 and was effective upon approval by the stockholders of the Company on May 13, 2004.




QuickLinks

ABOUT THE MEETING
PROPOSAL 1: TO ELECT EIGHT DIRECTORS TO SERVE UNTIL THE NEXT ANNUAL MEETING AND UNTIL THEIR SUCCESSORS HAVE BEEN DULY ELECTED AND QUALIFIED
(Proposal No. 1)
Compensation Discussion and Analysis
Summary Compensation Table
Grants of Plan-Based Awards
Outstanding Equity Awards at Fiscal Year-End
Option Exercises and Stock Vested
Employment Agreements
Pension Benefits
Nonqualified Deferred Compensation
Potential Payments Upon Termination of Employment or Change in Control
Director Compensation
Compensation Committee Interlocks and Insider Participation
Risk Considerations
COMPENSATION COMMITTEE REPORT
REPORT OF THE AUDIT COMMITTEE
PROPOSAL 2: RATIFY THE APPOINTMENT OF PRICEWATERHOUSECOOPERS LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 2017 (Proposal No. 2)
PROPOSAL 3: APPROVAL, IN ACCORDANCE WITH THE APPLICABLE RULES OF THE NASDAQ STOCK MARKET, OF THE ISSUANCE OF SHARES OF OUR COMMON STOCK IN CONNECTION WITH MILESTONE PAYMENTS THAT MAY BECOME PAYABLE IN THE FUTURE TO FORMER SECURITYHOLDERS OF KOLLTAN PHARMACEUTICALS, INC. (Proposal No. 3)
PROPOSAL 4: APPROVE THE AMENDMENT TO THE 2008 STOCK OPTION AND INCENTIVE PLAN (Proposal No. 4)
PROPOSAL 5: APPROVAL OF AN AMENDMENT TO THE 2004 EMPLOYEE STOCK PURCHASE PLAN (Proposal No. 5)
PROPOSAL 6: ADVISORY VOTE ON EXECUTIVE COMPENSATION (Proposal No. 6)
PROPOSAL 7: ADVISORY VOTE ON THE FREQUENCY OF STOCKHOLDER ADVISORY VOTES ON EXECUTIVE COMPENSATION (Proposal No. 7)
STOCKHOLDER PROPOSALS
WHERE YOU CAN FIND ADDITIONAL INFORMAITON
OTHER MATTERS
CELLDEX THERAPEUTICS, INC. 2008 STOCK OPTION AND INCENTIVE PLAN as amended and restated effective as of June 10, 2015
ADOPTION AND APPROVAL OF PLAN (AS AMENDED AND RESTATED)
CELLDEX THERAPEUTICS, INC. 2004 EMPLOYEE STOCK PURCHASE PLAN As amended effective as of July 1, 2015